Conserved Protein Domain Family
COG4253

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COG4253: COG4253 
Uncharacterized conserved protein, DUF2345 family [Function unknown]
Statistics
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PSSM-Id: 443395
Aligned: 114 rows
Threshold Bit Score: 255.356
Created: 9-Feb-2022
Updated: 24-Feb-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011286159  131 YADVAAWQWSDEVAGFLADARPRSYCVQYGESDYAFVSRLLAEEGLGWCVEEDKEAPAGHRLRLFADSQRFPEDIVSQSA 210 
NP_248953       1 MRQRDLKFTFVVGEGKLAFDVVEFELEEALCEPFRLNLKLASDKNAIDFKQVLDQPGTFTLWQDGRPARYVHGIVSHFTQ 80  
WP_011003821   78 VATDGGALHAINGIVSDVHSGAFDGTLASYRLTIIDAMSLMRRRRNMRIFVGKSVPDILGILLAEWQQRSAILGQAFRFQ 157 
YP_237148      14 RRLIKLTTVARDEQELLLESFSGTESLSELFSFELSMISRDAGLELKSQIGQPAQLAIELATGESRYINGYISAFSLEGS 93  
WP_013232298   86 GRLHHTNGLITDACAGHADGALRVYQLTMRDALSIMEGRVNTRIFRRLSVPSILEILLSEWRQRSSTLAAAFKFDLDGLD 165 
WP_119313266   66 KSLLGVAARLGVLDADGSQVVRCGVVSRAELLGSDGGFAKYGLTIEPPFALLRLRRTSRVFQDLSVPDIVKQILAEHQAN 145 
WP_027789809   89 INAIVHDVQAGQSDGELTVYQLRICDALSLMDRRINSRVFRSRNIIDILGTLLNEWRQRSPALARAFDFDLSGLRAERYP 168 
WP_027790133   86 RAINAIVSAVQIGRTDGELTVYQFTVTDAVNLLQKRTNSRIFRNVSVVDVLGVVLNEWRQRSVALAQAFEFDLSQLDRSR 165 
WP_088611369   87 INAIVENVQVGQSDGELCVYQLTVCDALSLMNKRTNSRVFRKQSVVDVLTVMFNEWRQRSPALARAFEFDLSFLNRDRYP 166 
WP_125975073   67 SLLGLPVVLSITDARGGVIERCGVVSQAQLLGSDGGFAKYKLTVEPPFALLRYRRTSRVFQDLSVPDLIKQVLAEHQDKN 146 
WP_011286159  211 NGGQGIRYHRADSQEDQDAILAFGERHRLASSVISAITYDYKAKKNVTLNITSAQPIGGKNAPVLESHDHPGLYAWANAA 290 
NP_248953      81 GSSGFRRTRYELLLEPQLARLELCCNWRIFQEKSVPEILQALLKEHRVLDYEQRIYHEHLPREYCVQAGDSDHYLHDRLA 160 
WP_011003821  158 LLLDRSGYPVRAQTLQLDESDSGFLDRLTRREGMFCFVVAGTPDGSDGDTPAQTLVFCDDPMKLPQAQAGAVPFHYGAAV 237 
YP_237148      94 DGGLARYSATLSPWLWMLSRRVDSRIFQEQTIEAVIRTVFAAYGALPDFEFQLSQPLKTHSYITQYRESDLTFVLRLLEH 173 
WP_013232298  166 DTRYPAREISHQFNESDAHFIRRLCRREGIAWYVASGQQADETAIATHADIPIHTLVFCDQPALLPRAAAGTVRYHRDGA 245 
WP_119313266  146 NPVFAQVQTLEFHTASANPRSYCLQYRESDFDFIVRLLHEEGYAWRFEHVDGEHPQVKLVVFDDAYSLPPAASERVRFHR 225 
