Conserved Protein Domain Family
HPP

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pfam04982: HPP 
HPP family
These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.
Statistics
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PSSM-Id: 461506
Aligned: 303 rows
Threshold Bit Score: 30.9454
Created: 28-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHA57794                86 IVASFGAAAVLEFYSIEAPLAQPRNAILGQVISALVGTIV-ATIFGGperllqstsddptlgfrslvYRwaGGALACAAA 164
Q0VKT9                  62 IFPSLGASAFLLFHLPLAEAASPRNVLCGHLIGALCGWAS-LWVCGLhdapaafi-----tgvewprVV--AAGLSLGMA 133 Alcan...
WP_012237270            88 VFPSLGPTAFLFFYTPTAASAAPRTTIVGHSIGIAVAYMS-LLITGLthagpata-----tgvtlprAI--AAALSLGLT 159 Soran...
Q1ASI0                  44 LFPSLGPTAFLFFETPLAEISTPRNTMIGHLVAAGSGYAS-LAAFGLldapgvlq-----agvgparIG--AAALSVALT 115 Rubro...
SIPI:L083_2766          36 LFPSLGPAVMLHLEKPRSPESSPRNTFIGHAVALLAGYAA-LRACGLtghpsalq-----egvttprIA--AAAGSLAVT 107
WP_015037189            59 MIAPLAATAMIICSTPVLPPAQPRGVMLGQVGSGVLGLAA-VALFGHs-------------------LW--VAAVAAGLS 116 Strep...
WP_015031806            65 LIPPLAASAALVHAAPTLPLAQPRSVVVGHLLGAAAGYAA-LAAAGSs-------------------AW--AAAVAAGAT 122 Strep...
BAJ30338                43 LIPPLAASAALVHGAPGLPISQPRNLVGGQLLSAVVGFGV-LAVAGSg-------------------PW--AAAVAGGLA 100
PRJNA261003:LJ00_27500  62 LIPPLAASAALVVGGAHFPLSQPRNVIGGHVMSAIVGVMVgMTALDA--------------------LW--AGAVAGALA 119
CCA55708                63 LIPPLAASMALVAGAPDLPLSQPRSVVGGQLLSALTGFAV-LTVASPg-------------------LW--AAAVAGGLA 120
EHA57794               165 TACMALTGTVHPPAGATALMAVVDDrivelgwwyiPI-------MLLGCALMLGVALLVNN-VQ---RRFP 224
Q0VKT9                 134 SALMILFRVAHPPAAATALIVSLGL----------MHelqqlpvLLSAVALLVAQAFVINR-LAg--IPYP 191 Alcanivorax bo...
WP_012237270           160 AGLMVLARAPHPPAGATTLIVSLGI----------LSrppmllvLLGGVVLLTLQAILINR-LAg--VDYP 217 Sorangium cell...
Q1ASI0                 116 SALLLLLRSPHPPAGATTLIVSLGL----------LStphelgmLALGAALLTAVGWAINR-AAgvpvpvw 175 Rubrobacter xy...
SIPI:L083_2766         108 TLVLLLLKASHPPAGATTLIVSLGL----------LHtpaqllvAAAAVVVVTAVDWAYNR-VTg--ARMP 165
WP_015037189           117 VGLMLLLRAVHAPAAATAVLAVLQD----------PDplrflvlLAVGSALLVLVGVIASR-LGv-iGKYP 175 Streptomyces v...
WP_015031806           123 LALTTLARTPHSAGCATAVVIVLQT----------PEaarfvplLFGSTVLLVLTGYAGSRiRRt-sPRYP 182 Streptomyces
BAJ30338               101 LVAMLLAHVPHSPAAATAVIVVLQA----------PRplvflplLALATAVLVLFGLLPHR-VGghpVRYP 160
PRJNA261003:LJ00_27500 120 LGMMKLLRMSHSPAAATAMIAVVPE----------IPrwefvvlVGTAAVILVVVGLAGNK-LNg--AKYP 177
CCA55708               121 LGVMMLARTPHSPAAATAVIVALQS----------PPfwsflglLALACLLLVAVGLGSAR-ATg--RTYP 178
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