2XR9,4GTX,1EI6,3SZY,4LQY,2GSN


Conserved Protein Domain Family
Enpp

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cd16018: Enpp 
Click on image for an interactive view with Cn3D
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Statistics
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PSSM-Id: 293742
Aligned: 192 rows
Threshold Bit Score: 140.413
Created: 21-May-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2XR9; Rattus norvegicus Enpp2 binds phosphate and Zn++ at active site, defined by 4A distance.
  • Structure:4LQY_A; human ENPP4 binds AMP and Zn++ at active site, defined by 4A distance.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                     ##                    #           
2XR9_A    128 PPLIIFSVDGFRASYMkkg-skvMPNIEKLRSCGTHApYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSmydpvfdasf 206 Norway rat
ETW11371    2 QKTLVILVVGLAPDLVgr----hTPNLAKLAKDGALR-PLDTVTPAVTCSAQATLVTGLQPSGHGIVANGwyfrdlceil 76  Roseivivax sp. 22I...
AHG93173    2 RPTVVLLVVGLTSDLLgd----dTPNLRAFAARGGLR-PLRTIVPAVTCSVHATFTTGLLPRDHGAVANGwyfrdtaevr 76  Gemmatimonadetes b...
AGP32140    2 HRTVVLNVVGLTGDLLgd----aTPNLQRLAREGAMR-PLETVLPAVTCTVQSTFTTGLLPSGHGCVANGwyfrdiaevn 76  Sorangium cellulos...
AFY54427    2 NKTVVINVVGLTKNLLgk----hTPMLSRWAEGGKVA-TVEPVLPAVTCSVQSTYLTGKMPSEHGIVGNGwyfrddcetk 76  Rivularia sp. PCC ...
AAQ60498    2 QPLLLLNVVGLTSRLIge----fTPRLAEFARQGFVQ-PLRNIVPAVTCSVQASMLTGLTPEQHGIVGNGwlfrelaevw 76  Chromobacterium vi...
NP_508470  22 QNLIVILADGYGATLLnntkpdaTFGIRHLATNGVQVdYVTPSFPTHTWPQWMSLSTGLYTENHGFTADYmwdrktnftf 101 Caenorhabditis ele...
ERG84127   26 QNLIVLLIDGLGSSQLnqs-nfeLLGFRHLRESGAHAeYVKPTYPTQSYPNWMSLFSGLYAENHGFTADYmwdvktgtgf 104 pig roundworm
CDQ00369   68 QNLIVFIIDGYGKALLnq----sDIGFRLLTQNGVYSdFLKPVYPTHNYPNWMSLVTGLYAENHGFGANYmwdrvknrrf 143 Brugia malayi
CEF60239   30 QNLIVLLIDGYGNNLFnktnsklSLGIQSLLENGVQTdYLKPIFPTWSYPTWTSLSTGLYPENHHMSSDFmydeenemlf 109 Strongyloides ratti
Feature 1                                                                                     
2XR9_A    207 hl---rgrekfnhrwwGGQPLWITATKQg--vRAGTFFWsvsi------------------------------------- 244 Norway rat
ETW11371   77 -------lwrqpnnlvAGEKIWDAGKARdpnfTSAKMFWwynmyatadfsatprpkypadgrklpdhyaeppelhdelda 149 Roseivivax sp. 22I...
AHG93173   77 -------lwvqsnhlvSGEKVWDAARRVdpsfTCAQLFWwynmysgadytvtprpmypadgrkipdaytqpmalrdelna 149 Gemmatimonadetes b...
AGP32140   77 -------lwrqanqlvAGEKIWEAARRRdpsfTCAKLFWwynmyssadyavtprpiywadglklpdiytepaslrdelvf 149 Sorangium cellulos...
AFY54427   77 -------fwrqsnklvQSPKIWEMARQLdsdfTCANMFWwynmyssanyavtprpmypadgrkipdiytqpsnfreqlqa 149 Rivularia sp. PCC ...
AAQ60498   77 -------fwrqsnrlvGGERLWEAAKRHdpdfRCANLFWwynmasshdfgatprpiykadgrklpdchtkpaawrdrlta 149 Chromobacterium vi...