WP_027789809  169 ARELTRQVNESDARFVRRLLRREGITVFAKAWAVGNARGTADERPIHTLVFCDDPLRLPESPAGTVRLHPRDSGTAQRDT 248 
WP_027790133  166 YPSRSFVRQVNESDARFISRIARRDGITMFVRAGRVSGETKDGDPPVHTLVFCDDPQKLNESAAGTVRVHPRDAGTEQRD 245 
WP_088611369  167 ARELTRQVNEPDAAFVRRLLRREGISVFVKAGPAKGGSTSEDDTPVHTLVCCDNPDSLQEAPAGTVRLHPRDAGTEERDT 246 
WP_125975073  147 PVFASVQTLDFKLSGNYPLQSYTTQKNESDYAFLCRIMQREGLSWRFAHLAGDSPQVQLVIFDDAYAIPEASDSHVRFHR 226 
WP_011286159  291 EAERYGRLAMEAREAGHRTWLGRSTVRSLRPGTVFDLIGLPIDPAKADAEHRYAATDITHLGINNLSGEAIATIAQRLGQ 370 
NP_248953     161 FEEGLVYYFRFDEHRHTLVCSDRLYVQERIAGGPVLFSAQPEGDNPQPVLHSFRYSENVRTARQTQRDYSFKRPTYDQEH 240 
WP_011003821  238 KARDSVTRWGEAHSLVSGTIRGTSPDYETGRVDRVDVDTLLDLGKAGNDLARLMTDAAVDRAHAGDSRADYERQGRLRMQ 317 
YP_237148     174 EGLFFYFDHNQEKHTLIILDHSRDLSPLPQQPTIRYHSASVTETADSITEWRSHRRLQSGRMSIQTFDYKQPRNSLPVGM 253 
WP_013232298  246 TEERDAISAWSRQRSLVPGSVWRRSWDYKAVRAEEASSHSIVDQGDAGYKLANILRDGLIEAPHAADSQNDHLRLADTRM 325 
WP_119313266  226 SDATEEEDGLTDWSAARQVVSGAVALASFDYQPVSTQHSGDQSRIQQGRSGDALQSTLQDYDPQSLYYASDAEQLSQYAQ 305 
WP_027789809  249 VTLFAHHQRLSPGKAGRLSWDYKKARMDDSAIATSIDQGDAGNDLARLLTDVAIDIPHVGDSWNDHDRITHDRILAHQFA 328 
WP_027790133  246 TITALTMRQQLISGESGRPSWDYRYARVDQSSASTKIDQGESGNDLAKLLTDIVIDVPHMADSWADHERMTEDRILAHEA 325 
WP_088611369  247 VTLFALHARLVPGAASRPSWDYKKARIDESTVAGEVDQGDAGNDLATLLTDVAIDVPHAGDSWDDHDRLTRSRMLAHQFE 326 
WP_125975073  227 ADSTETDDALTDWTTQRQLGSSSVALASFDYKAVKTNQSFDDSSVDQGEGGQQIQSSFEDYGSLSHYYANNSEDLSHYAQ 306 
WP_011286159  371 GAQKIDASDALATGDALTPISAPPSLPTELLKLAVERGYGNTFDAHAANVPWRPELEDRSGARINPRPTAPGPMSALVVG 450 
NP_248953     241 HLAGEALEHQGSSYERYDYPGRYKRSGAGRPFTESRLRGHRRDARVASVSGDDPRLIPGHAFALEGHPRADFNAWWRPVR 320 
WP_011003821  318 AHERRAAYVHAASDVRNLTPGSWFVLSGHPLVDKREPEQREFVVTRLRQRIANNFPKALNEQARALAEASGWHLEVRPGR 397 
YP_237148     254 PSLNEQGNVDSYEVYDVLDHYSHGTFKDGERLVRQRLEAIEVQGKTFTGNSNCRAMYPGHTFELTQHFDHDRGSAEDRSF 333 
WP_013232298  326 LAHEARSESFDASGTVRDLAVGHWFLLDGHPDMRGQKPAQREFLVTSLQQQAENNFPTVLQDAIRRLAPASPWKNLAHSA 405 
WP_119313266  306 RRQQAHDVQAKQFSGSGSVRSLLAGQWFRLDEHPLHEGDSSEQREFVVTGQTFRANNNLPGDLASSLRGLLGDSSTSNDS 385 
