Conserved Protein Domain Family
BicD

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pfam09730: BicD 
Microtubule-associated protein Bicaudal-D
BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta pfam05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells.
Statistics
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PSSM-Id: 462863
Aligned: 6 rows
Threshold Bit Score: 935.432
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q921C5        83 GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKE----------- 151 house mouse
XP_006507087  74 GQSFSIHRKVAEDGETREETLLQESASKEAYYLNKILEMQNELKQSRAVVTNVQAENERLSAVVQELKE----------- 142
AAI34922      81 ADSVSSHKRAAADGESREERLLQESANKEAEMDIRMDELQAELKQARVMLNNTSAENERLVSLSTQMKK----------- 149
CAG03949      57 aDSVSSQKRAAADGECREECLLQETASKEAAMATRIEEVQAELKQTRLALSNTHAEIDRLAVFSTQLKK----------- 125 spotted green p...
CAG11345       4 GQAYTNHRKVAADGESREESLIQESACKEAYYEQRVLELQNDLRQARNLVANAQSENDRQNALSQEIKDtgscandtnag 83  spotted green p...
CAG06883      83 GQAYSTHRKVAADGESREESLILESASKEALYQQKLLELQNELRQAKASFSSVQAENERLASIVLDMREvpiyf------ 156 spotted green p...
Q921C5       152 ------INQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQ 225 house mouse
XP_006507087 143 ------NNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQ 216
AAI34922     150 ------ECECLEVEKTRMREEMKEYKTREAQQLQDNSELEEENISLQKQVSVLKENQVEFESVKLELTHKDEELELMRAQ 223
CAG03949     126 ------ECECLEAEKGHMRDEMKEYKVRELRLLQDNAELEEENTSLQKQESVLKENQVEFEGIKLELTQKNEEQEELRGQ 199 spotted green p...
CAG11345      84 perrqdHSQMVELQRNQLRDDIKEYKLLEARLLQDYTELEEENITLQKQVSVLKQSQVEFEGLKHEIRRLEEDTQFLNSQ 163 spotted green p...
CAG06883     157 --fktqNSELAELQRGQLRDDIREYKVREARLLQDCSELEEENISLQKQVSVLRQNQVEFEGLKHEIRRFEEDSQCLQSQ 234 spotted green p...
Q921C5       226 LEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDsfytSHLQVSLDGLKFSDDt-vTAEPNNDaEALvNG 304 house mouse
XP_006507087 217 LEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYINLSD----SHISISVDGLKFAED---GSEPNND-DKM-NG 287
AAI34922     224 LEEAGRLREIAEHQLDEALEALKEEREQKNSLRREVAA-LTLNPfdsiSHLEIQL---NDSRDgekDREEGEEdEEM-DS 298
CAG03949     200 LDEAARLREIAEKQLDEALEALKEEREQKNSLRRELSA-LTLNPfdsvGNLELHLDQLDDSREegrGGEREGEgEDQ-DS 277 spotted green p...
CAG11345     164 LEDAIRLKEIAERQLGEALETIKTERELKASLRKELSHYMNIGDalynSPLSISLDGLKFSEEa--ATEPNND-EAL-LG 239 spotted green p...
CAG06883     235 LEEAVRLREIAERQLTEALETIKTEREQKATLRKELSHYMTIGGsvygGSFSISIDNLKLHEDpsaNTEPDND-DLI-RG 312 spotted green p...
Q921C5       305 FEHSg-------------LVKSSL-DNKTSTPRKDGLA--PPspslVSDLLSELHISEIQKLKQQLVQMEREKVGLLATL 368 house mouse
XP_006507087 288 HIHGp-------------LGKLNG-DYRTPTTRKGESL--HP----VSDLFSELNISEIQKLKQQLIQVEREKAILLANL 347
AAI34922     299 GYNNsk-----------gME-----RNRCSTPRNSEVFlrPQapglVSDLLSELHLSDSQKLKQQLIQVEREKATLSSTV 362
CAG03949     278 GFNNgpgsapssashlggSKNNGL-LHRFSTPRSSDVFlrAPasglVSDLLSELQFSDSQKLKQQLLQTEREKTSLVDKV 356 spotted green p...
CAG11345     240 YENGft-----------kLANAINyDNCVSTP-KKELF--PPapslVDDLLSELNISEIQKLKQQLMQMEREKVNLLTTL 305 spotted green p...
CAG06883     313 FENGl-------------LKVSEG-----GEDKKGEAF--KPapslVDDLLSELNICEIQKLKQQLMQVEREKVVLISSL 372 spotted green p...
Q921C5       369 QDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDSHED---GDYYEVDINGPEILACKYHVAV 445 house mouse
XP_006507087 348 QESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQNSKEIKAELDCEKGRNSAEE---AHDYEVDINGLEILECKYRVAV 424
AAI34922     363 HELQQQLVQSKDAFSEQQEKMDQLTQHLENLQNMITKRSAEDGNRMSSSPTSQDPengINYYEVDTKSTEVLECRMQAAN 442
CAG03949     357 EELQMQLVMSKQALSQQEDKVGSLTQQLEAVKG-----GQQDADDSGDQKSENAT----LEYEVDTKSKEVLEARMRSAS 427 spotted green p...
