Conserved Protein Domain Family
Tet_JBP

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pfam12851: Tet_JBP 
Oxygenase domain of the 2OGFeDO superfamily
A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.
Statistics
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PSSM-Id: 372343
Aligned: 13 rows
Threshold Bit Score: 159.469
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001120680 1290 SWSMYYNGCK-------FARSKIPRKFKLLGDDP-------------KEEEKLESHLQNLSTLMAPTYKKLAPDAYN--- 1346
Q4JK59       1203 SWSMYYNGCK-------FARSKKPRKFRLHGAEP-------------KEEERLGSHLQNLATVIAPIYKKLAPDAYN--- 1259 house mouse
EKC18772      541 SWSMYYNGCK-------FARSREARKFKL--KDT-------------TKEVELEGKLQDLATKMAPLYQQMAPDAYS--- 595 
Q8NFU7       1580 SWSMYFNGCK-------FGRSPSPRRFRIDPSSP-------------LHEKNLEDNLQSLATRLAPIYKQYAPVAYQ--- 1636 human
Q3URK3       1528 SWSMYFNGCK-------FGRSENPRKFRLAPNYP-------------LHEKQLEKNLQELATVLAPLYKQMAPVAYQ--- 1584 house mouse
Q0RM59         55 alrravlrircealsrakgalnisRNFGFTPRRPvygregcqigrlaAESPQEHRVLERWALLLERTLDQIDPSIVAr-- 132  Frankia alni ...
P86938        130 gIAGYFDYRG-------TPVELKCRKTSFTYEHT-------------KEWRSVF----PMIDYTSAIYKAALPDHWK--- 182  Trypanosoma b...
Q4DBW3        124 GIAGYFDYRG-------SPVELKCRKTSFTYENV-------------HSWPNVF----PMIDYVSAIYKAVFPEQWA--- 176  Trypanosoma c...
Q4DUV6        209 GIVGYYDYLN-------NPTQRKCRETEFTRKN----------------WSSVVDSCEPFLVALNKLYSECAPTHYK--- 262  Trypanosoma c...
AAZ12529      307 GILGYYDYLN-------NPTKRKCRMTEFTRRN----------------WGKIIGPCGELLQLLDQLYKENAPDHYE--- 360 
XP_001883228   44 SPSWFSQGHE---------GPEDPLRASADIQE--------------PANSTYLQNVLLANAIVGAIYAVIQPDLFEsgl 100 
XP_001831108  194 APAWWAVGHEks----sLPGPSTPLKSK--------------------SGIKFVDEMEESLALVGAILSVVHPELYEigc 249 
EFI27290      199 ELCNLPDGARrpalcpiFLGPDSA------------------------MYIKFLEEMQESFAVLGGILAVTHPWLFDagl 254 
NP_001120680 1347 ---------NQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQNGSTLVCTLTredNREFGGKPEDEQLhv 1417
Q4JK59       1260 ---------NQVEFEHQAPDCCLGLKEGRPFSGVTACLDFSAHSHRDQQNMPNGSTVVVTLNredNREVGAKPEDEQFhv 1330 house mouse
EKC18772      596 ---------NQTQFEDTARMCRLGNEEGRPFSGVTACVDFCAHSHRDLHNMNNGSTVVVTLTk--HRGMG-KPDDEQLht 663 
Q8NFU7       1637 ---------NQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTredNRSLGVIPQDEQLhv 1707 human
Q3URK3       1585 ---------NQVEYEEVAGDCRLGNEEGRPFSGVTCCMDFCAHSHKDIHNMHNGSTVVCTLIradGRDTNC-PEDEQLhv 1654 house mouse
Q0RM59        133 ---------DAQTMTQVDSSWRLG--GGRLWTSGVINRSSALPYHRDRFNF-STWSAMPVLRr--G-IRGGYLALPEW-- 195  Frankia alni ...
