Conserved Protein Domain Family
Hydrophob_seed

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pfam14547: Hydrophob_seed 
Hydrophobic seed protein
This domain has a four-helix bundle structure. It contains four disulfide bonds, of which three function to keep the C- and N-terminal parts of the molecule in place.
Statistics
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PSSM-Id: 434033
Aligned: 12 rows
Threshold Bit Score: 61.307
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFH46517     157 TCPIDALKLGACVDVLgGLIHIGLGKSyAKAKCCPLLEGLASVDAAVCLCTTIRAKLLN-IDLIIPI--ALELLVD-CGK 232
XP_002520567 215 TCPIDTLKLGACVDVLgGLIHIGIGSS-AKDACCPVLQGLVDLDAALCLCTTIKAKLLN-LNIIIPI--ALEVLVD-CGK 289
XP_013688479 180 TCPIDTLKLGACVDLLgGLVKIGLGDP-AANKCCPLLKGLVEVEAAACLCTTLKLKALN-LKLYVPV--ALQLLLT-CGK 254
XP_002437917 237 TCPIDTLKLNACVDVLsGLIHLVIGQE-ARSKCCPLVQGIADLDAALCLCTTIRLRLLN-INIYLPI--ALNLLIT-CGK 311
EFH46081       7 TTIMS--DLGICVNVL-GLINLTTS---NVAQCCSILSGLNAPLVSVCACEALRLNILNlLGITINLnlRLNGLLGlC-R 79 
XP_002869821  36 VCPR---DIQACVNVL--RTSVILNAQ-TVSRCCTLVAGLDASVASVCICNAVRISLLNiLTITL----RLNQVLGiC-R 104
EFH46079      31 VCPRDSINFISCSNVF-RLSLILINKQ-TVLPCCTLVAGLDAAAASACICNAVRITIFNfLTINL----RVNQVLRlC-R 103
EES12958      45 sCPWDAVKFGACVGVL-GAAGLQAGAQ-LGSKCCDVVQGLAAAEAAACFCTTVKETVLG-IPTEWDV--GVGVLASaCKT 119
EFH44026      36 TCPRNPLQLGVCANVL-GLANVTAGDP-RARQCCTAINGLADVQVADCLCFIFRP-----LPLVFAIdeAVREIFFaC-N 107
NP_001078427 577 TCPRNANQIRTCSNVL-RFFGNFLDFR-LAQPCCTLIRNLSDAEAAACLCDLVRARRSTlSP-------NIIILCRaCGR 647
NP_193978    296 iCSKNDTELKICAGIL-AISDGLLTTG-RAEPCCSIVRNVSDLDAVTCFCKSVGARRFSlSP-------NFGIFFKvCGR 366
EFH44025      85 RCPRNGLPLQICSTIL-SIFDGFLGFG-RAQPCCSLIRNLSDADALACLCESVRAPSGSlPP-------NIINLYRtCGR 155
EFH46517     233 TP-PRGFKCP 241
XP_002520567 290 NP-PPGFQCP 298
XP_013688479 255 NP-PPGYTCS 263
XP_002437917 312 HP-PSGFQCP 320
EFH46081      80 LPiQPGYNCL 89 
XP_002869821 105 ITpPAGFTCA 114
EFH46079     104 ILpPAGFRCA 113
EES12958     120 EL-PNGFKCl 128
EFH44026     108 RVfPIGFQCP 117
NP_001078427 648 RI-PRGFTCP 656
NP_193978    367 RI-PQGFSCP 375
EFH44025     156 SI-PPGFTCP 164
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