Conserved Protein Domain Family
DUF4639

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pfam15479: DUF4639 
Domain of unknown function (DUF4639)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.
Statistics
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PSSM-Id: 464739
Aligned: 13 rows
Threshold Bit Score: 849.865
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005599954   9 ERQIR-DRGVTRSKAEKVRPPTVQVPQVDIVPGRLTEAEWMAFTALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPF 87 
XP_021584817  12 ERQAR-DRGMTRSKAEKARPPTVTVPQVEIVPGRLNEAEWIALTAIEEGEDVVGDILADLLARVMDSAFQVYLTQQCIPF 90 
Q9DAQ4         6 SRQAR-DRGVTRSKAEKARPPTQPVPQVDIVPGRLNEAEWIAFMSLEEGEDVVGDILADLMTRVMECAFKVYLTQQCVPF 84  house mouse
XP_016835523   6 SRQVR-DRGVTRSKAEKARPPTQPVPQVDIVPGRLNEAEWIAFMSLEEGEDVVGDILADLLTRVMECAFKVYLTQQCVPF 84 
EHB01721      26 ERQAR-DRGTTRSKVEKARPPTVPVPHVDIVPGRLSEAEWIALLALEEGEDVVGDILADLLARVMDSAFQVYLTQQCIPF 104
XP_003793514   9 ERQMRgDRGVTRSKAEKARPPTVPVPQVDIVPGRLNESEWMALTALEEGEDVVGDILADLLARVMDSAFQVYLAQQCIPF 88 
NP_001103658   6 PRQVR-DRGMTRSKAEKVRPPTVPVPQVDIVPGRLTEAEWIAFTALEEGEDVVGDILADLVARVIDSAFKVYLTQQCIPF 84 
EFB18649       4 ERQIR-DRGVTRSKAEKARPPAVQVPQVDIVPGRLTEAEWMALMALEEGEDVVGDILADLLSRVMDSAFKVYLTQQCVPF 82 
ELW64008       7 ERQVR-DRGVTRSKAEKVRPPTVPVPQVDIVPGRLNEAEWMALMALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPF 85 
XP_008252936   9 ERQAR-DRGVTRSKAEKARPPTVPVPQVDIVPGRLNEAEWIALTAVEEGEDVVGDILADLLARVMDSAFKVYLTQQCVPF 87 
NP_001231805   9 ERQAR-DRGMTRSKAEKVRPPTVPVPQVDIVPGRLTEAEWMALSVLEEGEEVVGDILADLLARVMDSAFKVYLTQQCIPF 87  pig
XP_023408560  24 ERQAR-DRGVTRSKAEKARPPTVPVPQVDIVPGRLNEAEWMALAAIEEGEDVVGDIIADLLARVMDSAFRVYLTQQCIPF 102 African savanna...
XP_017819716  24 eRQVR-DRGVTRSKAEKVRPPTVPVPQVDIVPGRLSEAEWMALTALEEGEDVVGDILADLLARVMDSAFKVYLSQQCIPF 102 white-tufted-ea...
XP_005599954  88 TISQAREAMLHITEWRFLARDEGESAVAEDPTWGEDEEPSACTTDAWAQGSVPVLHAPASVGL-----EETFQGE----- 157
XP_021584817  91 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHTPASEVL-----EENCQVE----- 160
Q9DAQ4        85 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDSWAQGSVPVLHTPAPVCV-----EEQFHNE----- 154 house mouse
XP_016835523  85 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHAPAPVGV-----EEHFQGE----- 154
EHB01721     105 TVSQAKEAMLQIVEWRFLARDEGDAAVAEDPTWGEDKEPLACVTDTWAQGSVPVVHAPACESLedfedEDEDKDE----- 179
XP_003793514  89 TISQAREAMLQITEWRFLAHDEGESAVAEDPTWGEDEEPSPCTTDSWAQGSVPVLRAPTLEGP-----QENLQGE----- 158
NP_001103658  85 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHARASMGL-----EETFQGE----- 154
EFB18649      83 TVSQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPFACTTDAWAQGSVPVLHAPAFMGP-----EDTFQGE----- 152
ELW64008      86 TISQAREAMLQITEWRFLARDEGESAVAKDPTWGEDEEPLACTTDSWAQGSVPVLHTPAAEGM-----DETLQDE----- 155
XP_008252936  88 TISQAREAMLQIAEWRFLARDEGESAVAQDPTWGEDEEPLPCTTDAWAQGSVPVLHGRLSEGQ-----EETFQSE----- 157
NP_001231805  88 TISQAREAMLQITEWRFLARDEGETVVAEDPTWGEDEEPSACTTDAWAQGSVPVLHAPTSVGL-----EETFPGE----- 157 pig
XP_023408560 103 TISQAREAMLQITEWRFLARDEGESAVADDPTWGEDEEPLACITDAWAQGSVPVLHAPASVGP-----EETLQ-Evspap 176 African savanna...
