Conserved Protein Domain Family
3mg
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TIGR00567: 3mg 
DNA-3-methyladenine glycosylase
This families are based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). All proteins in this family for which the function is known are involved in the base excision repair of alkylation damage to DNA. The exact specificty of the type of alkylation damage repaired by each of these varies somewhat between species. Substrates include 3-methyl adenine, 7-methyl-guanaine, and 3-methyl-guanine. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273145
Aligned: 5 rows
Threshold Bit Score: 240.871
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q04841 106 LGPEFFDQPAVTLARAFLGQVLVRRLADGTELrGRIVETEAYLGPED-----EAAHSRGGRQTPRNRGMFMKPGTLYVYL 180 house mouse
P94378   8 LPITFYQKTALELAPSLLGCLLVKETDEGTAS-GYIVETEAYMGAGD-----RAAHSFNNRRTKRTEIMFAEAGRVYTYV 81  Bacillus subtilis sub...
O51383   1 MDRYFFLQDATTVAKLLLGNLLIRKIDKEEIV-TRIVETEAYMGITD-----SACHSYGGKITNRTSAMYRIGGYSYVYI 74  Borrelia burgdorferi B31
O33190   1 MNAEELAIDPVAAAHRLLGATIA-----GRGVrAMVVEVEAYGGVPDgpwpdAAAHSYRGR-NGRNDVMFGPPGRLYTYR 74  Mycobacterium tubercu...
Q39147  59 MPPEFFQIDALDLAPRLLGKFMRR-----DNVvLRITEVEAYR-PND-----SACHGRFGV-TPRTAPVFGPGGHAYVYL 126 thale cress

Q04841 181 IYG-MYFCLNVSSQGAG-ACVLLRALEPLEGLETMRQLRnslrkstvGRSLkdRELCSGPSKLCQALAIDKSFDQRdLAQ 258 house mouse
P94378  82 MHT-HTLLNVVAAEEDVpQAVLIRAIEPHEGQLLMEERRp-------GRSP--REWTNGPGKLTKALGVTMNDYGR-WIT 150 Bacillus subtilis sub...
O51383  75 IYGmHYMFNVVTADKNNpQAVLIRSVEPIS--PLLGEKS---------------ILTNGPGKLTKFLNIDLTFNKVdLIG 137 Borrelia burgdorferi B31
O33190  75 SHGiHVCANVACGPDGTaAAVLLRAAAIEDGAELATSRR--------GQTVraVALARGPGNLCAALGITMADNGIdLFD 146 Mycobacterium tubercu...
Q39147 127 CYGlHMMLNIVADKEGVgAAVLIRSCSPVSGMETIQERR--------GLKTdkPVLLNGPGKVGQALGLSTEWSHHpLYS 198 thale cress

Q04841 259 DDAVWLEHGPLESSSPAvvvaAARIGIGHAGEWTQ-KPLRFYVQGSPWVS 307 house mouse
P94378 151 EQPLYIESGYTPEAIST----GPRIGIDNSGEARD-YPWRFWVTGNRYVS 195 Bacillus subtilis subsp. subtilis str. 168
O51383 138 NNELFLQRGLNLDFNIVc---SKRININYAQESDInKLWRFYIKDNKFVS 184 Borrelia burgdorferi B31
O33190 147 PSSPVRLRLNDTHRARS----GPRVGVSQAADR----PWRLWLTGRPEVS 188 Mycobacterium tuberculosis
Q39147 199 PGGLELLDGGEDVEKVMv---GPRVGIDYALPEHVnALWRFAVADTPWIS 245 thale cress
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