1LQK,1NPB


Conserved Protein Domain Family
FosA
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cd07244: FosA 
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fosfomycin resistant protein subfamily FosA
This subfamily family contains FosA, a fosfomycin resistant protein. FosA is a Mn(II) and K(+)-dependent glutathione transferase. Fosfomycin inhibits the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA), which catalyzes the first committed step in bacterial cell wall biosynthesis. FosA, catalyzes the addition of glutathione to the antibiotic fosfomycin, (1R,2S)-epoxypropylphosphonic acid, making it inactive. FosA is a Mn(II) dependent enzyme. It is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.
Links
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Statistics
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PSSM-Id: 319908
Aligned: 22 rows
Threshold Bit Score: 202.127
Created: 20-Mar-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Mn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:Mn(II) binding site
  • Structure:1LQK_A; Mn(II) binding site of FosA from Pseudomonas aeruginosa
  • Comment:Both Mn(II) and K+ are crucial for efficient catalysis.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                                                           #                
1LQK_A         4 GLNHLTLAVaDLPASIAFYRDlLGFRLEARWdQGAYLELGSLWLCLSrepqyg---gpaadYTHYAFGIAAADFARFAAQ 80  Pseudomonas aer...
AAZ14834       4 GLNHITIAVsDLGRSLAFYTDiVGMLAHVRWdNGAYLSLGGVWFCLScdkvm-----pskdYSHIALDISEDDFASFLEK 78  Achromobacter d...
AAP50248       4 GINHITFSVrDLRASIEFYRDlLGMKLHVFWdTGAYLTAGNTWLCLSlgqpe-----pakdYTHVAFSVREGELLELRAK 78  Pseudomonas aer...
EPJ53728       4 GINHITIAVsDLERSVAFYQQrLGMLLKVTWaKGAYLEVAGQWICLSvdraq-----psrdYSHIAFDISEQLFEQYSRS 78  Osedax symbiont...
WP_045978561   4 GINHLTLTVhDLRRSLQFYSElLCFTPLVRWrQGAYLQNQELWLCLNvgrpq-----paqdYSHIALTVEPNRFCELQQR 78  Pseudoalteromon...
WP_009835938   4 GLNHITLSVsQLEHSLDFYQNlLGFKAHVKWdNGAYLSLPGLWLCLSlgrte-----svkdYTHFAFSLSESDYERLVIK 78  Marinomonas sp....
WP_028021573   4 GINHVTLAVsNLDASLKFYIGhLGFTGHVRWnTGAYLTLGDFWLCLSvdepc-----dksdYTHLALDIDEQAFDVMADK 78  Enterovibrio ca...
ETI62289      84 GFNHLTFSVsDLDRSIAFYSElLGFSGEVRWaTGAYLSYGNCWLCLSlgnvs-----ssqdYTHVAFSFDAAAMWHITQK 158 Marinomonas sp....
WP_023401350   4 GINHITLSVsNLMRSIEFYQN-LGAIAHVRWqSGAYLSFGELWLCLSiceqpssklnaqedYTHFALNIEPENFIEYRQK 82  Pseudoalteromon...
CDG40867      24 GINHVTLCVrDLDRSIPFYRDlLGCALRERWeKGAYLEAGSLWLCLEllpdsq--aisrrdDSHLAFTVEPAGFTPMCER 101 Asaia platycodi...

Feature 1                                     #               
1LQK_A        81 LRAHGVREWKQNRSEGdSFYFLDPDGHRLEAHVGDLRSRLAACRQ 125 Pseudomonas aeruginosa
AAZ14834      79 LRRADVTEWKQNSSEGySVYFLDPDGNKLEAHSGSLQSRLSSLKD 123 Achromobacter denitrificans
AAP50248      79 LKQAGVEEWKQNTSEGdSIYLLDPNGHRLELHCGTLATRLAELES 123 Pseudomonas aeruginosa
EPJ53728      79 LMASGVDLWKENKSEGdSMYILDPDGHKLEIHVGTLTSRLQKMRE 123 Osedax symbiont Rs2
WP_045978561  79 LTAADVCFWQENSSEGsSLYFLDPDGHKLEAHVGDLGSRLAAIAQ 123 Pseudoalteromonas ruthenica
WP_009835938  79 LKQYGVKQWQENTSEGeSFYFLDPDGHKLELHLGSLETRLAELKT 123 Marinomonas sp. MED121
WP_028021573  79 LRASGVKEWKDNRSEGrSIYILDPDGHKLEVHTGGLSQRLKSLKK 123 Enterovibrio calviensis
ETI62289     159 DGFPSVTQWQKNTSEGdSLYLEDPDGHKLELHSGSLTTRLESLRK 203 Marinomonas sp. D104
WP_023401350  83 VERLELQHWQQNRSEGeSLYILDPDGHKLEVHVGSMQSRLNSLKA 127 Pseudoalteromonas luteoviolacea
CDG40867     102 LLGKVTLWKQNRSEGD-SLYFLDPDGHKLEIHVGSLLTRLRSLHA 145 Asaia platycodi SF2.1

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