WP_027789809  329 AERYDGIGHVRDMPVGCWFTLTGDPELDMKPAEQRQFVVTSVRHDIRNNLPKDLAGRVIALYAASRNLAQAAPPSPAETS 408 
WP_027790133  326 QAVRYDGVSGIRDLAVGSWITIAGDDEWGTLPSDKQQFVITSLHHEVWNNLPKGLNERAQALFAASHTLQRPRTMTDGDP 405 
WP_088611369  327 AEQYDGASGIRDLAVGTWITLTGDPDLDMLSADKRQFVVTSIRHDVSNNLPKGLTERVQQLFAASKNLVSPSPAQLAPSS 406 
WP_125975073  307 LRQQSHDLVKKSFSGSGTLRSLQAGQWFRLEDHPAHEWDAAEKREFVVTELKFTANNNLPVDLTQQLLMIAPGLLVGSNP 386 
WP_011286159  451 PEGQTSPSGPDELWCDALGRVKIRFHWQQAETPDDRDSCWVRVLSRQAGPGMGWQWLPRIGQEVLVDFVGGDIDRPYLLG 530 
NP_248953     321 VVHRGTQYAGQEEESADAPLGVSYDLRAELVPEDVEWRPAPLPRPRIDGPQIATVVGPAGEEIHCDEWGRVKVQFPWDRE 400 
WP_011003821  398 DDAQIRYENTFTCVPRGAPLTPDYDPRIDLPRTDPMTAVVVGPNGQEVHCDELGRYKLQFVGLYAEDHAHAQGAGTSGTE 477 
YP_237148     334 LLITVKHEGSNNYLSDEGAGYTNEFVCIRHKIPYRHPITVPRPSINGPLSAIVVGPDGEEVFTDELARIQVRFHWQRGDS 413 
WP_013232298  406 ADLRYRNQLTCRRRTAPLAPHYDPRLHLPPVHPITALVVGPSKEEVYCDELGRIKVQLQGLHPEDHAHAQGAGASGHEQD 485 
WP_119313266  386 QNSSPFQTQITAQRRGIPLTPAYAHSTQAKPTSKGVQTATVVGPEGEEVHTDELGRIKVQFHWQRPDEHPGSGANLDDRS 465 
WP_027789809  409 EQADTRYENHFTCVRRGVPLTPSYDPTIDLPPAHLLTGTIVGTQGEEVFCDAAGRVRVRIHGFDPADHEHAQGAGTNGAA 488 
WP_027790133  406 SGQDTRYENTFSCVPRGTPLTPLYDPKTDLPPTPLITGRVVGVDGEEVSCDENGCVFVQILGQDSRDHAHAQGAGTNSNE 485 
WP_088611369  407 AESDTRYENTFTCVRRGVPITPAYDPRIDLPPVHLLTGVIVTRDGDEVVTDELGRVYVRIQGLDPADHSHAQGAGTNDNA 486 
WP_125975073  387 ADAAENAPYQADFTAQRRGQALTPRYDESSKPSSFGMQTATVVGPAGSEVHTDELGRIKIQFSWQRENEHPDFGANLDDK 466 
WP_011286159  531 ALYNGQGEGGISATPGGDSTKTQADNVFDSASDHRPSGQGNTAGGNSPAWHGAAETSHRHSAALTGFKSKEFGSASGYNQ 610 
NP_248953     401 GRHDEFSTCWIRVAQNWAGADWGHMAIPRIGQEVIVDYLDGDCDQPIVTGRTYRATNRPPYALPDHKILSTIKSKEYKGS 480 
WP_011003821  478 RDSAWVRAGNLWAGQRYGINLPLRAGMEVLVAFANGDPDRPYIATVLPGHNNMPTAFNDTGALPDNKHLSGIKTKEVDGS 557 
YP_237148     414 LPQGTTWLRVAMPSAGSGFGHQFMPRIGQEVLVTFLAGDIDRPLVTSVLYNNINLPPRFSKASGLPGNRTLSGIRTQEHK 493 
WP_013232298  486 SAFVRVSSAWAGAGYGHDAVPRVGMEVLIDFLGGDPDKMFVAGVLHNGINLPARFSHSGSLPGNRFLSGIKTKEIGGARY 565 
WP_119313266  466 SCWLRVAMPSAGAGWGHQFIPRIGQEVLVDFIEGDIDRPVIVGVLYNGSHATPAFSGAGALPANKTLSGIKSKEHQGGQY 545 
