Conserved Protein Domain Family
Fer4_12

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pfam13353: Fer4_12 
4Fe-4S single cluster domain
This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.
Statistics
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PSSM-Id: 433138
Aligned: 64 rows
Threshold Bit Score: 93.3898
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_007070105  12 ANGPG---IRF-----SLF--VSGCTHHCRGCFNPDTW-----------------SFH--------------------YG 44  Dialister invisus
WP_012108211  11 IQGEGkfaGRL-----AVFfrFAGCNLNCAG-FNCELK-----------------SPKtgeilrgcdtiravktahfdYE 67  Campylobacter h...
O25588        12 LQGEG---KRIgkpslFLR--LGGCNLSCKG-FNCKTLlndeiltgcdslyavhpKFK--------------------TS 65  Helicobacter py...
AHJ29476      31 VNGPG---SRA-----VVW--VQGCPRECSGCFNPESW-----------------SFG--------------------IN 63 
WP_013189852  31 VNGPG---CRA-----VVW--VQGCPRECAGCFNPDSW-----------------TFE--------------------IN 63  Trichormus azollae
WP_015795514  22 ALGPG---LRL-----GVW--GQGCPLACSGCMPRGTR-----------------DPD--------------------GG 54  Catenulispora a...
Q0RU46        23 ALGPG---VRS-----AVW--VQGCPFDCAGCVAPDWI-----------------PDR--------------------PA 55  Frankia alni AC...
Q10WY3        15 TLGPG---QRF-----AIW--VQGCCFNCKGCVSPEWI-----------------PQT--------------------QA 47  Trichodesmium e...
WP_006617975  15 tlGPG---NRF-----VIW--VQGCSFNCPGCISPEWI-----------------PQT--------------------QA 47  Arthrospira
WP_011987916  14 VEGPG---TRC-----CIW--VQGCPIHCKGCGAKETW-----------------DFK--------------------GG 46  Clostridium bot...
WP_007070105  45 KPF---T-KETEDYIIRQLGQDCYQGMTLLGGEPMEpvNQ--KGLLPLVKRFKETY---Pe-KDLWCFSGYLFDKEILGh 114 Dialister invisus
WP_012108211  68 KIS---TvSQLLDKIGTNF-KNSLPIIVITGGEPLL--NYanPLFYEFIDEILKRN---Fe--VHFETNGTIFVDFQKF- 135 Campylobacter h...
O25588        66 WDYyneP-KPLIERLEDLAPNYKDFDFILTGGEPSLyfNN--PILISVLEHFYRQK---I--PLCVESNGSIFFEFS--- 134 Helicobacter py...
AHJ29476      64 QLI---S-VDTLAQNI--LSKPNNTGVTFSGGEPFW--QA--TALASLARKLKAAG---L---NIMSFTGFTLKQLQSAs 127
WP_013189852  64 QLV---AiDSLGADILK---NPHNTGVTFSGGEPFW--QA--SALANLARKVKVAG---L---NVMAFTGFTLKQLQSEs 127 Trichormus azollae
WP_015795514  55 VEV---G-AADLERRWRDTMDRGATGLTVSGGELLA--QA--GAFRRFLKSVRRVGsefGgdLDVLISTGYKLGEIDA-- 124 Catenulispora a...
Q0RU46        56 RAV---T-PEVLAE--ELCADPAVEGLTFSGGEPMA--QA--AGLAELIRLARLRR---Pe-LSLVCFTGYRLQRLRAAa 121 Frankia alni AC...
Q10WY3        48 TLI---EpKKLAEMIL---SVPGTEGVTVSGGEPML--QA--IALRELFIYLRQGRq-----ISIICFTGFSLQQLQSQs 112 Trichodesmium e...
WP_006617975  48 TLI---D-HEQLGNLI--LSQPNLDGITVSGGEPML--QA--IALTKLFQHLRNHR---D--ISIICYTGFTLNEIRTKa 112 Arthrospira
WP_011987916  47 ELL---D-TNEVFDIIKN--SKEIEGVTFLGGEPFV--QA--SAVYDIALRAKSIG---L---TVLTFTGYTYDHILKSn 110 Clostridium bot...
WP_007070105 115 fakimpETMELLKYIDILVDGEFVLAKKDIT-LLFKGSSNQRTI 157 Dialister invisus
WP_012108211 136 ---------PLYKNCVFAVSVKLGNSKEPRE-KRLNFTALQNLK 169 Campylobacter hominis
O25588       135 ---------PILKELHFTLSVKLSFSLEEES-KRIHLKALQNIL 168 Helicobacter pylori
AHJ29476     128 a---ppDSAALLAELDILIDGPFVDSLAINSpTSLVSSSNQGVN 168
WP_013189852 128 a---ppGSEELLEQLDILIDGPFVESQAINSpLSPVSSRNQQVH 168 Trichormus azollae
WP_015795514 125 ------DRVEAVDLADAVIMGCYDAASPTDP--LWRGSANQSLL 160 Catenulispora acidiphila
Q0RU46       122 p---spGVTDLLAAVDVLIDGRYVAALNDD--RGLRGSSNQRIH 160 Frankia alni ACN14a
Q10WY3       113 d----qAIDDILTLVDVLIDGQYIEQLNDN--KGWRGSSNQVVH 150 Trichodesmium erythraeum IMS101
WP_006617975 113 ------DIIPLLELIDVIIDGQYIADLND-N-QGWRGSSNQNIH 148 Arthrospira
WP_011987916 111 k----kEWNDLLSVTDLLIDGPFDEDKFDIS-RPWVGSSNQNYR 149 Clostridium botulinum
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