Conserved Protein Domain Family
Glyco_transf_49

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pfam13896: Glyco_transf_49 
Glycosyl-transferase for dystroglycan
This glycosyl-transferase brings about the glycosylation of the alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix.
Statistics
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PSSM-Id: 464027
Aligned: 63 rows
Threshold Bit Score: 198.241
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015784606 106 DITLVTQSSLSELYNLLTIIHRWKGLISVGLFTLTRELSIAIEIILSLRKCYP-M--IRYNTSFHLVYPLlvplpdlnth 182
XP_016657117 246 SITYTTHADFTFLDNLEPLLERWRGPISVALYTPGNDFVPTLASIRYLRQCG--SplVAEYVTFHMYFGS---------- 313
EFA04866      29 SITVTTQGDFTFIENLLPLVERWQGPVSVALYAPGTDFDRTVASIRYLRECTN-Hi-IEKFVTFHIFFET---------- 96 
XP_015836630 100 SVTITTLGDFTFLDNILPMVERWKGPISVALHAPGTDFNAALDAIKHLR-CH--SalVREFVTFHIFFPS---------- 166
EEZ97185      80 SVTITTQGDFTFLENLPILVERWKGPISVALYAPGTDFKHTIDSIRYLRRCN--SplIAKFVTFHIFFDL---------- 147
EDW03074     106 SITYTTNGDFTFFDNLETLAERWFAPISFAIHTPGYDLNSTLDAIQYVRNCLPgSqmISDFVSFHIYFSH---------- 175
XP_002002758 115 SITYTTNGDYTFFDNLETIADRWFGPISFAIHTPGYDLNTTLDAIQYVRNCLPgSqlISDFVSFHVYFSN---------- 184
XP_002065394 145 SITYTTNGDYTFFDNLEMVAERWQAPISFAIHAPGYDLNSTLDAIQYVKNCLPgShyINDYVTFHVYFSN---------- 214
Q29KP0       124 SITYTTNGDYKFFDNLEMVAERWRAPISFAIHAPGYDLNTTLDSIQYVKNCLPgSeyINDYVTFHVYFSN---------- 193 Drosophila pseu...
EFX75183     162 SITYTTHGDITFLDNIVPLTRRWDGPLSVAVYTPGSDYESAIRSMAYLRQCT--GpdIRQRVSFHLVLDE---------- 229
XP_015784606 183 ydlirllpSEpsapslssssraesieeniC----AQLPKIMTALNPG--------------TLNYENE-GIPFPNNLLRN 243
XP_016657117 314 --------GHvpksvphtd-hdidapvanCs------APPPWTNa----------------SAAYKVQkKLLYPVNVGRN 362
EFA04866      97 --------EHtpetvsw------pegafdCa------QNPPFRESSA---------------QTYKAEnDLVYPINVGRN 141
XP_015836630 167 --------GHmppknl-------ktydfeDd------HECPETLll--------------pNSTYKSAhQLVFPINLARN 211
EEZ97185     148 --------EHvpkkifq------peegfdCd------RKNPPYHt----------------KTTYKTSqNLLYPINVARN 191
EDW03074     176 --------NHmpdyvpyde-eealnwpyqCveanGTLLEPPYRQn---------------sSTMYKVQaKMTYPINVGRN 231
XP_002002758 185 --------EHmpeyvpfde-eealnwpyqCvdenGTLLAPPYMQn---------------rRPMYKVQaNLTYPINVGRN 240
XP_002065394 215 --------LHmpvyvplne-advlnwpykCmeenGTLATPPYTQVPR--------------EAMYKVKaNLTYPINVGRN 271
Q29KP0       194 --------LHmpeyvpyde-aavlerpyfCelknGTKAPPPWTLip--------------rEAMYKMSaNLTYPINVGRN 250 Drosophila pseu...
EFX75183     230 --------RHfptvl----------rklhSq------QGPPTTRSPLqtsavnglstatpeTQDNKRTmNLTYPVNLLRN 285
XP_015784606 244 VARRNSLTQFVFVIDIDLVPNNNLNYDFIEFAK-----E---NRLfeEEtKDEKTIFVVPSYEIDSSL-VpdhiPKDKTE 314
XP_016657117 363 VARESATTHYVLPSDIELYPSPGVIEGFMDLVRr----Q---DPP--LR-RPKPMVFPLPIFELASHMkL----PADKKE 428
EFA04866     142 VAREMATTHFVLALDIELFPNPGFIPKFLDMIArdeppL----D----R--PYPRVFPLPVFEIKSGE-Ki---PENKSQ 207
XP_015836630 212 IAREMAQTHFIFPLDIELYPSPYLIPKFLKMIAq----N----G----P-WATPRVYPLAVFEIETGQkI----PDNKTQ 274
EEZ97185     192 IARKMSQTHFILPLDIELFPNPDFIPKFLSMIAr----N---QPP--LD-RPNPRVFPLPVFEIESGQkL----PDNKTQ 257
EDW03074     232 IARLAANTHFIFACDIELYPSLGFVDQFLDMVSl----N---NSVlaLRpDQARRVYPLAVFEVNENEsV----PNDKSE 300
XP_002002758 241 IARKAVNTHFIFACDIELFPSLGLIEQFLDMVHr----N---RSVlaLSpNQRPRVYPLPVFEIEENEqV----PNDKLE 309
XP_002065394 272 IARQASNTHFIFACDIELYPSVGFVEQFLDMVArnnsvLaldPK----Q---PRRVYPLPVFEIEAGQhV----PENKAE 340
Q29KP0       251 IARQAATTYFIFACDIELYPSLGFVEQFLDMVAa----N---HSIlaLDpQKPRRVYPLPVFEIESGApI----PNDKAE 319 Drosophila pseu...