XP_017819716 103 TINQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPSACTTDSWAQGSVPVLHAPASEGL------ENFPGEvhssg 176 white-tufted-ea...
XP_005599954 158 -------------------------DQGSVDQIPIGRSWMDRGSQEQMESWEGSp-eLRVIpgPGPPPTP--------EL 203
XP_021584817 161 -------------------------DLENLDRIPLRRSWPGRASQELTESREHS---LSVT--LGPQPNP--------EL 202
Q9DAQ4       155 -------------------------EPGNPDQFLLGSSW-DKESQKPTQPSEPSa-ePKVT--PRPTATL--------EA 197 house mouse
XP_016835523 155 -------------------------EPGNSDRFLLGSPWLDRDSQEPTASSQPSa-eTRVI--PGLTPTL--------EE 198
EHB01721     180 -------------------------DPGSRGRILLGRSWLARGSQERFp-------eLRVT--PGPPATP--------EL 217
XP_003793514 159 -------------------------GPRNLDQMPLGRSRMSRGSQELRQPWEPSq-eVRIN--PSTPPMP--------DV 202
NP_001103658 155 -------------------------DQDSVDQIPLGGSWTDSGSQEPMESWe-----LTVT--PDSPPTP--------EL 194
EFB18649     153 -------------------------DQGRV---------MARGSQEQMESWEHSp-eLQFT--PGPPPTP--------EL 187
ELW64008     156 -------------------------D-------PLGKPWIERDSQEEAESQe-----LRVT--PGPVPTA--------EL 188
XP_008252936 158 -------------------------DTESQDQSPLGRLWLDRHSQGQTGSWEPSp-eLRAT--SGRPLTP--------EP 201
NP_001231805 158 -------------------------DRGSVDQITLGRSWMDTGSQEPMEPWDRClpeQRVV--P--SSTL--------EL 200 pig
XP_023408560 177 glsarspslp-fptsqwpsplafpqDRGSVDRSPLKRSWVGRGSQEQMESLERS-----------PEPGAcpgpppapEL 244 African savanna...
XP_017819716 177 assdssaltpglpfptshcpsafsqDPGGVDQIPLGRSWIGRGSQEQKESWETSp-eLRVT--SAPSPTS--------EL 245 white-tufted-ea...
XP_005599954 204 FQEAGPRGPLE--ELDGQAIG---HLSSAGSLNG----NLQ---PSVETAHTGSPHSSLELSLVASPEASAERAQA--LS 269
XP_021584817 203 FQEAELGDTLE--EPDRGARS---HSSLVGFLNG----SVQ---PSLEVELAESPRPFLELSQVALPRASVGSQSPphLR 270
Q9DAQ4       198 FEEAEPGDALE--VPHGQEGS-----------HMlavpSKEslrSTAEGERVYSPQSSLKQPQVVRLQASEKESS---FG 261 house mouse
XP_016835523 199 FQEAEPQDDFE--EPDGQEQSdvlVTSLKEPSHIltgpSKQsspPS-----AHSPQLSLDLPHVVSLQISEKGSSS--LS 269
EHB01721     218 FQKAGAGGALQ--EPDGQARS----LFLAGSLNE----NLQ---RSGEAEGIQSPHPSLELSQVASPLASAVRGQP--LG 282
XP_003793514 203 FQEAGPRDPLE--EPD---------PLITKSLNK----SFQenfQSVQVASADSPGP-LELSLVASPKALAKTVQP--FD 264
NP_001103658 195 LQETGPRSPLE--KLGDQSRSdqtDLFAVGSSNS----SSQ---LSMEMVPAGSTHASLELSLVASPQASVERAQP--IS 263
EFB18649     188 FQETGSRGPLV--DLDIQARD---HQATVRSLNV----SRQ---PSVELAPDGSPHPSLELSQVASTQTLARRAQP--RG 253
ELW64008     189 FQEAEPGGSFE--EPVDQMRD---PPSSAGSLSA----CFQ---PCAEGAPADSPPTPPELSRLASPQASTPSGQF--LK 254
XP_008252936 202 FPEAGPGDVLE--EAD----S---HLSSAESLHS----FQL---PWVEVGPREGPHPSLELSQVASPQAPALRPQS---G 262
NP_001231805 201 LKETGPRGPLEelELDGQARG---HLSSVGCLTV----SSQ---LSMEMAVAGGPHLSLEPTPVASPKGSVEKAQP--FS 268 pig
XP_023408560 245 FQEAGPGEPLE--ELDDQERG---AVSSAESCNA----SFH---PSEEMASAGSPEPSEEEFLEAGSQTPEETGQP--LS 310 African savanna...
