Conserved Protein Domain Family
FolD

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COG0190: FolD 
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
Statistics
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PSSM-Id: 439960
Aligned: 952 rows
Threshold Bit Score: 254.167
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_110172522   1 MIARTLDGAALARQIREQLQPQVQAFTTQaGRPPGLALVLVGDDPASHVYVGSKKTQGTDVGFRVDLHQRPATTSLDEVL 80 
WP_015050716  21 MTAVRIAGKEMAAQVREQLSREVEELKSK-GVTPSMALILVGDAEDSALYVRSKAKACEGVGAFAETHHLGADTTLEQLL 99 
WP_015311542   1 M---IIDGKVIAKRIRENIKAEIQE---N-NYKPKLAILIAGNDSASKIYANAKVKACAGVGIDAEVFCF-SDSEEGKFL 72 
WP_014453083   1 M---ILDGKEIALRLQNEIKTNVEELKKR-LINPALAVIQVGEEKASESYAKNIRREGENLGIYVEHHKLASDISEEELL 76 
WP_014966451   1 --MATIDCKAIAAKLRENVKADIAAATQKhGEKPFLEIVQVGAHPSSVSYVKSIIRTCDNMEVNHNFAQYDENITEAELI 78 
WP_013258148   1 MAAELIKGLPIAKEIRVEIAKDVEALKAK-GVEPTLAVLLVGDDEASVVYAQSKVKVGDGLGVKVDLKVMAADASQEAVL 79 
WP_014486513   1 -MSDILDGRELAKEIKERIRKETELF----EKKPRIDFLYFEDDKSTEVYFTRAKKQAESVGMIGSLHNLPVTTTEKDFL 75 
WP_041587154   1 M---IIDGKEISNRIKEEVKREIQEF----GYKPRLAILMAGDDESSKVYANSKVKACESVGIEAKVYYF-SEKEEDKFF 72 
WP_013120568   1 MPAQILDGKKLSNEIKEGLKAEVEALKAK-GVVPTIGMLLVGDDEASALYVGLKAKAATAIGGEGKTFKLPEDVTFEEIM 79 
WP_013669800   1 --MQALQAKTITEPLKADLSQRVQALKAQ-GIQPRMVTFLVESDEASAAYAKVKGRLAEKLGVIYDFISLAERTTTQTLV 77 
WP_110172522  81 ALVRGLNADPAIDGILVQSPLPAAMG--SdaaRRVFETIDPAKDVDGFTAENVGRLVQNRE--GLVACTPAGIIELLEQD 156
WP_015050716 100 DLIDRLNKDDKVHGILVQLPLPEHLHeyE---KRVMDAILPEKDIDAFHPVNIGNMVIGDD--CYLGVTANACVKILENI 174
WP_015311542  73 KKLEELNVDENIHGIIVEMPLPKSFN--A---QRTYDLINPLKDVDCISTYNMGRLFAGNP--LYLPCTPHAILTILKQL 145
WP_014453083  77 YNIKNLNLRKDIHGILIELPLPQQIN--K---TKVIETISPEKDVDGFHPINFGKLFEGTT--PFQPATAQAILTAIKSv 149
WP_014966451  79 KEIERLNNDPKVHGVIIQYPLPRHID--Q---DKIANTLSPDKDVDGITSVNLGKLLMGIE--GMVPCTPKGMVRILKES 151
WP_013258148  80 GQIKAWNADPKVHGILVELPLPKHLG--K---EAIMEAIDPKKDVDGVHPVNRGYLLGGQEhlALVPATPLSCVALMERA 154
WP_014486513  76 TLIEYLNKEKETSGIMIQMPLPKHIC--K---KKVYETISIEKDADAISHVNLGRIFIGDS--NLAPCTAKSAMALIEKS 148
WP_041587154  73 DTLEKLNEDKDTHGIMIEMPLPKGFD--V---DKVYDTINPYKDVDCISNYNMGRLFAGKP--LFVPCTPKAIIHILENT 145
WP_013120568  80 ELIDKLNNDPSIHGILVQLPLPKHLHdkE---KAILDAIIPEKDVDGFHPTSIGNLVIGDD--GFVGCTAFACMKLLELT 154