P86938        183 --------------AQDAAVPDVVRIHGSPFSTLTVNERFRTASHTDNGDFDNGYGVLAVLK---GEYSGLSLALDDY-- 243  Trypanosoma b...
Q4DBW3        177 --------------AQDAAVPDIVRIHGSPFSTLTVNQQFRTASHTDAGDFDMGYGLLAVLE---GKFEGLSLALDDF-- 237  Trypanosoma c...
Q4DUV6        263 --------------LQRIAIPRHYQLFNTVFSTMTVNRNFRTAVHTDRGDFRSGLAALCVID---GVFEGCHLAIKKL-- 323  Trypanosoma c...
AAZ12529      361 --------------LQRRVIPPEYMLFNTVFSTVSVNKNFRTAVHRDKGDFRGGLTALCVLD---GNYEGCYLALKSA-- 421 
XP_001883228  101 at---feklANHAEALDDPINIALRVWATPFTGLSVILNRETIDHRDLKGYRESFDLLLTI----GNYTGGRCHLAGL-- 171 
XP_001831108  250 hvmnemrvaDESQVKYPEQVHRVLKTWASPFTALSLIINRETIQHRDTSGPRYGMDILVTG----GRYENGRFETPGL-- 323 
EFI27290      255 sil-sslehGKIDISQPENLLDVLSFWSSPFSKFELVTNRETILQRIVTSPTWAYDLVWTG----GTLTLGRFECPTL-- 327 
NP_001120680 1418 lplykvsdvdefgsveaqeekkrsgaiqvlssfrrkvrmlaepvktcrqrkleakkaaaeklsslenssnknekeksaps 1497
Q4JK59       1331 lpmyiiapedefgstegqekkirmgsievlqsfrrrrvirigelpksckkkaepkkaktkkaarkrsslencssrtekgk 1410 house mouse
EKC18772      664 lplhvmdmtdehgcseaqfekarngslevlqyypmearmravpltpkkkkkgkkggngpakkgrpfkktepsqnqkdskf 743 
Q8NFU7       1708 lplyklsdtdefgskegmeakiksgaievlaprrkkrtcftqpvprsgkkraammtevlahkiravekkpiprikrknns 1787 human
Q3URK3       1655 lplyrladtdefgsvegmkakiksgaiqvngptrkrrlrftepvprcgkrakmkqnhnksgshntksfssasstshlvkd 1734 house mouse
Q0RM59            --------------------------------------------------------------------------------      Frankia alni ...
P86938            --------------------------------------------------------------------------------      Trypanosoma b...
Q4DBW3            --------------------------------------------------------------------------------      Trypanosoma c...
Q4DUV6            --------------------------------------------------------------------------------      Trypanosoma c...
AAZ12529          --------------------------------------------------------------------------------     
XP_001883228      --------------------------------------------------------------------------------     
XP_001831108      --------------------------------------------------------------------------------     
EFI27290          --------------------------------------------------------------------------------     
NP_001120680 1498 rtkqtenasqakqlaellrlsgpvmqqsqqpqplqkqppqpqqqqrpqqqqphhpqtesvnsysasgstnpymrrpnpvs 1577
Q4JK59       1411 ssshtklmenashmkqmtaqpqlsgpvirqpptlqrhlqqgqrpqqpqppqpqpqttpqpqpqpqhimpgnsqsvgshcs 1490 house mouse
EKC18772      744 sidenkkfltyedmmklseepgfaqiipmfiehsqgnssfsfyisqeaedarfvlefrtndivvtddnenlaklccvlee 823 
Q8NFU7       1788 tttnnskpsslptlgsntetvqpevksetephfilkssdntktyslmpsaphpvkeaspgfswspktas----------- 1856 human
Q3URK3       1735 estdfcplqassaetstctysktasggfaetssil--------------------------------------------- 1769 house mouse
Q0RM59            --------------------------------------------------------------------------------      Frankia alni ...
P86938            --------------------------------------------------------------------------------      Trypanosoma b...
Q4DBW3            --------------------------------------------------------------------------------      Trypanosoma c...
