Conserved Protein Domain Family
PTS_IIA
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pfam02255: PTS_IIA 
PTS system, Lactose/Cellobiose specific IIA subunit
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.
Links
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Statistics
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PSSM-Id: 460510
Aligned: 188 rows
Threshold Bit Score: 66.3029
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_022002599          6 QIIVGLISSAGQSKSLAFEALKKV-KTGEYDEARKILEQAKEADLQAHTVQTKLIQAEMSGsgNKPE-VGLLMVHAQDHY 83  Faecalib...
cebbi:LBUCD034_1561  13 gIAMKMLTYSGKAKSILSDLMDHLnSSSHDSDIDAQLNEAHQWLVQAHQQQ-NLVIAEA----ETVG-YSLLFTHAQDTL 86 
jgi:Halha_2126        9 KVAFNITLHGGNAKDLAHDALKAA-KEGNNERAENLLEEAREEFNKGHEVQSQAMKQDDKE--DKVY-TNMLLAHAMDHL 84 
Q8Y519                7 EAVVKLILHGGNTRKEAYKAIDFA-EKYQFDEADKHLQIAQDQFQEGHIWQTKLVSIRDSE--TVAH-PSFLLIHGQDHL 82  Listeria...
Q8RC45                5 QIIYNLVLHGGNARAEAYEALDAA-EKGDFEEAERHLQKADEEFYEGHKYQNMLTQGE-----QSQT-PNFLVIHAQDQL 77  Caldanae...
jgi:Clopa_1145       11 QIVFNLVLHGGNARGKAYDALDAA-ENGDFQLAEKCLDDADEEFYQGHDYQNKLIQGQM----DNET-PNFLVIHAQDQL 84 
jgi:Desaci_2516      11 QIILNLVLHGGNARGKAYEALDAA-EEGNFEQAEKNLEEADQEFYEGHKYQNQLIQGQL----EKDTvPNFLVIHAQDQL 85 
jgi:Amet_4186         5 EVIFQIILHAGNARGEAYDALKAA-KEKDFEKAQKHLEEAEKEAGIAHRAQTEIIQGEING--KKVE-MSLLFVHAQDHL 80 
jgi:Toce_0340         5 NSIFEMIAYGGNARAKAYEAAARA-RKGDFELAEKLLKEADEEMLKAHHVQTRLIHEEVQG--KKHE-VSVLLVHAQDHL 80 
IGS:BMQ_1017          9 NEIFELIAYGGNARSLAYEALEAA-EDYDFNKADELLKQSQEELSHAHKTQTALIQRELNG--KTIE-KSLLLIHAQDHL 84 

WP_022002599         84 MTSQLARDLIEELINVFE 101 Faecalibacillus
cebbi:LBUCD034_1561  87 MNTETIEFVIRKSIAAft 104
jgi:Halha_2126       85 MAAKSEMVLIEELIELHQ 102
Q8Y519               83 MTAQAELQLAKRIIEQYK 100 Listeria monocytogenes
Q8RC45               78 MTALAEKNLIKRMIELYK 95  Caldanaerobacter subterraneus subsp. tengcongensis
jgi:Clopa_1145       85 MTALAEKNLIKREIALYR 102
jgi:Desaci_2516      86 MTALAEKNLIKRQIALYK 103
jgi:Amet_4186        81 MTAIAEKGLIENMMDLYK 98 
jgi:Toce_0340        81 MTAMAERSLIENMIDLFR 98 
IGS:BMQ_1017         85 MTAISEQKLIEHMIKLIK 102
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