WP_027789809  489 GDSAPIRVGASLAGGNFGTLFLPRVGMEVLLGCLSGDPDRLVIIGVLSNGANPPATFTHTGALPGNRYVSGIKTKEIKGA 568 
WP_027790133  486 SDSAPIRVASSLAGPNFGETFLPRVGTEVLLGSLGGDPDRLVIIGVLANGANMPASFTHTGSLPGNRFLSGIKTKEIKGQ 565 
WP_088611369  487 GDSAPIRVASSLAGTQFGASFLPRIGMEVLLGAIGGDPDRLVIIAVLGNGANPPAAFTHTGSLPGNRYVSGIKTKEIKGQ 566 
WP_125975073  467 SSCWVRVAYPSAGASWGHQFIPRIGQEVLVGYLDNDIDRPIVTGVVYNGSHGVPDFSGAGSLPANKTLSGIKTKEHQGGQ 546 
WP_011286159  611 LLLDDSDQQQRLQLKSTQHHSELNLGHLIHQADNYRGSFRGTGTELRTDAWGALRGGQGLVMTTWAHPSAGa--STAQPA 688 
NP_248953     481 RANELRIDDTTAQISAALMSDHGASALHLGYLTHPRPEGGKPRGEGFELRTDEHGAVRAAKGLLLSTEEQL---RAGAGH 557 
WP_011003821  558 GFNQVAFDDTPGEISSQLASTHAASQLSLGYLTHPRDQGKAEPRGEGAAITTQAMASMHGNQGMLLSTERR---SQAGNQ 634 
YP_237148     494 GSGFNELLFDDTPGSLRARMGTTHQATALNLGKLTDPRTDGTAQPRGNGAELRTDAAIALRAAQGMLLTTYartDAKGSQ 573 
WP_013232298  566 NQLRLDDSPGQISTQLASEHQHSQLNLGYLTEPRHGGRGEDRGEGLEARTDGHGVMRAAKGVMITAQSQDR----GRGRM 641 
WP_119313266  546 NELLFDDTPGEVRAKLSSEAGKTQLNQGYLTHPRSNGKAQPRGEGFELRTDQHGAIRAGHGLLISTEAQNG----ASGKQ 621 
WP_027789809  569 RYNQLRLDDTPSQISAQLASEHAHTQLNLGYLTQPRKDGHGADRGEGAELRTDAAAALRAAQGILFSTYARt--CATGGQ 646 
WP_027790133  566 RYNQLRLDDTPQQISAQLASEHAHSQLNLGYLTQPRDNGQGADRGQGAELRTDAAAALRAAQGMLLTTYARt--QASGGQ 643 
WP_088611369  567 RYNQLRLDDTPGEISSQLASEHAHSQLNLGFLTQPRQDGQGKGRGEGAELRTDAAAALRAAQGILLTTYARs--QASGGQ 644 
WP_125975073  547 YNELLFDDTPQEVRAKLSSETGKTQLNQGFLTHPRKDGKAEPRGSGFELRTDLAGAIRGAQGLLLTAHDQP---GAKGAQ 623 
WP_011286159  689 GDMAPAMALLRQADTLARTLNQAAATHQTVQLSSAigtqgqdq-skidpeaaPLKALHKVSSGMVDakdqsaakqdaqqk 767 
NP_248953     558 LDRGVVVQVLEAALELARELGDYAGEHQGVGHDAA-----------------PQQTLQEAVRDLGHga------------ 608 
WP_011003821  635 MDRDGLLGLAQAFASVAAEFGKMAATHHAGTYDPA-----------------PLKQLIRQLQDWEHgtn----------- 686 
YP_237148     574 LDREELLKLLAECGELFKSLGETAAARGSQAVDVK-----------------GMEALRQSLDQWP--------------- 621 
WP_013232298  642 LERAALLETLDNLQELAQRLSHDAARHHAEATDVA-----------------QLERIRAQLRAWDAgd------------ 692 
WP_119313266  622 LAREHAQSQLDAALSLSQSLGDTAAAQLADSMETGpdainpdngkdgnkdsgHLQHHAAALKAWEAgsntd--------- 692 
