3I76


Conserved Protein Domain Family
YjjG/YfnB
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TIGR02254: YjjG/YfnB 
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noncanonical pyrimidine nucleotidase, YjjG family
This HAD superfamily includes including YjjG from E. coli and YfnB from B. subtilis. YjjG has been shown to act as a house-cleaning enzyme, cleaving nucleotides with non-canonical nucleotide bases. This family is a member of the haloacid dehalogenase (HAD) superfamily of hydrolases which are characterized by three conserved sequence motifs. By virtue of an alpha helical domain in-between the first and second conserved motif, this family is a member of subfamily IA (TIGR01549).
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Statistics
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PSSM-Id: 162788
Aligned: 5 rows
Threshold Bit Score: 324.058
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3I76_A         6 YRTLLFDVDDTILDFQAAEAlaLRLLFE----DQNIPLTNDMKAQYKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYG 81  Bacillus subtilis
WP_000872931   3 YDWILFDADETLFHFDAFKG--MQLMFA----RKGVEFTEQDFHQYQEVNKPLWVDYQNGDITAAQLKHTRFAGWAEKLN 76  Vibrio cholerae
WP_003244307   4 YRTLLFDVDDTILDFQAAEAlaLRLLFE----DQNIPLTNDMKAQYKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYG 79  Bacillales
WP_004080184   2 KKGVLFDLDGTILDFEKSEDqaLKRTFL----KYGIPLTEDQVFLYREINRKWWKLLAEGKVSKDVVVVARFEEFLKTLN 77  Thermotoga mari...
AAQ65467       2 IKHLFIDLDDTLWDTYHNNKssLEELYHthawDRYFDSFETFFSIYLPHNEALWSEYRYGQIDKPTLTLERFRRPFTGYL 81  Porphyromonas g...

3I76_A        82 YEADGa--lLEQKYRRFLEEGHQLIDGAFDLISNLQQQ-FDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKP 158 Bacillus subtilis
WP_000872931  77 TTTDE----LNSAFLQAMADICTLLPGAMELMQALQGK-ARLGIITNGFTELQDVRLAKTGMTDFFDQIVISEEVGIAKP 151 Vibrio cholerae
WP_003244307  80 YEADGa--lLEQKYRRFLEEGHQLIDGAFDLISNLQQQ-FDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKP 156 Bacillales
WP_004080184  78 IPLDPr--kVAKDYLEFLSEEAHFLPGAEEFLERLKKKdLRMAVVTNGVRFVQEKRSRKLKLDRFFEFVLTSEEAGVEKP 155 Thermotoga mari...
AAQ65467      82 TLSDEqilaWNAEFLSITGRKTRLCPHALEVMEYLHRY-YKVYILSNGFREIQHAKLTNSGLAPYIDRVILSEDAGINKP 160 Porphyromonas g...

3I76_A       159 MKEYFNYVFERIpQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPE--IIPTYEIRKLEELYHIL 229 Bacillus subtilis
WP_000872931 152 DAGIFAHALERMgNPTKSRVLMVGDNPHSDILGGLNFGIETCWLNVHQHPKPDG--ITPHYEVTSLHELREIL 222 Vibrio cholerae
WP_003244307 157 MKEYFNYVFERIpQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPE--IIPTYEIRKLEELYHIL 227 Bacillales
WP_004080184 156 DPRIFWLALERM-KLKKEEVLYVGDDFSSDLEGARNAGIDFVLFSSDGDS-SGD--FPVARNFKELEKIVEEF 224 Thermotoga maritima
AAQ65467     161 NKKIFDFALVKA-KARKTESIMIGDSWEADIVGAANAGLASVWYNPNRHILPDDgvRAPMHIISSLSELMQIF 232 Porphyromonas gingival...
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