Conserved Protein Domain Family
Mlo

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pfam03094: Mlo 
Mlo family
A family of plant integral membrane proteins, first discovered in barley. Mutants lacking wild-type Mlo proteins show broad spectrum resistance to the powdery mildew fungus, and dysregulated cell death control, with spontaneous cell death in response to developmental or abiotic stimuli. Thus wild-type Mlo proteins are thought to be inhibitors of cell death whose deficiency lowers the threshold required to trigger the cascade of events that result in plant cell death. Mlo proteins are localized in the plasma membrane and possess seven transmembrane regions; thus the Mlo family is the only major higher plant family to possess 7 transmembrane domains. It has been suggested that Mlo proteins function as G-protein coupled receptors in plants; however the molecular and biological functions of Mlo proteins remain to be fully determined.
Statistics
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PSSM-Id: 460801
Aligned: 34 rows
Threshold Bit Score: 603.494
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006850616   7 SRSLEETPTWAVAVVCFVMVLVSILIEHAIHLVGKWLTKRHKRALYEALEKIKAELMLLGFISLLLTIGQDTISRICISK 86 
XP_002892614   8 GRSLAETPTYSVASVVTVLVFVCFLVERAIYRFGKWLKKTRRKALFTSLEKMKEELMLLGLISLLLSQSARWISEICVNS 87 
EEF29044       9 GTTLEYTPTWVVALVCSVIVVISLAVERLLHYLGKLLKRKQQKPLFEALQKIKEELMLLGFISLLLTVFQGRINSICIPE 88 
CDY30455       5 GTSLEYTPTWVVALVCSVIVSISFAVERGLHRAGKHFDKNNQKQLSGALQKVKEELMLLGFISLLLSVSQSRIAKICISK 84 
O80580         5 GTTLEYTPTWVVALVCSVIVSISFAVERLIHRAGKHFKNNDQKQLFGALQKIKEELMLVGFISLLLSVGQSKIAKICISK 84  thale cress
XP_009382074  11 SRELDQTPTWAVAVVCAVIVVISILLEKGLHRFGEWLTEKHKKALFEALEKIKAELMILGFISLLLTFGQKYIVKICVPY 90 
O22752        30 GKELSQTPTWAVAVVCTFLILISHLLEKGLQRLANWLWKKHKNSLLEALEKIKAELMILGFISLLLTFGEPYILKICVPR 109 thale cress
O22757        38 HKQLNQTPTWAVAAVCTFFIVVSVLLEKLLHKVGKVLWDRHKTALLDALEKIKAELMVLGFISLLLTFGQTYILDICIPS 117 thale cress
EMS53724      10 SRELDQTPTWAVASVCGVIVLISILLEMGLHKVGEWFAHRKKKAMVEALEKVKAELMVLGFISLLLVFGQSYIIKICISE 89  Triticum urartu
XP_009391802   7 HESLEYTPTWVVAAVCTIIVVISLLVERFLHYLGKFLKHNQQDALYKALQKLKEELMLLGFISLLLTVFQRTISRICVSK 86  wild Malaysian ...
XP_006850616  87 SM-GDSLLPCRKNDQSingG---------------------EHVSESGDDdeg-----ssNR------------------ 121
XP_002892614  88 SLfNSKFYICSEEDYGihkK------------------------------------------------------------ 107
EEF29044      89 EM-SKKWLPCKEESETattT---------------------T-------------------------------------- 108
CDY30455      85 EL-SEKLLPCKKPKEDk-sL---------------------NDN------------------------------------ 105
O80580        85 EL-SEKFLPCTKPAGAeksL---------------------KDS------------------------------------ 106 thale cress
XP_009382074  91 KV-ADTMLPCSRKTDT---E---------------------TEEEADGRH----------RR------------------ 117
O22752       110 KA-ALSMLPCLSEDTVlfqK---------------------LAPSS---------------------------------- 133 thale cress
O22757       118 HV-ARTMLPCPAPNL----K---------------------KEDDDNGES----------HR------------------ 143 thale cress
EMS53724      90 AA-ADTMLPCRLKKATvevE---------------------IAKDGGHGApaggakeehgAKqpeehfslgtnpftatsf 147 Triticum urartu
XP_009391802  87 RL-FHHMLPCKENSFPpnqEvhrakglklqltwnnrkllseDE------------------------------------- 128 wild Malaysian ...