WP_027789809  647 LDRDELIQLLDQCMMLFNSLGDYAGQHGGRAADTA-----------------GQEKIVDAFRHWKPdl------------ 697 
WP_027790133  644 LDRDELVELLGECAELFKALGDYAGQHGGTATDAT-----------------GQQAVVTAFKGWTPgghas--------- 697 
WP_088611369  645 LDRDELLQLLGECTELFKSLGDYAGEHGGQATDTA-----------------GQQAVAAAFKSWTPaggas--------- 698 
WP_125975073  624 LERDELISQLEQALAIAQQLAKQAETHEADNTDTK-----------------QEEQLLGDLKKWHAgs------------ 674 
WP_011286159  768 itnasPDKRPHLTDPAIVQTGKAGIGHVAGQNLQYTNGETLVLASGEDTNLAIAGKARIHSGQAIGLLAGaiapgdgNTG 847 
NP_248953     609 ---ndESGKSNGGKPAIALSGPAGIAAATPASLTLAAGEHVDSVARQNQQVTAGQKVVINAGSDIGLFAQ-------GGE 678 
WP_011003821  687 ---taPQGAGQGGTPLIALSSPAGIVAGSADNIALAAQTSVDVMSGDNTQISAGKDALIYATNEVSIFAV-------EGG 756 
YP_237148     622 -----APDNNGLGDPVLAMTAVAGIASATPRSQVHYAGENHDTTAQDNLQLTSGAAMHLQAGKGLSAFAQ-------DAG 689 
WP_013232298  693 ----vANGAVRAETPMVAVDAPAGVSITSQDTMVLGAAQHIDLVSRANTQLSAGRRLLMRAGEMLSAFAA--------KH 760 
WP_119313266  693 -kdgkTAKDQAGQQPLLILSAPAGIASLTEQSHTISAGTNLNLIAQRDSNHTTGRRWLHNVGQHISLFVAgv---kdKVA 768 
WP_027789809  698 ----aDAGSAGDTSALMAFGAQAGSLHVTPRTHVMYAGENIDQIAQRHVQVASGERINLHGGHGVAMFAH-------SGG 766 
WP_027790133  698 gddraSNAGAGDSQALMAFGAKAGALNITPKTYVTYAGENIDQIARQNLQFAGGQRVITTAGQGIHLFGR-------GEG 770 
WP_088611369  699 -ntgaGAGTGSGSQALMAFGAQAGSVAITPKTHVTYAGENIDQVAQQHVQVTSGQRINLHGGRGVAMFAH-------SDG 770 
WP_125975073  675 ---ntDKEGQGGGKGIVAMTAPAGIAISSQSAISIVSGANHDQIAAKDSNHSIGQKLRFRIGESLSIFVQ-------QMG 744 
WP_011286159  848 IKLIAAKDDIDLQAQSDEMKFLAKKDIKLVSA------TQHIDFAAAKKIHLAvQGGASITIDGG-ITVQCPGTITVHAS 920 
NP_248953     679 LRQITHQGPMLLQAQKNDIRLEAKQSVEVSAS------QQHVLVTAKEHITLM-CGGAYLTLKGGnIELGMPGNFVVKAA 751 
WP_011003821  757 VRVVTAKGDVVVESHTGNIALNGAKRITLNAG-------EEIVLNAP-RVRTV-TQGAQTTWGGGeIVEEASGGYTIKSA 827 
YP_237148     690 ISAIANRGKVLVQAQEDDIALNAQKNLHVSAV------EGEVVITAPTIRLVA-DDGSYIKI-GGgVEIGSQGKVTVHAS 761 
WP_013232298  761 MKLISGKGSIKIQAHEEHIDLSAARRILLEASeeiilqAPKISIRSRETTEVA-GGGSFSRWNASaIEHGTSGEWRQQAA 839 
WP_119313266  769 LKLIAAKGKVQVQAQSDALELTADKELTITSA------KGAVTLAAKEEILLT-SGGGYIRLKGGnIEIHCPGTVSVKGA 841 
