Conserved Protein Domain Family
Dpy19L1

?
cd20178: Dpy19L1 
C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1)
Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L1 (also called protein Dpy-19 homolog 1) regulates neurite extension during development.
Statistics
?
PSSM-Id: 439131
Aligned: 5 rows
Threshold Bit Score: 1237.03
Created: 6-Feb-2019
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
XP_006005635  34 KIVTTLLLAAVAGILHWQHISRLFENDRHFSHLStLEREMTFRTEMGLYYSYFKIIIEAPSFshGLSMIMNDRLTEYPLA 113 coelacanth
PWA33139     242 SLAVTVLLAGLTGYLHWYHLSQLFENDRHFSHLSnLEKEMAFRTEMGLYYSYYKTIIEAPSFldGLHVIMNDRLTEYPLV 321 western mosquit...
PKK20981      78 KIWLTFLLAALAGVLHWCHITTLFENDRHFSHLStLEREMAFRTEMGLYYSYFKTIIEAPSFwnGVWAIMNDRLTEYPLV 157 rock pigeon
A6X919        90 RTWSTLLLASFAALLHWSHITHLFENDRHFSHLStLEREMAFRTEMGLYYSYFKTIVEAPSFlnGVWMIMNDKLTEYPLV 169 house mouse
Q2PZI1        19 RAPRGRRRAVFAAVLHWSHITHLFENDRHFSHLStLEREMAFRTEMGLYYSYFKTIVEAPSFlnGVWMIMNDKLTEYPLV 98  human
Feature 1                                                                                        
XP_006005635 114 INTLKRFNLYPEVVLAGWYRMYTgtmeffgsqtkmcwtvhrgqglepvksceglgdPAYFYVTFVFILNGIMMSVFFIYG 193 coelacanth
PWA33139     322 INTLKRFNLYPEVVLASWYRMYTgvmgffgiptktcwsinrgegltpvdsceglgdPAYFYVACVFLLNGAMMSIFFIYG 401 western mosquit...
PKK20981     158 INTLKRFNLYPEVVLASWYRIYTalmdflgvptktcwtvnrgkglspvesceglgdPASFYVAVIFLLNGLMMSLFFIYG 237 rock pigeon
A6X919       170 INTLKRFNLYPEVILASWYRIYTkimdligiqtkicwtvtrgeglspiesceglgdPACFYVAVIFMLNGLMMALFFIYG 249 house mouse
Q2PZI1        99 INTLKRFNLYPEVILASWYRIYTkimdligiqtkicwtvtrgeglspiesceglgdPACFYVAVIFILNGLMMALFFIYG 178 human
Feature 1                                                                                        
XP_006005635 194 tFLSGSRLGGVVTVSCFFFNHGECTRVMWTPPLRESFSYPFLIVQMLLVTFILRSsrtgkSTLAALCVANVLFMLPWQFA 273 coelacanth
PWA33139     402 vYLSGSRLGGIVSTLCFFFNHGESTRVMWTPPLRESFAYPFLVLQMLLLTYILRVrnpgrTAMVALGISNLCFMLPWQFA 481 western mosquit...
PKK20981     238 tYLSGSRLGGLVTVMCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLLTYILRIpnintGSLIALCVSNIFFMLPWQFA 317 rock pigeon
A6X919       250 tYLSGSRLGGVVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTHILRApelcrGSLIALCISNVLFMLPWQFA 329 house mouse
Q2PZI1       179 tYLSGSRLGGLVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTHILRAtklyrGSLIALCISNVFFMLPWQFA 258 human
Feature 1                                                                                        
XP_006005635 274 QFVLLTQIASLFTAYVVGYVgsdklenILYAHMISLLVCFVLMFGNAMLLTSFYASSLLTIWGVltyrqkllafckneiv 353 coelacanth
PWA33139     482 QFVLLTQVASLFASYILGYLaaakmqsILVTHMITLGVCFVLMFGNSMLLTSFYASSLISIWVIialrnqfiqvfkpgvi 561 western mosquit...
PKK20981     318 QFVLLTQIASLFAVCIMGYIdscklqkILIAHMRSLVVCFILMFGNSMLLTSYYAASLVVIWGIlelspkvlkssrrevy 397 rock pigeon
A6X919       330 QFVLLTQIASLFAVYVVGYIdthklqkIIYMHMISLVLCFVLMFGNSMLLTSYYASSLVIIWGMlamkpqflrmnvsels 409 house mouse
Q2PZI1       259 QFVLLTQIASLFAVYVVGYIdicklrkIIYIHMISLALCFVLMFGNSMLLTSYYASSLVIIWGIlamkphflkinvsels 338 human
Feature 1                                                                                        
XP_006005635 354 aWVVQGFAWFIGTIILKVFSskvlgiADDAHISNllkSKFTSyKDFDTLMYTCAAEFDFM--------EKETPLKYTKTL 425 coelacanth
PWA33139     562 lWVMQGLAWVGSTVLLKFLLssvfgaSDDAHISGlikSKFTSyKDFHTLMYTCAAEFDFMefeasykkMIRTPVRYLKTL 641 western mosquit...