XP_006850616 122 ----RLLWLDDFDQphpSLRRVLAGS---KYDKCSPQGKVPLISYDGTHQLHIFIFVLAVFHVLYCISTMALGRLKMKRW 194
XP_002892614 108 ----VLLEHTSSTNqssLPHHGMHE----ASHQCG-HGREPFVSYEGLEQLLRFLFVLGITHVLYSGIAIGLAMSKIYSW 178
EEF29044     109 ----AHFQTFFSFIsggAPQRHLLAEssdSSSSCP-EGKVPILSTTALHHLHIFIFVLACVHVAFCALTILFGSAKIRQW 183
CDY30455     106 ----SHFQLSFT-------GRHLLAGdsgAGDYCSQKGKAPLMSISALHELHIFIFVLAIAHIIFCLLTILFGTMKIMQW 174
O80580       107 ----SHFQFSFT-------GRHLLAGdapAGDYCSLKGKVPIMSLSALHELHIFIFVLAVAHIIFCLLTIVFGTMKIKQW 175 thale cress
XP_009382074 118 ----RLLTNALTDPn--GKHRILAAG---SIVSC-SAGKVPLISTNGLHQLHILIFFLAVFHVASSFTTMALGRLKMRRW 187
O22752       134 -----------------LSRHLLAAGd--TSINC-KQGSEPLITLKGLHQLHILLFFLAIFHIVYSLITMMLSRLKIRGW 193 thale cress
O22757       144 ----RLLSF---------EHRFLSGGe-aSPTKCTKEGYVELISAEALHQLHILIFFLAIFHVLYSFLTMMLGRLKIRGW 209 thale cress
EMS53724     148 svphRMLSEATSFS---VPHRMLSEAn--MNTKCP-PGKVSLISINALHQLHIFIFFLAVFHVCYSATTMALGRAKIRGW 221 Triticum urartu
XP_009391802 129 -----------------------------GSDICMRQGKVPLLSLEALHQLHIFIFVLAVVHVVFCATTMVLGGAKIRKW 179 wild Malaysian ...
XP_006850616 195 KKWEQETKTIEYQWSH--DPERFRFARET-SFGRRHL-NFWTKSPILIWIVCFFRQFVRSVPKVDYLTLRHGFIMAHLAP 270
XP_002892614 179 RKWEAQAIIMAESDIH--AKKTKVMKRQS-TFVFHHAsHPWSNNRFLIWMLCFLRQFRGSIRKSDYFALRLGFLTKHNLP 255
EEF29044     184 KHWEDSVTKGEYDQEE----ARLTHVQDH-DFIKKRFkGIGKNSYLLGWVHSFFKQFYGSVTKSDYITLRLGFIMTHCRG 258
CDY30455     175 RKWEDKVLEKDYNADEv-IQKKYTAVREH-DFIRGRFlGVGKADACFGWVHSFMKQFLASVNESDYITMRLGFVTTHCKT 252
O80580       176 KKWEDKVLEKDFDTDQ--SIKKFTHVQEH-EFIRSRFlGVGKADASLGWVQSFMKQFLASVNESDYITMRLGFVTTHCKT 252 thale cress
XP_009382074 188 KHWESEISSPEYEFSK--DPSRFRFTHET-SFVRRHT-SIWNRVTICFYFVSFFRQFFRSVCKADYLALRHGFINVHLAP 263
O22752       194 KKWEQETLSNDYEFSI--DHSRLRLTHET-SFVREHT-SFWTTTPFFFYVGCFFRQFFVSVERTDYLTLRHGFISAHLAP 269 thale cress
O22757       210 KHWENETSSHNYEFST--DTSRFRLTHET-SFVRAHT-SFWTRIPFFFYVGCFFRQFFRSVGRTDYLTLRNGFIAVHLAP 285 thale cress
EMS53724     222 KEGEKEAAGQDEEVTN--DPSQFRFTHET-SFVRQHM-NVLNKTPASFYISNFFRQFFRSVRRADYCALRHSFVNVHLAP 297 Triticum urartu
XP_009391802 180 KLWENDIRKGQPKKETlsAEELSTHVQQHnEFVMEHTeGLQQRSVVLSWIMSFLKQFYASVTKSDYIALRSGFIMKHCSS 259 wild Malaysian ...