WP_013669800  78 QAIKEKNADSNVHGIMVEMPLPKHID--E---QAVIEAIAPEKDLDGLHPLNLGYLLKGTP--KMIPNTALSALRLIEAS 150
WP_110172522 157 GVTIAGKRAVVIGRSDIVGKPMSLLLLHRHATVTIAHSKTPDLPAVAREADILVAAIGRAGFVTPAFVKPGATVVDVGMN 236
WP_015050716 175 GVDFKGKHAVVVGWSIEIGKPVTMMLFEKGCAVTLVHPD-EDFVPYTKQADIIITEVGRPRAITGEMIKPGAIVIDTGAN 253
WP_015311542 146 DINFTGKHAVIVGRSNILGKPVAKLMLDLDMTVTQCHSKTVDLQKYTKMADVLILAAGKKNLINGDMIKEGAILIDAGIN 225
WP_014453083 150 -VSIEGKHAVVIGRSNIVGKPTAALLLQENATVTICHSKTRNLKDITNLADILVVSVGKPKLIDRNYVKPGAVVIDAGIN 228
WP_014966451 152 GVELQGKDVTLVGNGRTVGKPISQLLLHEGATVTVCHQFTKDLKKHLQQADIVIGAAGVAGLIPGDAVKEGVVVIDAAIN 231
WP_013258148 155 GIDLTGKRVTLVGRGDTVGRPLASLLIKRNATITVCHTRTKDLAAECQRGEIVVAAAGFAGLVKKDMISPGATVIDAGIN 234
WP_014486513 149 GINIEGANAVVIGRSEIVGKPLAHLLLQKSATVTIAHSKTKNLKELCKNADILCVSIGKAEFITGEYIKEGAVVIDIGIN 228
WP_041587154 146 GVDLEGKHAVVIGRSNILGKPVAKLLLDKNCTVTVCHSKTKDLAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAGIN 225
WP_013120568 155 GQDLKGKHAVVVGHSIEVGKPVSMLLFAKGCVVTIVHPDDPKLTEYTKQGDILILEMAKPKFVTGDMVKPGAIVIDTGSN 234
WP_013669800 151 GVKIASKQAVVIGRSNIVGKPLSQLLLSRHATVTVCHSHTQDLTAITQAADILCVAIGKSHFIQADMVKEGAVVIDIGTN 230
WP_110172522 237 RVSEeadvvgffgegskrhlawqqrGsV-LMGDVH-PAVADVAGALTPVPGGVGPLTIAMLMKNTLTA---ASRRV 307
WP_015050716 254 WV-E---------------------G-K-SVGDVDyDSAAEVASYITPVPGGVGPMRIIMLIYNLVEA---AKRKA 302
WP_015311542 226 EY-D---------------------G-K-VYGDCDfQSAENRCLYITPVPGGVGPVTTSMVLLNTLEA---YKNAI 274
WP_014453083 229 KI-D---------------------G-K-LVGDVDfDSVKAIASYITPVPGGIGVLTTLMLFRNTVKA---ANLQS 277
WP_014966451 232 VLED---------------------G-K-IVGDADfEEVSKKASLITPVPGGVGTTTNAMLMENLLGLflgHKEK- 283
WP_013258148 235 ATPD---------------------G-KgICGDAA-PDVEEVAAKMTPVPGGVGSLTTTIIMQNTIKA---IGLQG 284
WP_014486513 229 VLED---------------------G-S-LKGDVNfEEASKLASYITPVPNGVGSVTVSMLLDNVLYL---HKNIM 278
WP_041587154 226 VH-E---------------------G-K-IYGDADfESIKDKASYVTPVPGGVGPVTTAMILKNTLEA---FKYAV 274
WP_013120568 235 WV-D---------------------G-K-QVGDADkESVEQVAGWLSPSPGGVGPMIIAMLMYNLVKA---AQQQS 283
WP_013669800 231 YDEN---------------------G-K-VSGDVDfEALESKEGFLTPVPGGVGPLTTTLIFDQLIRA---IEMSV 280
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