XP_017819716 246 FQGAGPGGPVE--EADCQSRG---RFSSAGSSSA----SFQ---LLVEKAPADDANLSLEPTVVASPQASTERRQP--FG 311 white-tufted-ea...
XP_005599954 270 SQFSLEDLYYCTPQLHAAGDRPELKKEEMPRIASPVSVASSSAGGSTMLRLSASFQpQQQPGRPEAGLS-APQYM----- 343
XP_021584817 271 SPLSLEDFYSCISQPDAAGDQLKRKTQAMSPNASGVLVPFSSKGDTSALSASVSSQ-SQQSVYLDSQRRgTLQSR----- 344
Q9DAQ4       262 SHLSLEDLYLCMPQPDAAGDRLSLQSKG--QLHSSPIGSESHLGALTPAEPSAF----QEP-------E-VLGER----- 322 house mouse
XP_016835523 270 SHLSLEDLYNGLPQPDAAGDRLKRESKGTPRAPS--VGSVSLLSALTLERPSWS----QLP-------E-CLDSP----- 330
EHB01721     283 SCLSPKDLY---PQPDAAGDRLLNVTEGMSCMASGV--SCLSRGGPPSLSPSASLQ-SYQPG----RLG-EPHYR----- 346
XP_003793514 265 SQV-LENLCYGLPQVDAAEDQLELKTKGVPRAASGV--PVPTVGSPTRFSPSASVQ-PQWPLSLDVQLS-MPPYR----- 334
NP_001103658 264 SQFSLEDLYNCTPQPHAAGDRLELREEKVPLIPSRVLVSDPSAGGPTTLNPSAGFQ-PQPPWLAEERPS-ALHSR----- 336
EFB18649     254 SQSLLEDLHYCTSQPHVAGDGLKCKKEDVPRISSGVSGAGLSSGSSTTLSRFASLE-PRQPRFTDALRS-GLPYR----- 326
ELW64008     255 SQLSLEDLRYCTSQPDAAGDRPELKTAGAPYVASGVSASGTSLGDPTQISPSASFQ-SQQPGGWNAWPR-TPHPR----- 327
XP_008252936 263 SLLSLEDLYYCMPDKDAAGDRMELKREELPPVASAAALSVGSEDRPTQLGPSVPFR-WQQPGRWHARLN-PPRSR----- 335
NP_001231805 269 SPFSLEDLYYCTPQAQAAGDRMEPKKEEVPFISSSGSVSGTSAGGLSTLSSSSGFQ-PQQLWRPDARPS-SLRGR----- 341 pig
XP_023408560 311 NQLSLGDLYYCAPQPDEAGDRAELEKEGVSPIASGTLLSCPSVDSPTRLSPSASLW-SQQP-------------Rraeaw 376 African savanna...
XP_017819716 312 FHLSLEDLYCCMPQLDEAGDQLEHKSDGVLSLASGVWVSCPSVGDAT--HPSVSFQ-QQQA----------EHHR----- 373 white-tufted-ea...