NP_508470 102 ergtgpndtedvwwddAKAPLWYTAGKAg---VDVHCYWfahchrafydmvvqvpekrwa-------------------- 158 Caenorhabditis ele...
ERG84127  105 hkgeqpndtahfwwsdRPAPLWYTAGKAr---VDVHCYWiagchvpyvdlivqvplsrky-------------------- 161 pig roundworm
CDQ00369  144 wkg-etnrvgdswwpdGVVPAWYTTGKSn--vDVHCYWMpgcdlpyqdiivqvpqerkyn-------------------- 200 Brugia malayi
CEF60239  110 qrdegendtdyrwfidEPDPIWYTAGKAn---VNVHCYWfstchrahgdqivrvdkkrrh-------------------- 166 Strongyloides ratti
Feature 1                                                          #   #                      
2XR9_A    245 ------------------pherRILTILQWlslpdnerpSVYAFYSe----qPDFSGHKyg--pfGPEMTNPLREIDKTV 300 Norway rat
ETW11371  150 klgtfplfkfwgpladitssdwIAKSTLHVmet---rdpTLTLSYLp----hLDYNLQRlgpdldHPRLQEDLREVDALC 222 Roseivivax sp. 22I...
AHG93173  150 qlgtfplfnywgpradittsrwIADCAKHIhdt---rrpTLSLVYLp----hLDYNLQRlg--pdDPRIGADLRAIDAIC 220 Gemmatimonadetes b...
AGP32140  150 rlgafplfnfwgpnadirstawIARCARHVvdt---rrpTLTLVYLp----hLDYNLQRlg--pdDPAIQGDLRAVDAVC 220 Sorangium cellulos...
AFY54427  150 efgqfplfnfwgptasiastqwIANSSKWVeek---cspNLTLIYLp----hLDYCLQKfg--pnQDKIAKELQEVDAVC 220 Rivularia sp. PCC ...
AAQ60498  150 elgtfplfhfwgpatsiassrwIAEASKLAiad---frpSLLLSYLph--ldYDLQRHGpd--lsHPAVRQSLRDIDAVA 222 Chromobacterium vi...
NP_508470 159 -nlddqhqtdnlrdifpeianrISKYQVYKq-------qMFLIRYAn----iGNAQKEHgp---eSDEVEQEVARFDLYI 223 Caenorhabditis ele...
ERG84127  162 -nasfseqteslpthfpeiverITKYQAYKq--------QLYLIRYg----gVESTLRLfg--sqSHEGRQAISRADLYL 226 pig roundworm
CDQ00369  201 --aslpeqtdalmsyfpeiierITKYQPYRq-------qFFLIRYAgvq-aaLETFGLR------SDELKQALINVDLSL 264 Brugia malayi
CEF60239  167 --nfrnkndtnllseipslmrhIKKFQPYRq--------QLALMRFngvanaLQNYGEN------SHEFNQALSAADVTI 230 Strongyloides ratti
Feature 1                           ##                                                        
2XR9_A    301 GQLMDglkqlrlhrCVNVIFVGDHGMEDVtcdrteflsnyltnvdditlvpgtlgriraksinnskydpktiiaaltckk 380 Norway rat
ETW11371  223 GELIDyar----atDRRIVVVSEYGITPAtdavhinralreagllrvrpeefgreildagasrafamadhqiahvyvqdp 298 Roseivivax sp. 22I...
AHG93173  221 GEMIEwae----rdGARVVVLSEYGITPVtgavhvnralreagliqvrselgrdmldagaseafavadhqiahvyvrrpe 296 Gemmatimonadetes b...
AGP32140  221 GELIDhvr----kdGARVIVLSEYGITRVsgvvhinralreqglvrvrverglekldagaseafavadhqvahvyvrrpe 296 Sorangium cellulos...
AFY54427  221 GDLINfye----qrGASVVVLSEYGITSVsqpihinrllrskgllaireeegrelldagaskafavadhqiahvyvndad 296 Rivularia sp. PCC ...
AAQ60498  223 GDLIAhar----enGYRVMLVSEYGITPVsravhlnrhlreagllqvrheagaeildpsqcrafavadhqiahvylqpgl 298 Chromobacterium vi...
NP_508470 224 NELQQlledrglfsSTNLVVMSDHGYTPLqkeeqffmeqclpdyslvkkvvnshsmimvftnpedegtvhyefsvcevws 303 Caenorhabditis ele...