PKK20981     398 iWVIEGCAWLFGTVTLKYLTslvlgiADDAHIGKilkSKFIGyKDFDTLMYTCAAEFDFM--------EKETPVRYTKTL 469 rock pigeon
A6X919       410 lWVIQGCGWLFGTVILKSVTsrifgiADDAHIGNlltSKFFSyKDFDTLLYTCAAEFDFM--------EKETPLRYTKTL 481 house mouse
Q2PZI1       339 lWVIQGCFWLFGTVILKYLTskifgiADDAHIGNlltSKFFSyKDFDTLLYTCAAEFDFM--------EKETPLRYTKTL 410 human
Feature 1                                                                                        
XP_006005635 426 LLPVVLCVFCTIAAKTSKTLWkflkkkkpegpgpdlsgdgrqkehfaqGEVVYNALQLIAFAVLALLIMRLKLFLTPHMC 505 coelacanth
PWA33139     642 LLPVNMLVVALIASKTMLDLFrtltqkaktspnmededeftgcdaaakGELVYHSLQLVAFAVLAILIMRLKLFLTPHMC 721 western mosquit...
PKK20981     470 LLPVVVVVFGVIIKRVIKYVMwalskagqn----------greerfnhGELVYHALQLLAYSVLAILIMRLKLFLTPHLC 539 rock pigeon
A6X919       482 LLPVVLVTVAAIVRKIFNDMRgvvakqrth----------trkqqfehGELVYHALQLLAYTALGVLIMRLKLFLTPHMC 551 house mouse
Q2PZI1       411 LLPVVLVVFVAIVRKIISDMWgvlakqqth----------vrkhqfdhGELVYHALQLLAYTALGILIMRLKLFLTPHMC 480 human
Feature 1                                                                                        
XP_006005635 506 IMASLVCSKQLYRWLSAkfrRQIIIFSILAVMAIHGSTNLQTQWSIIGEFSNLPQEELLEWIKANTKqdAVFAGSMPAMA 585 coelacanth
PWA33139     722 IMASLLCSRQLFGWIGErykHQAVVFTVLGMMAVQGVANLQAQWAIIGEFSNLPQEELLDWIQENTQpdSVFAGAMPTMA 801 western mosquit...
PKK20981     540 VMASLVCSKQLFGWLFCkiqPKTLVFAILALMAIEGSANLQTQWNIMGEFSNLPQEELLEWIKVNTRqdAVFAGAMPTMA 619 rock pigeon
A6X919       552 VMASLICSRQLFGWLFGkvhPGAVVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIRYSTKpdAVFAGAMPTMA 631 house mouse
Q2PZI1       481 VMASLICSRQLFGWLFCkvhPGAIVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIKYSTKpdAVFAGAMPTMA 560 human
Feature 1                                                                                        
XP_006005635 586 SVKLSTSRPIVNHPHYEDAHLRARTKqvYSMYSRKPAKEVKNALLKLGVDYFILEDSWCRRWSrPGCSMPEIWDVEDPKN 665 coelacanth
PWA33139     802 SVKLSAGRSIVNHPHYEDAGLRERTKlvYSMYSRMSGETVQRNLMKLGVNFFILEDSWCTRRTrPGCSMPEIWDVEDPDN 881 western mosquit...
PKK20981     620 SVKLSTLRPIVNHPHYEDAGLRARTKvvYSMYSRKPAKEVKRELIKLGVNYYILEESLCVNRKkPGCSMPEIWDVEDPAN 699 rock pigeon
A6X919       632 SVKLSALRPVVNHPHYEDAGLRARTKivYSMYSRKAPEDVKKELMKLKVNYYILEESWCIRRSkPGCSMPEIWDVEDPDN 711 house mouse
Q2PZI1       561 SVKLSALRPIVNHPHYEDAGLRARTKivYSMYSRKAAEEVKRELIKLKVNYYILEESWCVRRSkPGCSMPEIWDVEDPAN 640 human
Feature 1                               #      
XP_006005635 666 AGKTPLCILMAKDPRPHFITVFENDVYKVL 695 coelacanth
PWA33139     882 VGKTPFCTQMSNNPWPYFTTVFSNDVYKVL 911 western mosquitofish
PKK20981     700 SGKIPLCTLMSKVSRPYFFTVFENSNYRIL 729 rock pigeon
A6X919       712 AGKTPLCNILVKDSKPHFTTVFQNSVYKVL 741 house mouse
Q2PZI1       641 AGKTPLCNLLVKDSKPHFTTVFQNSVYKVL 670 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap