Conserved Protein Domain Family
Focadhesin

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pfam11229: Focadhesin 
Focadhesin
Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor function in gliomas. The structure prediction indicates that it consists in repetitive alpha hairpins that adopt an armadillo-like fold.
Statistics
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PSSM-Id: 463242
Aligned: 13 rows
Threshold Bit Score: 1012.72
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007668745  479 MNKIRMLTEKNQQTPGFALALGNLVHGLSVCGHGKAEDLSNKLLPPWIKIVLTEGSSTMQCLAALNGLVSLVGSEGVLFQ 558 
XP_014351073 1167 INKLRALTEQNQQTPGFALALGVIVNGLAVCGHGKAEDLSNRLLPAWIKILLAEGCSTMQRLAAVNGLVTLLGSETSLIQ 1246
XP_022534022 1211 MNVLRSVTEESQQTPGFALALGLTVHGLSSCGHGKAEDIHPRLLAAWTKILLAEGCPTMQRLAALNGLIALVGSETGLLQ 1290
XP_009301365 1221 MNTLRALTEESQQTPGFALALGQTVFGLSSFGHGKAVDIQPRLLAAWTKILLAEGCPTMQRLSALNGLIALVGSETALIQ 1300
XP_019204834 1217 MDTLRSLTEESQQTPGFSLALGLAVHGLSVSGHGRAEHIHPHLLAAWIKILLAEGCPTMQRLAAVNGLVALVGSESYLIQ 1296
2_pfamImport    1 MKALRCLTEDNRQAAGFSMALGMLVHGLAACGHGKAEEAQPHLLASWMKTLLTEGCPTMHRLAALSGLLALVGSEANVFQ 80  
XP_016870346 1178 MNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRIVLTEGTPTMLCLAALHGMVALVGSEGDVMQ 1257
XP_007498130 1216 MNKLRTLVENNQQNSGFALALGNIVHGLSVCGHGKAEDLSNRLLPAWIKIVLTEGSPTMQCLAAVNGLVALVGSEGAIMQ 1295
XP_027302524 1188 MNKLRTLVEDNQQTSAFALALGTIVHGLSVCGHGKAEDLRNKLMPAWIKTLIAEGSPTMQRLAAVNGLVALVGSEGGMIQ 1267
XP_003216652 1216 MNKLQKLTESNQQTAGFALALGNIVHGLSVCGHGKAEDLGNRLFPAWMRILLAEGAPTMQRLAAINGLVSVVGSEGTMIQ 1295
XP_027143816 1219 MNTLRSLTEESQQTPGFSLALGLVVHGLSMSGHGKAEDIHPRLLAAWIKILLAEGCPTMQRLAAVNGLVALVGSESYLVQ 1298 large yellow ...
XP_011604804 1212 MNTLRNLTEESQQTTGFSLALGMVVHGLSMCGHGKAEDIHPHLLASWMKILLAEGCPTMHRLAAVSGLVALVGSESCIIH 1291 torafugu
XP_015200548 1031 MNNLRLMTEKSQQTPGFALSLGITVHGLSACGHGKAEDFYFRLLGAWIKILLTEGCPTMQRLAAVNGLVALVGSESSLIQ 1110 spotted gar
XP_007668745  559 MKSDPIQSSQFQGKLKEVIRTIIQLTNLSAVIGVQSNAVWLLGHLHLSSLSANQSRASVPADFSYLSENSFIRAAIDFLI 638 
XP_014351073 1247 LKSETIQSSQFQSKLNEVIRTITQIISFSGVIGLQSNAAWLLGHLHLANLSASQSRTSVPPDFSYLSEKSVIRAATDYIV 1326
XP_022534022 1291 LKSETEQSSQQQARLNEVIRSITQIISFSGAIGLQSNGACLVGHLHLAHMSSSHSRTAVPQDFSYLPERSLIRASVEYIT 1370
XP_009301365 1301 MKSECEETSLQHSRLNEVIRAITQIITFSGTIGLQSNGACLLGHLHLTHASSRHSRTAVPQDFGYLSESSVIRASVDFIT 1380
XP_019204834 1297 LKSETELVSKQQNRLNEVIRAVTQIITFSGAIGLQSNSACLLGHLHLAHMSSSHSHTAVPPDFSYLSEKSVVRSTTEFIT 1376
2_pfamImport   81 LEAELEASSQQQSRLNEVIRAVTQVITLSGAIGLQSNCACLLGHLHLSQVSNSPRPGAAPQDFSYLPERSVLRWVVSFLT 160 
XP_016870346 1258 LKSEAIQTSHFQGRLNEVIRTLTQVISVSGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFI 1337
XP_007498130 1296 LKSETIQASHFQSQLNEVIRTITQVISFSGVIGLQTNAAWLLGHLHLSSLSSSQSRTSVPADFSYLPENSFIRAAVDFII 1375
XP_027302524 1268 LKSESIQSSQFQSMLNEVIRTLTQIISFSGQIGLQTNAAGLLGHLHMSCLSSTQSRASVPPDFSYLPENSFIRAAIDFAI 1347
XP_003216652 1296 LKTEAIQSSQFQSKLNEIIRTLSQIISFSGVIGLQTNAAWLLGHLYLSTVSATCSRTSVPPDFSYLPEKSFLRAAIDFVI 1375
XP_027143816 1299 LTSELELSSQQQSRLNEVIRAITQVITFSGAIGLQSNSACLVGHLHLAHMSTSHSHTAVPQDFSYLSEKSVIRSIVDFLT 1378 large yellow ...
