4NV0


Conserved Protein Domain Family
UMPH-1

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pfam05822: UMPH-1 
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Pyrimidine 5'-nucleotidase (UMPH-1)
This family consists of several eukaryotic pyrimidine 5'-nucleotidase proteins. P5'N-1, also known as uridine monophosphate hydrolase-1 (UMPH-1), is a member of a large functional group of enzymes, characterized by the ability to dephosphorylate nucleic acids. P5'N-1 catalyzes the dephosphorylation of pyrimidine nucleoside monophosphates to the corresponding nucleosides. Deficiencies in this proteins function can lead to several different disorders in humans.
Statistics
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PSSM-Id: 310424
Aligned: 10 rows
Threshold Bit Score: 374.39
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NV0_A        58 YTITKQRTeDGGAVPSSFGIFNAC-QSLPENFKAETDKLYHKYRPIEIDPHMPIAEKVQYMIEWWTKSGELTSGFPFDQS 136
XP_002026381  58 YTITKQRTeDGSVVPSSFGIFNAC-QSLPDSFKTESDKLYHKYRPIEIDPHMPIPEKVQYMVEWWTKSGALATGFPFDQS 136
Q17PQ5        51 YTITKQRLeNGEKILTSFGMFNEC-KSLPEYVLEETKRLFHKYRPIEIDPHMPLDEKVVYMIEWWSKTGDLLKGFPLPQE 129 yellow fever mo...
Q7QE29        46 YTITKQRLaNGEKVLTSFGMFNEC-KSIPQDVILEQRNLYHKYRPIEIDPHMAHEEKVVYMIEWWAKTGDLLRGFKLPQE 124 Anopheles gambi...
Q5ZID6        86 MTLSRFSY-NGKRCPTCHNIIDNS-KLITEECRKKLLQLKETYYAIEIDPALTIEEKYPYMVEWYNKSHALLIEQGLQKD 163 chicken
CAF93645      77 MTLSKFAV-NGKRCPTCHNIIDNC-KLVTEECRQKLLQLKNKYYPIEIDPHLTMEEKYPFMVEWYYNSHTLLVEQRLEKE 154
Q3UFY7        44 MTLSRFAY-NGQRCPSSHNILDNS-KIISEDCRKELTELFHHYYPIEIDPHRTIKEKLPHMVQWWSKAHSLLCQQRIQKV 121 house mouse
Q5ZKF6        41 MTLSRFGC-NGRRCPTSHNILDNS-HVISEDGKKKLKDLLHHYYPIEIDPNRTLEEKRPLMVEWWTRAHELLSQQKIQKG 118 chicken
XP_002264488  85 ATLTKYWV-NGCRGQSSHGLLQQG----NPEYDVKRRELYDYYHPLEISPSIPIEEKAKLMEEWWGKTHALLIEGGLTYD 159
Q95ZJ9        47 FTLSRFADkSGNRCSSCYCVFDSAvGTNNPEWCRKFVGLYHKYGPIEHDHSLSIEEKVPFMEAWWQQSHGLIIQGGFKKQ 126 Caenorhabditis ...
4NV0_A       137 EIDQIASKYTHALRDRTHEFFADLQRLGIPTLVFSAGLGNSVVSVLRQA-NVLHPNVKVVSNFLQF-RDGLLDGFQQPMI 214
XP_002026381 137 EIDQIASKYKNALRDRTHEFFADLQRLGIPTLVFSAGLGNSVVSLLRQA-NVMHPNVKVVSNFLQF-RNGLLDGFQQPMI 214
Q17PQ5       130 EIAEVAKRFKDGLRDGTHQMFFDLNQLEVPCLVFSAGLGDSVVSVLRQA-NVMYPNVKVISNFLQYsSDGTLNGLQDKMI 208 yellow fever mo...
Q7QE29       125 DIDEVAKRYKDGLRDGTHDMFKELHELNVPCLVFSAGLGNCVSSVLKHA-NVMYPNVKLVSNFLQFsENGMLNGLQNPMI 203 Anopheles gambi...