Q4DUV6            --------------------------------------------------------------------------------      Trypanosoma c...
AAZ12529          --------------------------------------------------------------------------------     
XP_001883228      --------------------------------------------------------------------------------     
XP_001831108      --------------------------------------------------------------------------------     
EFI27290          --------------------------------------------------------------------------------     
NP_001120680 1578 pypnsshtsdiygstspmnfystssqaagsylnssnpmnpypgllnqntqypsyqcngnls------------------- 1638
Q4JK59       1491 gstsvytrqptphspypssahtsdiygdtnhvnfyptsshasgsylnpsnymnpylgllnq------------------- 1551 house mouse
EKC18772      824 ifqkgikskykgngifnrinckeskwfdksdyfwpwvakipsfskercnpilsmvidtvkeskkvtldlgrgrlfirsal 903 
Q8NFU7            --------------------------------------------------------------------------------      human
Q3URK3            --------------------------------------------------------------------------------      house mouse
Q0RM59            --------------------------------------------------------------------------------      Frankia alni ...
P86938            --------------------------------------------------------------------------------      Trypanosoma b...
Q4DBW3            --------------------------------------------------------------------------------      Trypanosoma c...
Q4DUV6            --------------------------------------------------------------------------------      Trypanosoma c...
AAZ12529          --------------------------------------------------------------------------------     
XP_001883228      --------------------------------------------------------------------------------     
XP_001831108      --------------------------------------------------------------------------------     
EFI27290          --------------------------------------------------------------------------------     
NP_001120680 1639 ------------------vdncspylgsyspqsqpmdlyrypsqdplsklslppihtlyqprfgnsqsftskylgygnqn 1700
Q4JK59       1552 -----------------nnqyapfpyngsvpvdngspflgsyspqaqsrdlhrypnqdhltnqnlppihtlhqqtfgdsp 1614 house mouse
EKC18772      904 mkkvltvpvqiiaknrqlatevyyendsilgneilaeilqsllfelteahfqlrvhnasfldktwnlpiykqyelvpcdn 983 
Q8NFU7            --------------------------------------------------------------------------------      human
Q3URK3            --------------------------------------------------------------------------------      house mouse
Q0RM59            --------------------------------------------------------------------------------      Frankia alni ...
P86938            --------------------------------------------------------------------------------      Trypanosoma b...
Q4DBW3            --------------------------------------------------------------------------------      Trypanosoma c...
Q4DUV6            --------------------------------------------------------------------------------      Trypanosoma c...
AAZ12529          --------------------------------------------------------------------------------     
XP_001883228      --------------------------------------------------------------------------------     
XP_001831108      --------------------------------------------------------------------------------     
EFI27290          --------------------------------------------------------------------------------     
NP_001120680 1701 mqgdgfssctirpnvhhvgklppypthemdghfmgatsrlppnlsnpnmdykngehhspshiihnysaapgmfnsslhal 1780
Q4JK59       1615 skylsygnqnmqrdafttnstlkpnvhhlatfspyptpkmdshfmgaasrspyshphtdyktsehhlpshtiysytaaas 1694 house mouse
EKC18772      984 lglhvqyingfllvkavepgsvaeendkihagdvidelygealrgnkmsvvhnilqkykglpvhihvvkgfdsqgnlykp 1063
Q8NFU7       1857 ---------atpaplkndatascgfsersstphctmpsgrlsganaaaadgpgisqlgevaplptlsapvmeplinseps 1927 human
Q3URK3       1770 -------------------------------------------hctmpsgahsganaaagectgtvqpaevaahphqslp 1806 house mouse
Q0RM59            --------------------------------------------------------------------------------      Frankia alni ...
P86938            --------------------------------------------------------------------------------      Trypanosoma b...
Q4DBW3            --------------------------------------------------------------------------------      Trypanosoma c...
Q4DUV6            --------------------------------------------------------------------------------      Trypanosoma c...