XP_011604804 1292 LKSELEISSQQQSRLNEVIRAVTQVVTLSGAIGLQSNSACLLGHLYLAHMSNSCSHSSVPQDFSYLPEKSVIRSVATFLT 1371 torafugu
XP_015200548 1111 LKSESGQSPQQQSRLNEVIRAITQVITFSGAVGLQSNASCLVGHLHLANLSLGQTRTSVPPDFGYLSERSVIRAAVDYLI 1190 spotted gar
XP_007668745  639 DGGKKG---PESVPASCVKTVMKPIVTVGKSYQYPPVNWASLLSPLLRLNFGEEVQLLCIQLMVTQAQSSQNAAMLLGMW 715 
XP_014351073 1327 EAGKKG---PETIPSQMIKVILGSIATAGSSYQYPPVNWAAILSPLMRLNFGEEIQRHSIEIAVTQAQSSQSATMFLGMW 1403
XP_022534022 1371 EAGRKG---PEFFPPDGIKVVLAPLATVGDNFQYPPVNWNAILSPMMRLNFGEEVQHHCLELAANQAQSSPSAALFLGVW 1447
XP_009301365 1381 EAGRKG---PEFTAPQRVKTLLSALAAVGADFQYPPVNWSSVLSPLMRLGFGEEVQHYCLELAASQTQSSQSASLFLGVW 1457
XP_019204834 1377 EAGQTG---PQSSHPGLVKTALTALASVGASFQYPPINWSAALSPLMRMSFGEDVQHQCVVLAACQTQSSHSAALFLGSW 1453
2_pfamImport  161 EAGRKG---PDEVRPPPVLTALSSLASVGARFQLPPINWGLPLAPLMRLGFGEDVQHECLALAASQAPWSQSAAVFLDSW 237 
XP_016870346 1338 TGGKKG---PESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAALLGLW 1414
XP_007498130 1376 EGGKKG---PESVPPSLVKVAMKPIATVGENYQYPPVNWASLLSPLMRLNFGEEVQQLSIEIMVTQAQSSQNAAMLLGMW 1452
XP_027302524 1348 ESGKKG---PESVPAQLLKVALAPIAIVGESHQYPPVNWASVLSPLMRLNFGDEVKHLCLELAVTQAQSSQNAAMLLGMW 1424
XP_003216652 1376 EAGKKG---PEKVQPSLVKAAMVPIALIGEKYQYPPVNWAALLSPLLRLDFGDEVQQLCIKLAVTQAQSSQNAAMLLGMW 1452
XP_027143816 1379 EAGKKG---PEFAHPALVKTALTPLASVGSSFQYPPINWSAVLSPLMRLSFGEDVQHQCVVLAACQAQSSQSASLFLGSW 1455 large yellow ...