XP_006850616 271 QSStkFDFHKYIKRSLEEDFKVVVGISPIIWFFAVVFLLFNTHGWYSYLWLPFIPLIIILLVGTKLQVVITKMGLKIQDR 350
XP_002892614 256 FT---YNFHMYMVRTMEDEFHGIVGISWPLWVYAIVCICINVHGLNMYFWISFIPAILVMLVGTKLEHVVSKLALEVKEQ 332
EEF29044     259 NPK--FNFHKYMMRALEADFKKVVGISWYLWLFVVIFLLLNVAGWHAYFWIAFIPFVLLVAVGAKLEHVITQLAHEVAEK 336
CDY30455     253 NPK--FNFHKYLIRALNSDFKKVVGISWYLWVFVVLFLLLNIAAWHVYFWLAFLPLILLLAVGMKLEHIITDLAHEVAEK 330
O80580       253 NPK--FNFHKYLMRALNSDFKKVVGISWYLWVFVVLFLLLNIVAWHVYFWLAFIPLILLLAVGTKLEHIITDLAHEVAEK 330 thale cress
XP_009382074 264 GSK--FNFQKYIKRTLEDDFKMVAGISPVLWASAVIILLLNVHGWKEKFWASIIPLVTILAVGMKLHVIITRMAIEIEER 341
O22752       270 GRK--FNFQRYIKRSLEDDFKLVVGISPVLWASFVIFLLFNVNGWRTLFWASIPPLLIILAVGTKLQAIMATMALEIVET 347 thale cress
O22757       286 GSQ--FNFQKYIKRSLEDDFKVVVGVSPVLWGSFVLFLLLNIDGFKMMFIGTAIPVIIILAVGTKLQAIMTRMALGITDR 363 thale cress
EMS53724     298 GSK--FDFQKYIKRSLEDDFKVIVGISPILWASALTFLLININGLHSMLWISIMPLVIILLVGTKLQGIICRMAIDITER 375 Triticum urartu
XP_009391802 260 NPD--FDFHKYMLRTLEDDFKIVVGIRWYLWLFVVLFLLLNVNGWHTFFWLSFLPLVLLLAVGTKLEHIITCLAQEAAEK 337 wild Malaysian ...
