Conserved Protein Domain Family
DC_STAMP

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pfam07782: DC_STAMP 
DC-STAMP-like protein
This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.
Statistics
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PSSM-Id: 462265
Aligned: 94 rows
Threshold Bit Score: 103.46
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CUT99402      550 FDNGHITSQFVAQERRAlehgrptalplTHSERMNYVALTACKWSKAERNAAVGSLVFLFVGMITLVLIIFADYAMYQVV 629 
XP_008273010  254 FDNTYATHQLTELLAQAgat------hlLNPPPSWLLQTGRPKLSREELLHCALKLGLPALLLVATAVTVATDHVTFLLA 327 
XP_023406088  254 FDNIYATRQLVGQLAEAqat------hlVASPPAWLLQAAQPRLTQEELLSCLLRLGMLTLLLAATAVTAATDHVAFLLA 327 
NP_001268651  255 FDNIYATRQLTQRLAEVgat------hlTASPPAWLLWAAQPRLSQAELLSCLVRLGLFTLLLMAMAVTVAMDYVAFLLA 328 
XP_015425822  168 FDNVYATRRLAQQLGEAgat------hlLASPPAWLLRAAWPRLSQGELLSCLLRLGLLTLLLVATAVTVATDHVAFLLA 241 
XP_011526834  248 FDNIYATQQLTQRLAQAqat------hlLAPPPTWLLQAAQLRLSQEELLSCLLRLGLLALLLVATAVAVATDHVAFLLA 321 
EHB05322      172 FDNIYMTRRLAQQLAQAqat------hlMDVPPAWLLQVAQPKLSQEELLSCLLRLGLLVLLLVATAVTVATDYMAFLLA 245 
XP_015220051  262 FDNVYITRQLERLARRngi-------eiLPGDAKKLISSRGCRMSQQEFLRCVPYLLVITSYLILTLVVIAVDHMVFHFI 334 
XP_005057217  266 FDNFYITKKLERLATDRraa------hlLVGSSKKLIRPTGLRLSWEEVALCLVRAMLVTVALMLMLVLVAMDHFAFSVA 339  Collared flyc...
XP_016848491  278 FDNIYITKKLEYLAQERkti------hlLSCTSRKLIKPTGLKLTREELMTSLTHIFLLTLVLILTLVIIATDYIAFHLA 351  green anole
CUT99402      630 LTTSPAF---STGFGEVqqtleegisdqisdfgigaseqvVPEIQG-----------------NSTMSEIGRSFMNL--A 687 
XP_008273010  328 QVAVDWAqnlSTVPITL-----------------------SVKYDA-----------------AFSVLDFVPFLFNqppp 367 
XP_023406088  328 QAVVDWAqklPSVPVTL-----------------------LLKYDS-----------------TYTILDFIPFLFDhmpp 367 
NP_001268651  329 QAAVDWArelPAVPVTL-----------------------TIKYNA-----------------AYTILGFLPFLFNRppL 368 
XP_015425822  242 QAAVDWAqklPAVPVTL-----------------------MVKYDA-----------------AYTVLDFVPFLFNqrpl 281 
XP_011526834  322 QATVDWAqklPTVPITL-----------------------TVKYDV-----------------AYTVLGFIPFLFNQ--L 359 
EHB05322      246 QAAVKWAqklPIVPITL-----------------------TVKYDA-----------------AYTVLGFIPFLFNypap 285 
XP_015220051  335 VAGGLWLsgdPYVTATI-----------------------DVKY-------------------------TVRRITPi--C 364 
XP_005057217  340 DTAVRKAaqfSAVPVTL-----------------------NIRYk-----------------vEIGPVPFLFKIFRrpse 379  Collared flyc...
XP_016848491  352 QAAVSEAtqfPVVPISF-----------------------WIKYDVstkatspktnsllffqvKLTFIEFFGKVFNnafs 408  green anole
CUT99402      688 NP-------------LKDIA-FSVDATICRPRP-SEPDHETTILIGLALVLTLLSIIVQVYVLRLRHLILAWYYPDGANR 752 
XP_008273010  368 es-------lwvstdHTFRWeLSLTSRTCRLLPaQRPRVAGALAAGALQLLAGCTVLLDAYARRLRHATAAAFFAAQEAR 440 
XP_023406088  368 es-------pflsahSSYQWeLRLASPDCRLLPaQHPRTPASLAAGALQLTAWATVFLETYALRLRHAIAASFFTAQEAR 440 
NP_001268651  369 ENpyl-------sahNSFQWeLRFTAPGCPLLPaQRPHTAAPLAAGALQLAACSTVLLETYARRLRHSIAASFFRTQEAK 441 
XP_015425822  282 ek-------pfhsahKSFQWeLRFTSPACPLLPaQRPLTAAPLAAGVLQLVACSTVLLETYARRLRHTIAASFFTAQEAR 354 
XP_011526834  360 APespf-----lsvhSSYQWeLRLTSARCPLLPaRRPRAAAPLAAGALQLLAGSTVLLEAYARRLRHAIAASFFTAQEAR 434 
EHB05322      286 es-------sflsmhKAYTWeLRLTSRDCPLLPaQRPCTDSALAAGALQLLAGSTVLLETYARRLRHAIAASFFSSQEAR 358 
XP_015220051  365 SLfhsscdeeilrhqKPYHWsFNLVPGRCVIEP-SKPDSGVVLQLGLLYLMAYILVVFEVYIRRVRRRVSASFFKRQEER 443 
XP_005057217  380 el-------llgdfnKTYHHhLVFSSARCRTSApTAPNRSVLLAVGLLFLLLYSTVLLETLARRLCRQIAASFFPSREQR 452  Collared flyc...
XP_016848491  409 ieq------skspfeRSYYQnLTFLSANCSLRYpKPPNTAVTFAVGLLYCIIYAITFLETYSRRLCRKIAASFFKNQEDQ 482  green anole
CUT99402      753 RAAWLR 758 
XP_008273010  441 RARHLH 446 
XP_023406088  441 RILHLR 446 
NP_001268651  442 RVCHLH 447 
XP_015425822  355 RVHHLH 360 
XP_011526834  435 RVRHLH 440 
EHB05322      359 RVCHLH 364 
XP_015220051  444 RIVFLY 449 
XP_005057217  453 RVLHLY 458  Collared flycatcher
XP_016848491  483 RIQYLY 488  green anole
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