5XSK,2NLU,1RI0,2B8A,5XSK


Conserved Protein Domain Family
PWWP_HDGF
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cd20148: PWWP_HDGF 
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PWWP domain found in Hepatoma-derived growth factor (HDGF)
HDGF, also called high mobility group protein 1-like 2 (HMG-1L2), is a heparin-binding protein that acts as a transcriptional repressor with mitogenic activity for fibroblasts. It contains a PWWP domain, which is necessary for DNA binding.
Links
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Statistics
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PSSM-Id: 438976
Aligned: 10 rows
Threshold Bit Score: 175.983
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5XSK; Rattus norvegicus HDGF dimer in complex with DNA, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # #                                                    ####         
5XSK_A        30 YKCGDLVFAKMKGYPHWPARIDEMPeaavkstaNKYQVFFFGTHETAFLGPKDLFPYEeskeKFGKPNKRKGFSEGLWEI 109 Norway rat
2NLU_A        10 YKCGDLVFAKMKGYPHWPARIDEMPeaavkstaNKYQVFFFGTHETAFLGPKDLFPYEeskeKFGKPNKRKGFSEGLWEI 89  human
1RI0_A        20 YKCGDLVFAKMKGYPHWPARIDEMPeaavkstaNKYQVFFFGTHETAFLGPKDLFPYEeskeKFGKPNKRKGFSEGLWEI 99  human
2B8A_A        10 YKCGDLVFAKMKGYPHWPARIDEMPeaavkstaNKYQVFFFGTHETAFLGPKDLFPYEeskeKFGKPNKRKGFSEGLWEI 89  Norway rat
5XSK_B        30 YKCGDLVFAKMKGYPHWPARIDEMPeaavkstaNKYQVFFFGTHETAFLGPKDLFPYEeskeKFGKPNKRKGFSEGLWEI 109 Norway rat
P51858        10 YKCGDLVFAKMKGYPHWPARIDEMPeaavkstaNKYQVFFFGTHETAFLGPKDLFPYEeskeKFGKPNKRKGFSEGLWEI 89  human
XP_005991719  12 YKAGDLVFAKMKGYPHWPARIDELPegavksssNKYQVFFFGTHETAFLGPKDLFPYEeckeKFGKPNKRKGFSEGLWEI 91  coelacanth
OCT66510      10 YKCGDLVFAKMKGYPHWPARVDEVPepnakssaNRYQVFFFGTHETAYLGSKDIFPYEetkeKFGKTNKRKGFSEGLWEI 89  African clawed ...
PWA15043      10 YKPGDLVFAKMKGYPHWPARIDELPegavkspsNKYQVFFFGTHETAFLGAKDLFPYEeckeKFGKTNKRKGFAEGLWEI 89  western mosquit...
RLV87519      10 YKCGDLVFAKMKGYPHWPARIDEMPeaavksssNKYQVFFFGTHETAFLGPKDLFPYEeckeKFGKPNKRKGFSEGLWEI 89  Gouldian finch

Feature 1               
5XSK_A       110 ENNPTVK 116 Norway rat
2NLU_A        90 ENNPTVK 96  human
1RI0_A       100 ENNPTVK 106 human
2B8A_A        90 ENNPTVK 96  Norway rat
5XSK_B       110 ENNPTVK 116 Norway rat
P51858        90 ENNPTVK 96  human
XP_005991719  92 ENNPSVK 98  coelacanth
OCT66510      90 ENNPTVK 96  African clawed frog
PWA15043      90 ENNPTVT 96  western mosquitofish
RLV87519      90 ENNPTVK 96  Gouldian finch

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