CAG11345     306 QDSQKQLEQANGALSEHQDKVNRLTENLNAIRKLQASKERQSALDNEKERDSHED---GDYYEVDINGPEILECKYKVAV 382 spotted green p...
CAG06883     373 QESQKQLEQAYGTVSEQKETVNRLTENLSAMRKLQASKERQSALDSEKDRDSHDD---GDYYELDINGPEILQCKYTVAM 449 spotted green p...
Q921C5       446 AEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVA 525 house mouse
XP_006507087 425 TEVIDLKAEIKALKEKYNKSVENYTEEKTKYESKIQMYDEQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNTLNTA 504
AAI34922     443 EELARLHVKLKDAEKRYKTLEERCKLEKQRWRGEAQDLADQIRQCITASRQDQERIGQLEREIGATRKVATDSEGHLSAA 522
CAG03949     428 EELLKLRDELTQAGARYNTLEQRYKQEKDRWRAEAQDLADKIRQCIKSSKQDQERIGELEKEIGATRKVASDSEGHLSVA 507 spotted green p...
CAG11345     383 SEAGELKEELKTLKAEYQACQSRYEDDRARLENDVTTLGEKLASLEKTSHVDREEKNKLETELRKLRDVAGESQGSLSVA 462 spotted green p...
CAG06883     450 SEAGELRQELKTLRAKYEKCRNQYEEEQTRLERDVQELRSKLQTLERISHLDKAEMARLEKELRLVSEAAGESLGSLNVA 529 spotted green p...
Q921C5       526 QDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAG-R--TSPEGRGRRSPVLLPKGL-------LATEVGRAD 595 house mouse
XP_006507087 505 QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSgSlkGPDDPRGLLSPRLSRRGVsspvesrTSSEPVSKE 584
AAI34922     523 QEELLAFSEDLANLYHHVCVSNNLTPSRVTLDYYREGAQAVRtQ--NHQLPHHYRGSLRRQRRS---------GEVLDPN 591
CAG03949     508 QEELLAFSEELSILYHHICVCNNLTPKRVTLDYYRDGARASArK--SHVYPQHLRKPRADDVFAskasvlqFMGEMDTAG 585 spotted green p...
CAG11345     463 QDELVTFSEELATLYNHVCMCNNETPNRVMLDFYKEGKGGR-----SSPEGRGRRSPILLTKGL--------FPEPGKTD 529 spotted green p...
CAG06883     530 QDELISFSEELANLYNHVCMCNNETPNRVMLDYYKQGKAIIK----KGQEGKEPPSSILLTNGM-------IETEV---- 594 spotted green p...
Q921C5       596 GGtgDNSPSPSSSLP-SPL------------SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA----SQELG 658 house mouse
XP_006507087 585 NTetSKEPSPTKTPTiSPVitappsspvldtSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA----ARELA 660
AAI34922     592 STgsGDAPSNCGSCPgSPT------------LDFR-DPTNVRNLVAVIRCQIKHLQVAVD----LCRQRSLlsspAAGGS 654
CAG03949     586 TG--SESP----NCPgSPI------------LDFR-DPSNVRNLVAVIRCQIKHLRVAVD----LCRQRGAvpysGLSSS 642 spotted green p...
CAG11345     530 LS--DRAPSPVSSLP-SPV------------SDHRREPMNIYNLVAIIRDQIKHLQLAVDRTTELSRQRVA----SLELG 590 spotted green p...
CAG06883     595 ----KNSPSGNSSVTlAPT------------SDHRPEPMNIYNLVAIIRDQIRHLQQAVDRTTELSRQRLA----NLELS 654 spotted green p...
Q921C5       659 PAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAAT 738 house mouse
XP_006507087 661 PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAAT 740
AAI34922     655 TESDRDTEALIEEVLKLKSLLSTKREQIATLRTVLKANKQTAELALTNLKTKYETEKSMVTETMMKLRNELKALKEDAAT 734
CAG03949     643 EESERDAESLLEEVLKLKSLLSTKREQIATLRTVLKANKQTAELALSNLKTKYETEKSIVSETMMKLRNELKALKEDAAT 722 spotted green p...
CAG11345     591 TVADKDKEACMEEILKLKSLLSTKREQIATLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKGLKEDAAT 670 spotted green p...
CAG06883     655 SVADKDKEACMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKSKYDSEKAMVKETMMKLRNELKALKEDAAT 734 spotted green p...
Q921C5       739 FSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLEL 797 house mouse
XP_006507087 741 FSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEF 799
AAI34922     735 FSSLRVMFASRCDQYVTQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEA 793
CAG03949     723 FSSLRVMFASRCDQYVTQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEa 781 spotted green pufferfish
CAG11345     671 FSSLRAMFATRCDEYVMQLEEMQRQLTAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEF 729 spotted green pufferfish
CAG06883     735 FSSLRAMFATRCDEYVTQLDDMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEF 793 spotted green pufferfish
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