AAZ12529          --------------------------------------------------------------------------------     
XP_001883228      --------------------------------------------------------------------------------     
XP_001831108      --------------------------------------------------------------------------------     
EFI27290          --------------------------------------------------------------------------------     
NP_001120680 1781 hlqnkendmlshtanglskmlpalnhdrtacvqgglhklsdangqekqplalvqgvasgaedndevwsdseqsfldpdig 1860
Q4JK59       1695 gsssshafhnkendnianglsrvlpgfnhdrtasaqellysltgssqekqpevsgqdaaavqeieywsdsehnfqdpcig 1774 house mouse
EKC18772     1064 iqhliedadvdittaeeliqvkkdnsndykkpphtilneeeaeeipvhgseggatydahylgyvtlgldgrvvriedsvl 1143
Q8NFU7       1928 tgvtepltphqpnhqpsfltspqdlasspmeedeqhseadeppsdeplsddplspaeeklphideywsdsehifldanig 2007 human
Q3URK3       1807 tadspvhaepltspseqltsnqsnqqlpllsnsqklascqvederhpeadepqhpeddnlpqldefwsdseeiyadpsfg 1886 house mouse
Q0RM59            --------------------------------------------------------------------------------      Frankia alni ...
P86938            --------------------------------------------------------------------------------      Trypanosoma b...
Q4DBW3            --------------------------------------------------------------------------------      Trypanosoma c...
Q4DUV6            --------------------------------------------------------------------------------      Trypanosoma c...
AAZ12529          --------------------------------------------------------------------------------     
XP_001883228      --------------------------------------------------------------------------------     
XP_001831108      --------------------------------------------------------------------------------     
EFI27290          --------------------------------------------------------------------------------     
NP_001120680 1861 GVAVAPTHG-SILIECAKREL-------------HATT--PLKNPNR-----------------NhpTRISLVFYQHK 1905
Q4JK59       1775 GVAIAPTHG-SILIECAKCEV-------------HATT--KVNDPDR-----------------NhpTRISLVLYRHK 1819 house mouse
EKC18772     1144 GVLRNHTQRvAVKMELTEKEVlvidtkeeknlleHSYT--EISACGRrtdqlkyiayiagettcSlaKKFNCYVFEMR 1219
Q8NFU7       2008 GVAIAPAHG-SVLIECARREL-------------HATT--PVEHPNR-----------------NhpTRLSLVFYQHK 2052 human
Q3URK3       1887 GVAIAPIHG-SVLIECARKEL-------------HATT--SLRSPKR-----------------GvpFRVSLVFYQHK 1931 house mouse
Q0RM59        196 GEVIACRDG-WTLFFVGRQHV-------------HGVT--PMRTVQPd----------------G--YRFSVVFYALR 239  Frankia alni AC...
P86938        244 GVCFNMQPT-DVLLF-DTHLF-------------HSNTelEAKEANAt----------------W--NRLSCVFYYRa 288  Trypanosoma bru...
Q4DBW3        238 GVCFRMQPR-DILIF-NTHFF-------------HSNTepELNHPRDd----------------W--SRLTCVCYYRA 282  Trypanosoma cru...
Q4DUV6        324 GKAFRLETG-DVLFF-DTSLE-------------HGNT--EVHNFDYc----------------W--KRVSVVCYLRN 366  Trypanosoma cruzi
AAZ12529      422 RKAFCLQVG-DVLFF-DSSLE-------------HGNT--EVHNREGs----------------W--RRISIVCYLRC 464 
XP_001883228  172 GFSLVYDPW-TVVALAGNVLQ-------------HGVC--PVLG-----------------------DRACLAHFWHK 210 
XP_001831108  324 GLRWAYDPG-TLVALLGKILL-------------HGVA--PVNG-----------------------ERWCLAHFWRE 362 
EFI27290      328 GYRFHNTPG-TVFVGHLKLIE-------------HGIA--LGKS-----------------------EQVQIFASFHE 366 
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