XP_011604804 1372 EA---GkkgPDFVHPVLVKTAVTSLASVGAGFQFPPVNWSVSLSPLMRLGFGEDVQHQCLVLAASQAHSSQSAALFLGSW 1448 torafugu
XP_015200548 1191 EAGRKG---PEHLHPKLVNVVLGPLASVGSSFQYPPVNWGAILSPLMRLNFGNTVLFI-----------MSSIRFFYY-- 1254 spotted gar
XP_007668745  716 VIPPLVYSLSVKSRKYLFGSLSLWMKYVSVEQLQVFTKVFIVQHFEAKNRDQNPELCQESLEGLSQAMKIPNPAQHLWNP 795 
XP_014351073 1404 LTPPLVHSLSMSTKKYLCSSVSLWMKQVPEDKLQLFAKKFGAQYFTAGNRHQNPDFCQVILEGLSQAMELPNPAQFCWSI 1483
XP_022534022 1448 LAPPLVHSLSLRTRALLYECLCSWMKHVAEDKLQVYVESLAVQQFNPDTRAQRHPLCLAILQGLAKAMSLPNPAQNCWSS 1527
XP_009301365 1458 LVPPLVHSLSLRTRAHLYESLSCWMKHVAEDKLQVYVDSLAVQQFEPLTRLQRLSLCLSILHGLSRAMTAPNPPQNCWSV 1537
XP_019204834 1454 LSPPLVHSLSYQTRAHLYETLGSWMKHVTEDKLQVYVESLGVQQFQEDLRPQRASLCCSVLRGLAQAMALPNPSSSCWTI 1533
2_pfamImport  238 LSPPAGPQSQGATRAHLYESLGSWMRHVGEDKLQAFVEQLGVQLFREE---RAAPVCQALLRGLAQAMALPNPPKHCWAL 314 
XP_016870346 1415 VTPPLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVFKAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSL 1494
XP_007498130 1453 VVPPLIHSLNLKTKKYLLASLPLWMKHVSEDQLQVFTEVFMVQLFEASLAVQDPELCQSALQGLSQAMKLPSPAQYLWSQ 1532
XP_027302524 1425 VAPPLVYSLSVKTQKYLLVSLPLWMKHVAEDKLQSFTEVFLTQQFEMKSHTKETEICQCVLQGLMQAMKIPNPAQYCWSF 1504
XP_003216652 1453 VAPPLVYSLSIQAKRYVFTSLPVWVKYVADDKLQAFTEIFMVQHFDTKKQAKNRELCWDILQGLHQAMKLPNPAQGNWSC 1532
XP_027143816 1456 LSPPLVHSLSYQTRAHLYESLGLWMKHVAEDKLQVHVESLGLQQFQEDLRPQRLSMCRSVLQGLAQAMALPNPPNNCWTI 1535 large yellow ...
XP_011604804 1449 VSPPLVHSLSHPTRVHLYESLGLWMKHVAEDKLQVYVDKLGLQHFQDKQNPHSLSMCQSLLRGLAQAMALPNPPKHCWTV 1528 torafugu
XP_015200548 1255 LIP------HLKTRAYLYKSVSVWMKHVPDDKLQSFVEVLGVQHLTASSRQQSPDLCVAVLEGLEQAMKLPNPTQFCWGV 1328 spotted gar
XP_007668745  796 LCQAAEKIFDILPNKIQRNEVDLYVMIAKCLAEMTDAEINRIFRITESNIEKTVFVRVYLISQGRFSLMSLNNVIDAVLE 875 
XP_014351073 1484 LCKTVEKIFELLPNKIQRSEVELYIKLSKCLSEMADTEIDRITQVSKDNIEKATFIRAYLVSQGRVPLLSLNDILGTAVR 1563
XP_022534022 1528 LCTTTEKIYNLLPDHIQPSEVELYEGICSCLSEMSDTEIDRIVKVTEANVEKTTFILSYLSSKGRIPLLGLNDIISTVLQ 1607
XP_009301365 1538 LCSTAEKIYNLLPDSIPAAEVALYEAMCSCLSEMSDAEIDRIVKVSEANVEKTAFILSYLVSKGRVPLLGLNDVISTILQ 1617
XP_019204834 1534 LCSATEKIFTFLPDRIQDNEVDLYVGVAKCLSEMSDTEIERIMKVSETQMEKTCFILAYLTSQGRVPLLSLNDVIAGVLR 1613
2_pfamImport  315 LCSTTEKIYSILPDPKQEDEVGLYVGLARCLSEMSDTEIERITRVTEAGMEKSCLVLAHLTSEGRLPLLALNDVVAGALR 394 
XP_016870346 1495 LSEATGKIFDLLPNKIRRKDLELYISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQ 1574
XP_007498130 1533 LCWATEKIFDLLPNKIRRSDVDLYINAAKCLSEMTDAEIDRITHITKNNIKKAAFVKVYLVSQGRFPLMHWNDVIEVAVR 1612
XP_027302524 1505 LCQAAEKIYELLPNYFQRGELEMYVSVAKCISEMGDSEIDRIVQISKNNIEKAIFTKLYLISQGRLPLMNLSAMIYALTG 1584
XP_003216652 1533 LCKATERIFELLPNEIRQNEVKMYINSAKCLSEMTDTEVDQITQVSKNNLEKITFVKLYLVSQGRFPLLRWNDVISTAAG 1612
XP_027143816 1536 LCSTTEKIFTLLPNQIQDDEVDLYVGVTKCLSEMSDTEIDRIARVTENQMEKTCFILAYLTSQGRVPLLGLNDIIAGVLR 1615 large yellow ...