Q5ZID6       164 KLAEVVRESDVMLKEGYENFFDKLSEHNIPVFIFSAGIGDILEEVIHQA-GVYHSNVKVVSNFMDFdENGILKGFKGELI 242 chicken
CAF93645     155 KLAEVVRESDAALRDGYEQFFDRLQKYNVPVFIFSAGLGDVLEEIIHQA-GVYHSNIKVVSNFMDFdDNGVIRGFKGELI 233
Q3UFY7       122 QIAQVVGESTAMLREGYKTFFDTLYQNNIPLFIFSAGIGDILEEIIRQM-KVFHPNIHIVSNYMDFsEDGFLKGFKGQLI 200 house mouse
Q5ZKF6       119 DIAQIVRESDVMLRDGFNELFDQLHKYSVPMFIFSAGVGDVLEEIIRQA-NVFYPNVNVVSNYMDFdDSGVLKCFKSPLI 197 chicken
XP_002264488 160 AITKSVANSMITFREGVVELFEFLEARDIPVLIFSAGLADVIEEVLRQKlHRSFKNIKIVSNRMIFdGDGHLVSFKGKTI 239
Q95ZJ9       127 AIDDYVAHCNIQLRDNADIMMKKMTNHAVPFIIFSAGIGTIIEMYLRHKfGRVESNTHVVSNMMGFdDDGYVNSFSDPLI 206 Caenorhabditis ...
4NV0_A       215 HTFNKNETVLnE-TSEYYDLV-------------HTRDHIIVMGDSIGDADMASGVPASSHIMKIGFLFDHVEANMKKYM 280
XP_002026381 215 HTFNKNETVL-D-GSEYYNLV-------------HTRDHIIVMGDSLGDADMASGVPASSHIIKIGFLFEHVEANMDKYM 279
Q17PQ5       209 HTFNKNETAL-K-GTEYYDLV-------------HDRDHVIVMGDSLGDAGMADGIPSSSYVLKIGFLFDHPEQNLPRYM 273 yellow fever mo...
Q7QE29       204 HTFNKNETVL-D-GTEYYDIV-------------HSRDHVIVMGDSLGDAGMASGVPSSSHILKIGFLFDHPELNLPRYM 268 Anopheles gambi...
Q5ZID6       243 HVYNKHDGAL-K-NTEYFKQL-------------KDNSNIILLGDSQGDLSMADGVANVEHILKIGYLNDKVDELLEKYM 307 chicken
CAF93645     234 HVYNKHDGAL-R-NTEYFKQL-------------KEYSNIILMGDSLGDLSMADGAPCVENILRIGFLNDKVEERLDKYL 298
Q3UFY7       201 HTYNKNSSVC-E-NSSYFQQL-------------QNKTNIILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYM 265 house mouse
Q5ZKF6       198 HTYNKNNSVL-Q-GTAYFQQL-------------STRTSIILLGDSMGDLTMADGVPSVENILKIGFLNDKVEEQRGRYL 262 chicken
XP_002264488 240 HVLNKNEHAL-DmAGPLHDELgdsdgpnedsasvKKRTNVLLLGDHIGDLGMSDGL-DYETRISVGFLNDNVEKSLDSYR 317
Q95ZJ9       207 HVFCKNSSVM-PaDRTFSEQI-------------EGRKNVILLGDSVGDAFMDVGVEEEQVSLKIGFVNHDADKLVDKYL 272 Caenorhabditis ...
4NV0_A       281 DTFDIVLVDDQTMDVPRTLLSLIE 304
XP_002026381 280 KTFDIVLVDDQTMDVPRALLALIE 303
Q17PQ5       274 ETFDIVLIDDQTMDVPRAILEMIK 297 yellow fever mosquito
Q7QE29       269 DAFDIVLVDDQTMDIPRAIVDMVK 292 Anopheles gambiae str. PEST
Q5ZID6       308 DSYDIVLVKDESLEVANSILQKIL 331 chicken
CAF93645     299 DSYDIVLVKDETLEVPNAILQRIl 322
Q3UFY7       266 DSYDIVLEKDETLDVVNGLLRHIL 289 house mouse
Q5ZKF6       263 DAYDIVLESDETLDVVNGILRYIL 286 chicken
XP_002264488 318 KAFDLVYLNDGPMWGVVKLVSQLC 341
Q95ZJ9       273 NYFDIVLVDDQSMDIPNQILEAIY 296 Caenorhabditis elegans
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