WP_027789809  767 VSAIANRGKVTIQSQDDDTQVDSAKNIQLTAA------GGKLAGMANDQVVFVtSGGAYLKLNGGdIELGCPGTFTVKSA 840 
WP_027790133  771 VRAIAGEGPVVLQAQQDTLAATAQKGIQIMSV------GDEVLISGKSIRLVA-EDGSYVKI-GGgVEVGSDGAFTAHTA 842 
WP_088611369  771 VSAIANQGKVTLQSQNDDTQIDSAKNIQFTAA------DGKITGMANDQVVFTtSGGAYLKLHGSdIELGCPGKFTVKSA 844 
WP_125975073  745 MKLIAAAGKIHIQAQSDQMEIGASKRLHLYSL-------EEILLEAP-KITLR-TQGTDIALGAGnIITQASGSHTQKAS 815 
WP_011286159  921 KKSFTGPGQGSYALPQFP---------QTALpetvaafSMLLTHIp-----GPSGK-PLSDLDWQIVrasdedgarMADK 985 
NP_248953     752 KHSHVGAASLEAELPQFE---------VGET-------QRRFVLK------QLDGQtAMPNVPYTIT---------MANG 800 
WP_011003821  828 NFQQIGGGGAPAASN-LP---------ANDRh-----fDRHLRLTd-----QLTGE-PIANRRYRAT---------LADG 877 
YP_237148     762 EHDWIGPKTDSAAIPSFG---------RDPA-------AQQVTFHypg-hsEQSPR-AAADHSYEIK---------LEDG 814 
WP_013232298  840 MHHVLGPANCPPP--DIPppptyeelqQSS--------SLMVRLRs----hARDGR-LLAHQPYTLFk----------QG 894 
WP_119313266  842 SHALSGPASLNYRMPTFG---------KVY--------SGRFQLQn-----QKTGE-PLIGRAYSIK---------QAGG 889 
WP_027789809  841 GHAWGGPASMSTDMPTFD---------HAPL-------GRVPKLVr-----ATDGD-AVAGFDGHMQ---------RASE 889 
WP_027790133  843 GHDFVGPNTDHVAPPAFN---------RGGA-------DQKFRLRypgtdgDDGTH-PVPNRPYKIT---------LRNG 896 
WP_088611369  845 GHSWQGPASMSTDMPKFD---------HAAL-------GRVPKLVr-----ASDGN-PIEGYVGEVH---------KASG 893 
WP_125975073  816 QHNMEGPGNGSPQLPSMP---------KSENk-----tDEQFSIV------SRSGK-AITEVKHEIH---------SDAG 865 
WP_011286159  986 S-LLK-GVSNGEGRLALSQ-SEq-------DLLKD 1010
NP_248953     801 E-VIE-GVTDAEGATQLLQ-KDamni-akvDMKHT 831 
WP_011003821  878 Q-VVE-GVSDAQGYAKHLK-SSitfahyslEILD- 908 
YP_237148     815 S-LVK-GMTNADGLTERVE-REmmhq-aqvSALRS 845 
WP_013232298  895 EqIAV-GVTDAAGQLRIKDhQPgdds-ysvRLSNG 927 
WP_119313266  890 R-TIN-GYTDQEGWTMTAM-SRqpeg-mtlQVLEK 920 
WP_027789809  890 A-LSN-LTTDAAGELPAVH-GHqfet-lsvQFIKK 920 
WP_027790133  897 Q-VIN-GVSDAHGLTELAS-SDamhi-ahiQVFDV 927 
WP_088611369  894 E-IVN-GQTDSAGTMAPID-HNqfeq-vvvKFFKK 924 
WP_125975073  866 K-LLEsGSTDAKGATSRLK-GKaies-inlKLTRK 897 
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