XP_011604804 1529 LSSTTEKIYSILPNQIQDNEVGLYVGLAKCLSELCDTEIDRITRVTEDRMEKAAFILAYLTSKGRLPFLGLNDVISGIRC 1608 torafugu
XP_015200548 1329 LRSTTERIFMLLPDEVQDDEVELYVRIATCLSEMEDTEIDRITRVTKANLVKTGFTMAYLVSQGRVPLLGLNDVIAAAIG 1408 spotted gar
XP_007668745  876 CDQRETVAWMILHSFY-HARIVSHPNTGVLKRLEWMLELMGIIRSVAYQSKPVQ--NVTLEKAVDFLFQIFAALVVAWGD 952 
XP_014351073 1564 CNQTEAVSWMLLQCFY-QARLIAHQNTGVMTRIEWLLELMGHIRNVASGTTPLE--NTDLKRAVDFLLQIFAVSVVAWAD 1640
XP_022534022 1608 KGKTERISWLFLQCLY-QSRLASSPNTGVSKRMEWLLELMGHIRKVTYGA-SVK--CNRVREGTDFLLEVFAAAVVSWAN 1683
XP_009301365 1618 VGSKRPISWLLLQGLH-QSRFASGPNTGVSKRMEWLLELMGHIRNVAYGSPSVK--CVDVLQGTDFLLGVFAAAVVSWAD 1694
XP_019204834 1614 GWPSRRVGWLLLQTFY-QCRLATSINTGISRRMEWLLELMGHIRNVAYGVTDVQ--CGDTRSATDFLFQLFAAAVVSWSD 1690
2_pfamImport  395 GWPSRRVGWILLQALHrHHHRAAKPGTGVSQQMGWLLELMGHLRSVTCGGSSHL--RGDASAATDFLFQVVAGAVVAWGD 472 
XP_016870346 1575 HREKEVLAWMILHSLY-QARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFH--NTALDKALDFFLLIFATAVVAWAD 1651
XP_007498130 1613 CQDRETVAWMMLHGLY-HARIISHANTGVLKRMEWLLELMGYIRNVAYKSTSVE--NVALEEAINFLLLLFAASVVAWGD 1689
XP_027302524 1585 CYQKESIAWMFLHSFY-HARIVSHENTGVLKRMDWLLDLMGYIRNLAFKSTPIQ--NVDLKEFIDFLLWLFAASVVAWAD 1661
XP_003216652 1613 CQEKETIVWMLLHSFY-HARIVSHENTGVLKRMEWLLELMGYIRNVSLKTTSVP--NVAPKEALSFLVWIFAAAVVAWAD 1689
XP_027143816 1616 GWSSRRVGWLLLQTFY-QCRLATGSNTGVLKRMEWLLELMGHIRNVAYGATPVI--CGDTKLATDFLFQVFAAAVVSWGD 1692 large yellow ...