EFX75183     286 VARQNAPTHYILASDAELYPSLDMVRLFFDMLRr----N---ESV--LH-LGRPKVFVLPIFEVYRNQtV----PSSKTE 351
XP_015784606 315 LmlavNSGYVRPFYYELCWKCQKYTDYEAWQK-EP---LSPKLDILFEVF-WHDPWEPFYISRNTVPMYDERFRQYG-FN 388
XP_016657117 429 LvsmlKNGSAITFHKKVCPDCHTVPKFKEWAS-AKp-kPGVSVFHTGKRTgYHLHWEPIFIGTHNDPLYDERLSWEGkMD 506
EFA04866     208 LremlDKNLAIYFHKDICYSCHKIPKFDQWKR-LNe-sQNFGVFRVVKRIhEHKHWEPFYVGTNAEPLYDERLSWEGrRN 285
XP_015836630 275 VqamlAKNLAVPFHHNICAQCHDIPKALKWQK-TAe-tPGLRVFYSAKRKgEYVHWEPFYITTHQEPLYDERFTWEGqKD 352
EEZ97185     258 LrkllSKNLAIPFHEKICPTCHNIPEFANWMK-TRe-tPNLGVFHVGKRNgRFFHWEPIFVGTNTDPWYDERLSWEGkKD 335
EDW03074     301 LltllGKGRAQIFHAKICKNCHKVPEYKSWINrAFnptDPLQLFSKTLRQgVYKYWEPFYVSDNTEPIFDERVTWEGqSN 380
XP_002002758 310 LldllQKRRAQLFHAKVCASCHKVPGYQRWINrTTpipDELQLFSMTLRQdTFRHWEPFYISDNKEPVFDERVTWEGqSN 389
XP_002065394 341 LldlyRNGLAQLFHAKVCPTCHKVPQQQLWMNrAPsvrDELKLFSMTLRRdKFRSWEPFYISDNTEPLFDERVTWEGqSN 420
Q29KP0       320 LlalyRDGRAQPFHMKMCFSCHTVPGQQDWLNrAPsvtDELRVWSVSLREkDFKYWEPFYVSDNQEPMFDERVTWEGqSN 399 Drosophila pseu...
EFX75183     352 LveklKAGLAVPFHQKVCSYCHSVPKSKEWLV-ANv-tDGLHVFHIAKRHkPYQRWEPIYIGTQDDPLYDERLTWEGkSD 429
XP_015784606 389 RISQVCELHMAGYRFSVLNNPFVIHK-GMKRPDSFH-KDKDLELEKNRILFR-HFKNELKDRYR 449
XP_016657117 507 KMTQGYTLCVLDYEFHILDNAFLTHKpGIK-TLKKD-PARQVLASKTYSLIKkVILPELKVLYG 568
EFA04866     286 KMTNGFILCVLDYDLMVLDNAFLVHRpGIKEKSAKN-ERRSKLVKETNKLIEqRILPEMKVLYG 348
XP_015836630 353 KLVQGFVLCILDYDFMILDNAFLVHKpGIK-VKTMD-ERRQAMTDLTDMSIKtEIMPQLEILFG 414
EEZ97185     336 KMTQGYVLCVQDYDFMILDNAFLVHKpGIK-TRNRDsERRKKIVKKTKEIIEgRILPQLGHLFG 398
EDW03074     381 KRIQGLAMCLLGYEYHVLHPAFLVHSpGIK-TSKLN-PVRQKYAKEMNRIIKkTIEPEYRVLYG 442
XP_002002758 390 KRIQGYAMCLLGYEYHVLHPAFLVHSpGIK-NSTRS-AVRAKYASEMTRFIKtKIEPEYRVLYG 451
XP_002065394 421 KRIQNFAMCLLGFEYHVLHPAFLVHSpGIKKQPSRK-SGRLKYAKAMTKFIKsKIEPEYRILYG 483
Q29KP0       400 KRIQNYAMCLLGYEYHVLHPAYLVHSpGIKKNASSK-SSRRTFAREMTRFIKkKVEPEYQVLYG 462 Drosophila pseudoobscura
EFX75183     430 KMTQGYALCVLDYDFMILDNAFLVHRpGVK-IPRRE-PLRDAMAKKQSAIIRsAIYRELKVLYG 491
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