Conserved Protein Domain Family
GT29_ST6GALNAC5
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cd23976: GT29_ST6GALNAC5 
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467704
Aligned: 6 rows
Threshold Bit Score: 513.647
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
Download Cn3D
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             ###                    ##                    #             
Q9BVH7        79 GYLGVADHKPLKMHCRDCALVTSSGHllhsrqGSQIDQTECVIRMNdAPTRGYgrDVGnRTSLRVIAHSSIQRilrnrhd 158 human
XP_005998994 258 GYINIINHKPLRMHCKTCVLVTSSGHltgsnrGNEIDQAECVIRMNdAPTKGYgkDVGnKTSLRVIAHSSMQYilrnrne 337 coelacanth
NP_001006663  56 GYISIIDHKPLKTHCRSCALVTSSGHmtgsgrGAEIDETECVIRMNdAPTRRYqkDVGqHTNLRVIAHSSMQRvlrnrye 135 zebrafish
OCT82542      53 GYISISEHKPLKMHCKICALVTSSGHllgskqGNKVDQTECVIRMNdAPTRGYgqDVGnKTSLRVIAHSSIQRilrnrne 132 African clawed ...
NP_001264423  92 GYISVLEHKPLKMHCKSCALVTSSGHllgskqGDRIDETECVIRMNdAPTRGYgqDVGnKTSLRVIAHSSIQRilrnrne 171 chicken
XP_007885457  74 GYINFIDHKPLKIHCKNCALVTSSGHltgsnrGTEIDETDCVIRMNdAPTRGYrkDVGqKTSLRVIAHSSIQRilqkrne 153 elephant shark

Feature 1                                                                                 ###    
Q9BVH7       159 llnvsqgTVFIFWGPSsymrrdgkgqvynnlhllsqvlPRLKAFMITRHKMLQFDELFKQETGKDRkisntWLSTGWFTM 238 human
XP_005998994 338 llnvshgTVFIFWGPTsymrkdgkglvynnlkgmnqilPQLKLYVITRQKMLQFDELFKRETGKDRkvsntWLSTGWFTM 417 coelacanth
NP_001006663 136 llnssqdTFFIFWGPGnymrrdgkglvynnlrlmkqlmPKLQVYIISRPKMLQFDELFKKETGKDRkrsnsWLSTGWFTM 215 zebrafish
OCT82542     133 llnisqgTVFIFWGPSnymrrdgkgllynnlqlinrilPRLKVHTITRHKMLQFDELFKKETGKDRkisntWLSTGWFTM 212 African clawed ...
NP_001264423 172 llnmshgAVFIFWGPSsymrrdgkglvynnlqlmnqilPQLKAYMISRHKMLQFDDLFKRETGKDRkisntWLSTGWFTM 251 chicken
XP_007885457 154 llnvtqdPVFVFWGPSnymkrdgkglvynhlqlihqilPKLNIYTITRQKMLYFDELFKRETGKDRktsnsWLSTGWFTM 233 elephant shark

Feature 1                     ##               ###                        #                      
Q9BVH7       239 TIALElCDRINVYGMVPPDFCRdpn-hpsVPYHYYEPFGPDECTMYLSHERgrkgshHRFITEKRVFKNWARTFNIHFFQ 317 human
XP_005998994 418 IIAIElCDRIAVYGMAPPNFCRdrr-hrsVPYHYYEPSGPDECRMYISHEWgqkgshHRFITEKKVFAKWAQIFNILFFQ 496 coelacanth
NP_001006663 216 AIAIEmCDRINVYGMVPPEFCKsphtkpsVPYHYYEPSGTDECTMYVTHEQgrhgshHRFITEKRVFAKWARMFNIHFYQ 295 zebrafish
OCT82542     213 SIALElCDRINVYGMVPPDFCRapn-htlVPYHYYEPMGPDECTMYISHERgrkgshHRFITEKRVFANWARTFNIHFYQ 291 African clawed ...
NP_001264423 252 TIALElCDRINVYGMVPPDFCRdpn-hlsVPYHYYEPLGPDECTMYISHERgrkgshHRFITEKRVFENWARTFNIHFFQ 330 chicken
XP_007885457 234 IIALEfCDRINIYGMVPPTFCRnph-hqsVPYHYYEPLGPDECTMYISHERgqkgshHRFITEKRVFAGWAQRYNIHFYQ 312 elephant shark

Feature 1             
Q9BVH7       318 PDWKP 322 human
XP_005998994 497 PDWKP 501 coelacanth
NP_001006663 296 PDWGP 300 zebrafish
OCT82542     292 PDWKP 296 African clawed frog
NP_001264423 331 PDWKP 335 chicken
XP_007885457 313 PDWRP 317 elephant shark

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