XP_006850616 351 GDVVKGVPVVQPTDKLFWFNQPRLILYLIHFVLFQNAFQLAFFTWTWYEFGLRSCFHKHLEDVIIRISMGVLIQFLCSYV 430
XP_002892614 333 QTGTSNGAQVKPRDGLFWFGKPEILLRLIQFIIFQNAFEMATFIWFLWGIKERSCFMKNHVMISSRLISGVLVQFWCSYG 412
EEF29044     337 HIAVEGDLVVQPSDDHFWFHRPRIVLILIHIILFQNSFELAFFFWIWVQYGFDSCIMEEVGYLIPRLIIGVFIQFVCSYS 416
CDY30455     331 HIAVEGDLVVRPSDDLFWFKSPRLVLFLIHFILFQNSFELAFIFFIFAQYGFDSCIMGQVKFIIPRLVIGVLVQLLCSYS 410
O80580       331 HIAVEGDLVVRPSDDLFWFQSPRLVLFLIHFILFQNSFEIAYFFFILFQFGWDSCIMDHVKFVIPRLVIGVIIQLLCSYS 410 thale cress
XP_009382074 342 HTVIQGIPLVQLSDHHFWFGRPYFVLFLIHFALFQSAFQITYFFWIWYEFGLKSCFHENFVSIIVKVIIGVLVQFFCSYI 421
O22752       348 HAVVQGMPLVQGSDRYFWFDCPQLLLHLIHFALFQNAFQITHFFWIWYSFGLKSCFHKDFNLVVSKLFLCLGALILCSYI 427 thale cress
O22757       364 HAVVQGMPLVQGNDEYFWFGRPHLILHLMHFALFQNAFQITYFFWIWYSFGSDSCYHPNFKIALVKVAIALGVLCLCSYI 443 thale cress
EMS53724     376 HAVIQGIPLVQVSDSYFWFSRPTFVLFLIHFTLFQNGFQIIYFLWILYEYGMDSCFNDSKKLVFARLCLGAVVQVLCSYV 455 Triticum urartu
XP_009391802 338 PTDGQ-VPKVKPSDHHFWFNQPGILLYLIHFILFQNAFELAYFFWIISTYGFYSCIMEKVGYIIPRLLVGVIIQVLCSYS 416 wild Malaysian ...
XP_006850616 431 TLPLYALVTQMGSNMKTTVFDDRVAAALRKWHHTAKKHIK-EGRKS-ASV--------TP--FSSRPGTPLhpsaggEGL 498
XP_002892614 413 TVPLNVIVTQMGSRHKKAVIAESVRDSLHSWCKRVKERSK-HTRSV-CSLdtatiderDEmtVGTLSRSSSmtslnqITI 490
EEF29044     417 TLPLYAIVTQMGSSFKKAIFDEHIQTGLVGWAKQVKKKMVlRKAAN-GS---------TQ--VSKKED----------SP 474
CDY30455     411 TLPLYALVAQMGSSFKGAIFTDQAQQQIAGWAKSAK-----MAKKK-GS---------TH--AGSSHGG-SpnpiatPSP 472
O80580       411 TLPLYALVTQMGSSFKGAIFNEQTQEHLVGWAKMAK-----RGVKK-GA---------TQ--VGTSHDATSpr------- 466 thale cress
XP_009382074 422 TLPLYALVSQMGSHMKRSIFDEETSKALIKWHQIAKKKQE-KGLSR-SSSvhepsstmSP------------------QA 481
O22752       428 TLPLYALVTQMGSHMKKAVFDEQMAKALKKWHKDIKLKKG-KARKL-PSKtlgvsesfSL-----------------SSS 488 thale cress
O22757       444 TLPLYALVTQMGSRMKKSVFDEQTSKALKKWRMAVKKK---KGVKA-TTKrlggdgsaSP------TASTV------RST 507 thale cress
EMS53724     456 TLPLYALVSQMGTTMKQSIFDDQTSKALKSWRAGVKKKPAaNSKHGsGSPs------gSP--RAGSPKAGD------EGS 521 Triticum urartu
XP_009391802 417 TLPLYTIVTQMGDMFKQAIFDELLRSTLHGWAETIRKRKEpKTFGV-SS---------FMkvINSKSKTSV-------SG 479 wild Malaysian ...
XP_006850616 499 S-PVHLLRHY 507
XP_002892614 491 N-SIDqaesi 499
EEF29044     475 G-SVQLSHAG 483
CDY30455     473 K-SIQLQSLL 481
O80580       467 -pSIQLNSLL 475 thale cress
XP_009382074 482 S-PVNPMQrs 490
O22752       489 S-SATTLHRS 497 thale cress
O22757       508 S-SVRSLQRY 516 thale cress
EMS53724     522 TaGIALTQKq 531 Triticum urartu
XP_009391802 480 S-RIQMQnti 488 wild Malaysian banana
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