XP_011604804 1609 GWPGHRVGWILLQAFY-QCHRGTNPSTGVSQQMEWLLELMGHIRNIAYGG--KAepSGDTSAATDFLFHVFAAAVVSWGD 1685 torafugu
XP_015200548 1409 SCHQEAVSSLLVRSFY-QSRLAASPNTGVLKRMEWLLELMGHIRNVAYGSTPVE--NGDVKQATDFLLQLFCAAVVSWAD 1485 spotted gar
XP_007668745  953 HATPLLLGFSASWLSWHKEHGessFAACSPNYLGHSPLNRLTLKETLTLLPNSMHLLLTKEPWKEHTPKFIDWLFNILES 1032
XP_014351073 1641 HTTPLLLGVSANWFPWKQEEAk--TANCPVNFLGCCSLNVLSVQGCLTVLPCSIQLLLAKEPWKEHTQKFIDWLFSIWES 1718
XP_022534022 1684 HSTPVIVGVRAQWFPWRQFSAe--YPDVPRGLYVNSVSTDESVKQCVLAVPYALKLLLDKEPWKSQSQKFIDWLFSITEA 1761
XP_009301365 1695 HGGPLLVGIRARWFPWPQSAE------LCHGLYANPEDTELPVASCLLAIPYSIRKLLDKEPWKSQSQKFIDWLFSITEA 1768
XP_019204834 1691 HIMPLLFGIRVQWFPWQPDPK---PHALTHGLYGEESLVEGALSQCLLAMSHSLPRLLDKEPWSSQTPKFIDWLLSIMEA 1767
2_pfamImport  473 HVVPLLLGLGARWLPWQPQAR---PCFPEH---GQEARAEEALAQCLPGMPLSLARLLSTEPWSSQTDKFIDWLLTITEG 546 
XP_016870346 1652 HTAPLLLGLSASWLPWHQENG---PAGPVPSFLGRSPMHRVTLQEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMES 1728
XP_007498130 1690 HDAPLLLGLSASWLPWHHEGG---VAGSSPGYLGQSPNNKVTLQETLTLLPSSMLLLLSKEPWKEQTQKFIDWLFSIMES 1766
XP_027302524 1662 HGAPLLLGLSASWSSWNHQTV---LPELSKDHIGKHSTDKIAVQETLTLLPSSIFLLLAKEPWKEQTQKFIDWLISMVES 1738
XP_003216652 1690 HAAPLLLGLNADWSLWEGKA----VPGVSPSLLGRQPIDNLAVQETLTLLPGSLQTLLSKEPWKEQTHKFFDWLFSIMEA 1765
XP_027143816 1693 HFMPLLLGIRSQWFPWQPDSK---PQTLRHSLYGQESVTDNVLPQCLLGMSHSLSLLLDKEPWSNQTHKFIDWLLSITEG 1769 large yellow ...
XP_011604804 1686 HVVPLLLGVRATWLPWQPESK---PQILEHSLYGEESHVGNALPHCLLGMPLSLAQLLSKEPWSSQRHKFIDWLLSITEG 1762 torafugu
XP_015200548 1486 HSLPLLLGIGAKWLPWKEDNA---VPSSPQARFGNSSADEQLALQCSKGLPYSIQLLLAKEPWKGQTHKFIDWFFSILEC 1562 spotted gar
XP_007668745 1033 PKEALSASTRDILKATLLALRFLPECKRKVVWTKVCGW 1070
XP_014351073 1719 PKKVLSETSKNVLKATLLNLRFLPEFKKKAVWTRAYGW 1756
XP_022534022 1762 PEEVLSPTAISTARAALLALKSNPEFKKKTVWTRAYGW 1799
XP_009301365 1769 PKQAFSETAVLTAKAALMALRSSSEFKKKTVWTRAYGW 1806
XP_019204834 1768 PEQSVSASTVSTAKAALLGLRSSAEFKKKAVWTRAYGW 1805
2_pfamImport  547 PEQSFSVGVVATAKASLLALQSFPGFQKKAVWTRAHGW 584 
XP_016870346 1729 PKEALSAQSRDLLKATLLSLRVLPEFKKKAVWTRAYGW 1766
XP_007498130 1767 PQEALSSSSRDLLKATTLALRFLPEFKKKVVWSRAYGW 1804
XP_027302524 1739 PKEALSKSSTDLLKATLLALRSLAEFKKKAVWTKAYQW 1776
XP_003216652 1766 SNEVLSKSSRDLLKASLLALRSFPEFKKKAIWTKAYGR 1803
XP_027143816 1770 PEQCLSAVTVSTAKAALLALRSSAEFKKKAVWTRAYGW 1807 large yellow croaker
XP_011604804 1763 PEKSFSVAVTNAAKAALLALNSVPEFKKKLVWTRAYGW 1800 torafugu
XP_015200548 1563 PKQGLSERSIRTVKGALLALRYLPEFKKKVVWTRAYGW 1600 spotted gar
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