1BT6


Conserved Protein Domain Family
S-100A10
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cd05024: S-100A10 
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S-100A10: A subgroup of the S-100A10 domain found in proteins similar to S100A10. S100A10 is a member of the S100 family of EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this S-100A10 group belongs, contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are expressed exclusively in vertebrates, and are implicated in intracellular and extracellular regulatory activities. A unique feature of S100A10 is that it contains mutation in both of the calcium binding sites, making it calcium insensitive. S100A10 has been detected in brain, heart, gastrointestinal tract, kidney, liver, lung, spleen, testes, epidermis, aorta, and thymus. Structural data supports the homo- and hetero-dimeric as well as hetero-tetrameric nature of the protein. S100A10 has multiple binding partners in its calcium free state and is therefore involved in many diverse biological functions.
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Statistics
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PSSM-Id: 240151
Aligned: 5 rows
Threshold Bit Score: 160.393
Created: 29-Dec-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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annexin 2dimerization
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:annexin 2 binding sites
Evidence:
  • Structure:1BT6_A, human S100A10 homodimer bound with 2 annexin II N-terminal peptides, contacts at 3.5.
  • Comment:each site is formed by the C-terminal helix and the L2 linker region of one monomer and the N-terminal helix of the other monomer
  • Citation:PMID 9886297
  • Comment:S100A10 has lost its calcium binding properties
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   #  #                            #  ##                                    
1BT6_A        2 SQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIA 81  human
P27003        3 SQMEHAMETLMFTFHKYAGDKNYLSKEDLRALMEKEFPGFLENQRDPMALDKIMKDLDQCRDGKVGFQSFFSLVAGLTIA 82  chicken
P27004        5 SELEHSMEKMLLTFHKFAGEKNYMNRDDLQKLLDSEFSEFLKNQNDPMTVDKIMKDLDDCRKGQVNFRSYCSLIAGLLIA 84  African clawed frog
AAH78507      5 SELEHSMEKMLLTFHKFAGEKNYMNRDDLQKLLDSEFSEFLKNQNDPLAVDKIMKDLDDCRDGRVSFHSFFSLIAGLLCA 84  African clawed frog
NP_001011436  5 SELEHSMEKLMLTFHKFAGEKNYLNRDDLQKLMECEFSEFLKNQNDPMAVDKIIKDLDDYRDGKVTFHSFFSLIAGLLCA 84  western clawed frog

Feature 1       #  #    #  
1BT6_A       82 CNDYFVVHMKQ 92  human
P27003       83 CNDYFVVHMKQ 93  chicken
P27004       85 CNEYYVKHMKK 95  African clawed frog
AAH78507     85 CDDYYVKHMKV 95  African clawed frog
NP_001011436 85 CNEYYVKYMKH 95  western clawed frog

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