ERG84127  227 HDLQQkleerglfeSTNLVVISDHGLHPVdseeqfyieecladfskitkivnshsmmmvftspdeldevffelkvcdqwa 306 pig roundworm
CDQ00369  265 LLLQQkldaeklfeSTNLMVISTHGLYTVeqeeqffieecltdyskiqkvvnhhammmiftnpdeanevffelklcdqwa 344 Brugia malayi
CEF60239  231 RKIQEeleaknlfeTTNFIVLSGHGYMPFdeeeqfyldecledfsrvkrvvnslsmmlvyphegeedtvffelkvcdqwa 310 Strongyloides ratti
Feature 1                                                                              #      
2XR9_A    381 pdq---------------hfkpymkqhlpkrlhyannrriedihllvdrrwhvarkpldvykkpsgkcffqGDHGFDnkv 445 Norway rat
ETW11371  299 dlipkvrgi--iegldgvesvwgaedkarngldhprsgelvavakadrwfsyyywlddavapdfartvdihRKPGYDpve 376 Roseivivax sp. 22I...
AHG93173  297 rvpevrall---erldgvetvldeegkrahgldhprsgelvaissadrwftyyfwldddrapdyartvdihRKPGYDpve 373 Gemmatimonadetes b...
AGP32140  297 rvaevkall---ealpgvdvvldeegkraagldhprsgelvavsredrwfsyyywlddekapeyartvdihRKPGYDpve 373 Sorangium cellulos...
AFY54427  297 cipqvknll---ketegidyvldetskpdyhlnhsrsgeliavansnawftyyywlddkrapdfaravdihRKPGYDpve 373 Rivularia sp. PCC ...
AAQ60498  299 garqmaevedvlrsipgvagvwqgrargelglnheragdlvalaeddawfsyyywlddarapdfartvdihRKPGYDpae 378 Chromobacterium vi...
NP_508470 304 pmgdyde------ndtpfvktyrmselpddlhwknsrfmsgvvlitkpgtsvvtkelptvphsgdptidakQASGWEpyh 377 Caenorhabditis ele...
ERG84127  307 pmgdydd------gdnplvsvyrtselpekfhwkrsrfmpgivimtrpgatvltrelpsipvsdehardirQTGGWDndi 380 pig roundworm
CDQ00369  345 pmgdyde------neqplvsvyqttelpdrfhwknfqympeivlitrpgatvltrelpslpphdeqerdilLTGGWDnen 418 Brugia malayi
CEF60239  311 pmgdyeg------deqplvrvyrhnevperyhwkhgkhmapiviitkpgtilltrqipstdvsealgrevkEISGWDnes 384 Strongyloides ratti
Feature 1                                              
2XR9_A    446 nsmQTVFVGYgptf----kyrTKVPPFENIELYNVMCDLLG 482 Norway rat
ETW11371  377 lffDPELRSPkmkaa-wtlakRKAGQRSLLDVISPNATHLV 416 Roseivivax sp. 22II-s10s
AHG93173  374 lfvDPAIRFPtakvagilarrKLLNSRALLDITPLDASLVK 414 Gemmatimonadetes bacterium KBS708
AGP32140  374 lfaDPALRALpasva-wrllkKKLGFRYLMDVIPLDAGLVR 413 Sorangium cellulosum So0157-2
AFY54427  374 lfvNPQIKFPklkvg-lkllkKKLGFRYLMDVIPLDASLVK 413 Rivularia sp. PCC 7116
AAQ60498  379 lfiDPNIRFPklava-srlakRMLGMRSLMDVIGLDAGIVK 418 Chromobacterium violaceum ATCC 12472
NP_508470 378 ddmKGIFVARgpaf----renERFGPIEIVDVYQMLLNILS 414 Caenorhabditis elegans
ERG84127  381 pemRGIFIARgpaf----krnQQSPPINMVDVYQVLLNILG 417 pig roundworm
CDQ00369  419 lnmHGIFFARgpaf----kedYEASDINVVDIYQVMMNIFG 455 Brugia malayi
CEF60239  385 pdmLGIFMARgpaf----ksnYKTGPIDLVDVYPLMLGVLG 421 Strongyloides ratti

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