1BZC,1EEO,1EEN


Conserved Protein Domain Family
PTPc-N1
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cd14608: PTPc-N1 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 1
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1), also called protein-tyrosine phosphatase 1B (PTP-1B), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN1/PTP-1B is the first PTP to be purified and characterized and is the prototypical intracellular PTP found in a wide variety of human tissues. It contains an N-terminal catalytic PTP domain, followed by two tandem proline-rich motifs that mediate interaction with SH3-domain-containing proteins, and a small hydrophobic stretch that localizes the enzyme to the endoplasmic reticulum (ER). It dephosphorylates and regulates the activity of a number of receptor tyrosine kinases, including the insulin receptor, the EGF receptor, and the PDGF receptor.
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Statistics
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PSSM-Id: 350456
Aligned: 7 rows
Threshold Bit Score: 625.512
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 13 residue positions
Conserved feature residue pattern:x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Structure:1EEO: Human PTPN1/PTP-1B binds Ac-ELEFpYMDYE-NH(2) consensus peptide; contacts at 4A
  • Structure:1EEN: Human PTP-1B binds Ac-DAD(Bpa)pYLIPQQG Bpa peptide; contacts at 4A
  • Structure:1BZC: Human PTP-1B binds peptide mimetic; contacts at 4A
  • Citation:PMID 9922143
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ####                                              
1BZC_A        16 WAAIYQDIRHEASDFPCRvaklpknKNRNRYRDVSPFDHSRIKLhqednDYINASLIKMeeaqrSYILTQGPlpntcgHF 95  human
AAA91186       3 WAAIYQDIRHEASDFPCKvakhprnKNRNRYRDVSPFDHSRIKLnqrcnDYINASLIKMeeaqrSYILTQGPlpntcgHF 82  chicken
NP_001086085  18 WGSIYQEIRNQASDFPCKvarlqenKARNRYRDVSPFDHSRIKLhrednDYINASLIKVeeaqrSYILTQGPlpntcgHF 97  African clawed ...
AAH49294      42 WNDVYQEIRQQSSDLPCKiaklpenRSRNRYRDVSPFDHSRICLqigcnDYINASLISVeeaqrKYILTQGPlpntcgHF 121 zebrafish
1EEO_A        16 WAAIYQDIRHEASDFPCRvaklpknKNRNRYRDVSPFDHSRIKLhqednDYINASLIKMeeaqrSYILTQGPlpntcgHF 95  human
P18031        16 WAAIYQDIRHEASDFPCRvaklpknKNRNRYRDVSPFDHSRIKLhqednDYINASLIKMeeaqrSYILTQGPlpntcgHF 95  human
1EEN_A        16 WAAIYQDIRHEASDFPCRvaklpknKNRNRYRDVSPFDHSRIKLhqednDYINASLIKMeeaqrSYILTQGPlpntcgHF 95  human

Feature 1                                                                                        
1BZC_A        96 WEMVWEQksRGVVMLNRVmekgsLKCAQYWPqkeekemifedtnLKLTLISEDIKsyYTVRQLELEnlttqetREILHFH 175 human
AAA91186      83 WEMVWEQksRGVVMLNRVmekgsIKCAQYWPrkeekemffedtnLKLTLISEDIKsyYTVRQLELEnlttqetREILHFH 162 chicken
NP_001086085  98 WEMVWEQksIGVVMLNRViekgsIKCAQYWPkkednpmvfddsdLKLTLLSEDIKsyYTIRQLMLEnlstqetREILHFH 177 African clawed ...
AAH49294     122 WEMVWEQrsRGVVMLNRViekgsVKCAQYWPqreereavfedtnFRLTLISEDVKsyYTVRQLELEnlstqetREILHFH 201 zebrafish
1EEO_A        96 WEMVWEQksRGVVMLNRVmekgsLKCAQYWPqkeekemifedtnLKLTLISEDIKsyYTVRQLELEnlttqetREILHFH 175 human
P18031        96 WEMVWEQksRGVVMLNRVmekgsLKCAQYWPqkeekemifedtnLKLTLISEDIKsyYTVRQLELEnlttqetREILHFH 175 human
1EEN_A        96 WEMVWEQksRGVVMLNRVmekgsLKCAQYWPqkeekemifedtnLKLTLISEDIKsyYTVRQLELEnlttqetREILHFH 175 human

Feature 1              #                                #######                                  
1BZC_A       176 YTTWPDFGVPesPASFLNFLFKVRESgslspehgPVVVHCSAGIGRSGTFCLADTCLLLMdkrkdPSSVDIKKVLLDMRK 255 human
AAA91186     163 YTTWPDFGVPesPASFLNFLFKVRESgslnpeygPVVVHCSAGIGRSGTFCLVDTCLLLMdkrkdPSSVDVKQVLLEMRK 242 chicken
NP_001086085 178 YTTWPDFGVPesPASFLNFLFKVRESgslnpehgPIVVHCSAGIGRSGTFSLADTCLLLMdkrkdPSSVEIKQVLLEMRK 257 African clawed ...
AAH49294     202 YTTWPDFGVPesPASFLNFLFKVRESgclspelgPVVVHCSAGIGRSGTFCLVDTCLLLMsqrkdPSSVRIQEVLLEMRR 281 zebrafish
1EEO_A       176 YTTWPDFGVPesPASFLNFLFKVRESgslspehgPVVVHSSAGIGRSGTFCLADTCLLLMdkrkdPSSVDIKKVLLEMRK 255 human
P18031       176 YTTWPDFGVPesPASFLNFLFKVRESgslspehgPVVVHCSAGIGRSGTFCLADTCLLLMdkrkdPSSVDIKKVLLEMRK 255 human
1EEN_A       176 YTTWPDFGVPesPASFLNFLFKVRESgslspehgPVVVHSSAGIGRSGTFCLADTCLLLMdkrkdPSSVDIKKVLLEMRK 255 human

Feature 1              #                              
1BZC_A       256 FRMGLIQTAEQLRFSYLAVIEgakfIMGDSSVQDQWK 292 human
AAA91186     243 YRMGLIQTADQLRFSYLAVIEgakfIMGDASVQEQWK 279 chicken
NP_001086085 258 YRMGLIQTADQLRFSYLAVIEgakfIMGDSSVQEQWK 294 African clawed frog
AAH49294     282 YRMGLIQTADQLRFSYLAFIEgakyIMGDTSVQESWK 318 zebrafish
1EEO_A       256 FRMGLIQTADQLRFSYLAVIEgakfIMGDSSVQDQWK 292 human
P18031       256 FRMGLIQTADQLRFSYLAVIEgakfIMGDSSVQDQWK 292 human
1EEN_A       256 FRMGLIQTADQLRFSYLAVIEgakfIMGDSSVQDQWK 292 human

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