Conserved Protein Domain Family
LXG

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pfam04740: LXG 
LXG domain of WXG superfamily
This domain is present is the N-terminal region of a group of polymorphic toxin proteins in bacteria. It is predicted to use Type VII secretion pathway to mediate export of bacterial toxins.
Statistics
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PSSM-Id: 428100
Aligned: 37 rows
Threshold Bit Score: 130.061
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5WDR2          4 KSLDAAQTIDMLQAMASETSDQNGQFAGFSSWMISQHLQSGgRLsSGKTATAIANFWSE---AHGPFLNLLRDVMDDFSN 80   Bacillus clau...
O31506          2 KVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDsEF-SGKGASNIKAFYHD----HVGVADQWIDYIDMKIA 76   Bacillus subt...
O31998          2 KVFEADSLLSEADKRTKEYKELRSQMVKLKKAFKAVADLDDsKF-SGKGADNIKAFYHD----HVGVTDQWIDLIDMKIV 76   Bacillus subt...
Q65NL2          2 KVYEAETLISAMKQRSDEYKNLREQLVSLKKALNSVAELD--EF-QGKGADAIKAFYRD----LSGVVDGWLDLTDMQIQ 74   Bacillus lich...
WP_012010063    2 KILDAPSLLSAIEQRSKVYQELRDEMQHVKKALKSVSGLGD-EF-TGKGADNIKAFYED----LALYTDTYLDFIDMQKA 75   Bacillus pumilus
Q8ERI3          4 K-VDISEVIELSEDVNSSTADIKTSLNSISESIDRLNSLE--SF-SGKTATNAKNYFND---LHKTILVTFEHLFTDLDD 76   Oceanobacillu...
CCZ26007        5 ykimyssMDQFYDQTNGRMAEWVSQLEPWVKACENLGNME--CY-QGKSAESVKTYLKE---VHMTLLTSIQQAIQLYRT 78  
EIM56723       11 A--------AQCESMIEAFRSEKDKLDGVNRSVDN--FSQDsAL-QGKAWSALKQQMSDyalLSEGLLEANRSMIAD-CQ 78  
CCO09564        3 K-MDIGEYKHLLSQMKELKLTLGLSFTGTNGTIEE--FSGDtKL-KGVAWSSTKSYFSA---GYTPMLDGLSDVFYTAIT 75  
Q8YAN8          2 SRIDIGEIQAFLYQLRATNEPGRKTIQSIKAAVTK--YVGDnSL-KGKAVDASKNYYQM---TYFPLCDAIIEAMDESEE 75   Listeria mono...
Q5WDR2         81 KLEQIQNAISD--AFTSEAVLKESFMMDQLYDELDQLKNVVRNFGDALAD-IKNEYSDVLAMPSFDDSKIEQGLTKSQEK 157  Bacillus clau...
O31506         77 FFNSIAGAAEDk-GLS-DAYIEESFLEHELANANKKSKSIMSEQKKAMKD-ILNDIDDILPLDLFSTETFKDELADANDK 153  Bacillus subt...
O31998         77 FLSSISAKLEDa-KMS-DAYIEESFLEHELVNAYTKSKSIMSEQKKAMKD-ILNDINDILPLEIFSTEDFKDKLSSADDK 153  Bacillus subt...
Q65NL2         75 FLNGVSSAAENa-GLSEDTFVDVQFLEQELANVHIHSQNMVSAQQQELSN-ILGQIDDLISLQPFSSDEIKQQLDAANQN 152  Bacillus lich...
WP_012010063   76 FLDGVKGKLDDe-SLGGSTFIDEHFLDAQLKQGIQNNKDMVKEQKEALST-IFDDISDLIELNVFSSKEVNEHLDDANKK 153  Bacillus pumilus
Q8ERI3         77 SLKKHLEMFQSrvDTSESAIIVSDYVK-DLELDIKEDWEKLSLEQDKVRE-TMNSVSDI-------TSAIHPNYYPPEAD 147  Oceanobacillu...
CCZ26007       79 KYLFYREGYYDi-EGDLYAVIPQKTLL-SVKDRMKTEIEDVSDSSLIVQT-SLLNVSDLIALQAPNSYYLKDSMEEVKQN 155 
EIM56723       79 SLSDAVASIED--DPQDEDKLESSIHKLNAANRILQFCKSIAEGAQGIGGgVSPTTSQAVWNTIETYQSMIEDNNRSIEK 156 
CCO09564       76 TLENFIRAFESe-VTASGVKLDLDHLQ-DLQRRRDELQREKTNWLHQIAE----QASKIPGLGHLFDDY---SVLQAEKK 146 
Q8YAN8         76 RLGQYIQDFHAevDSSPDAKIDADGLY-ELGKMIDRIESKKEALAQRMNS---GTEGQM--------QNYRSQLAIAYKQ 143  Listeria mono...
Q5WDR2        158 LQETTAYLYEMDAKMKTPMEYIAEDITLMHTYVDRIRSMISNGSVSIEN 206  Bacillus clausii KSM-K16
O31506        154 RKKTLEKLDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPI 202  Bacillus subtilis subsp. subtilis str. 168
O31998        154 REKTIDKINKLDEDLKTEYAETEQNEQFIQQDFKKLQESTGKGKNATPI 202  Bacillus subtilis subsp. subtilis str. 168
Q65NL2        153 RKDTIKAVEDLDGLLKREYSASEHIQQMIQTDYSALIDATGKGKNASPL 201  Bacillus licheniformis DSM 13 = ATCC 14580
WP_012010063  154 RKDAIEALHKIDHELKTEYAKSEAIEKHLATFYAKMMAATGKGKNAQPM 202  Bacillus pumilus
Q8ERI3        148 KDDVIKIITNLEQELNSFTSVGQEEISSIEDLLNQVATTIENAGTVEGK 196  Oceanobacillus iheyensis
CCZ26007      156 VTDFNQNIIDYEAQHKSEANGELADL--LQSLFATLTEYYTNGTNVTSY 202 
EIM56723      157 MQEKIRQLQTAETQTNYLFLDADMIFKVVNWGYQSVRGAWSNGSyhpde 205 
CCO09564      147 VQ-LMEDFRDFIHRHDSDFSELNGLIEQVLLGLEELGKQRSFNGDKQGY 194 
Q8YAN8        144 -ENILEKYLSFEQSHANFFDHLIDLVQAVQQTIRELQSNIQFNSQTGTY 191  Listeria monocytogenes
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