XP_005599954 344 -------VGRR-MVGARLDPARLPRLWVSPLAKVLLP------------DSEARPVEAYRGRPRg-EKTEA---PAGAGT 399
XP_021584817 345 -------VDRK-AAEVRLDPARLPRHWVRPLAEVLVP------------DSKVHPLEAYRKRQR--GKIQA---QVGLQA 399
Q9DAQ4       323 -------PKHK-TTTLRMDSSRLPRHWVRPVAEVLIP------------DLEVHPLEIYRGRPR---RSQAgtaTSACES 379 house mouse
XP_016835523 331 -------QTRK-MPMVRLDPARLPRRWVRPVAEVLIP------------ETETRPLEIYRGRPRg-EKSQAgarTPASRS 389
EHB01721     347 -------AGCK-ATTAHLDPEQLPRHWVRPLAETVIPdsdacpletyllDSDARPLETYLGRRRh-CKTKT---RARPQG 414
XP_003793514 335 -------AR---KAATRLDPARFPRQWVRPLAEVLIP------------DSEAHPLETYRGHQHssEKTQT---PAEPQS 389
NP_001103658 337 -------IGRK-GTTARLDPARLPRPWVRPLSEVLVP------------DSEGRPLEAYRGRQRg-EKTEA---PAGPQA 392
EFB18649     327 -------MGLK--AGACLDPTRLPRHWVRPLAEVLVP------------DSEARHLEAYRGRRRv-AKTKAsqpSARPLA 384
ELW64008     328 -------PGRK-PTVARLDPARLPRHWVRPLAEILIP-------------DDAGPLESYRWRPQs-GKTEG---RDTSLG 382
XP_008252936 336 -------MDRR-ATRRRLDSARFPRHWVQPLATVLIP------------SSERYSMEAYCGHQQs-KKTKA---QAVPQF 391
NP_001231805 342 -------IGPS-AEMERLDPARLPRRWVRPLAEVLVP------------NSEMRPQKAYRGCLQs-RKTEA---PAGPQA 397 pig
XP_023408560 377 ldalhhrAGGKvGGTARLDPARLPRHWVRPLAEVLVP------------GTEACLLEAYRGRRR--NKTDA---RATPQA 439 African savanna...
XP_017819716 374 -------MPCK-AALKRLDPARLPRHCVRPLAKVLVS------------DSQKRPLETYHGRQQd-RKTKT---RAKPQA 429 white-tufted-ea...
XP_005599954 400 PRTGVRVSS-----AVFLPLPPGVPS-RDFGPDprPGLQIPSLSLGLPSPGSGSKLPFPSPGLRFLATHPVLPDVARNPS 473
XP_021584817 400 PGPHVPASL-----AAFFPLQSDVPF-RVVGPE--PRLQLPTLNLGPPSLSFGSKLPFPSPGIHFLDTHPAVVEAAHRSS 471
Q9DAQ4       380 QALSSRAPSkphvsSPRFPLQRCATF-RALGPD-------PSLNLAQTSPSFGSNVPFLSPGFRFLPRNPIPPDVASTPT 451 house mouse
XP_016835523 390 QALGLHAPPklqasPLKFPLPCNAPF-RALGPD-------PTLNLAQSAPTFGSKLPFLSPGFRFLPTKPGPPEVSSSPS 461
EHB01721     415 PVSGDRVSP-----AAFFPFQPKGP--CALGPD-------AALNLAPLLPSSRAKVPFPSHGAHFLPKHPVLAEVPRSPS 480
XP_003793514 390 PIPGASVFQ-----AAFFPFRSGVPF-RALGPG--PKVQSSTLNLNLPSPTFGSKIPFPSPGLRFLTKRPKLLDVAHIPS 461
NP_001103658 393 SRPSCRVSR-----SEFFPFPPGVPV-RTLGPG--LSLQFPTLNLGLPSPGFGSKLPFPSPGLRFLATHRARPDMARSPS 464
EFB18649     385 SGPGVRVSP-----TVFFSLPPSTPF-HALGRS--PGLQSPTLSLGLPSPGFGSKLPFPRPGLGFLATHLAFPDLARSPS 456
ELW64008     383 SDAAAPVSP-----EAFVPLRLGVPSqRSLVNG--SGLQFHTVNLGLPSPPFRSKIPFPSSGLRFLATHRALPALPHSSS 455
XP_008252936 392 PGPGDCTSP-----AMFFSLHPGTPF-RPLGRG--RRLKFPTSNLGPLESSSGSKMPFFSPRLHFLAPQPKLPEEARSLS 463
NP_001231805 398 PGPDVRVSP-----SVFYPLPPGVPF-RALAPG--RRLQFPTLSSGLPSPGFGSKLPFPSSRLRFPITHSVLPDVAHSPS 469 pig
XP_023408560 440 REHGHRVSP-----AAFVPLRPGVPF-HALDSR--LGLQFPSLR----SPVLVSKMPFPSPGLRFLTTHPTLPDVARSPS 507 African savanna...
XP_017819716 430 PSPGTRVSP-----ATFFPLQPGVPF-RPSDSG--PTLQFPTLNLGLSSPCFLSKLSLPSSGIRLLTTHPVFPDVVCSPS 501 white-tufted-ea...
XP_005599954 474 PKLWPGTKWPSGWDGEVELLEDLWAGRARVSPQGVPP---QG-LDpHKWPHPEPQVLEATSQVMWKPMLLPEAMKLAPGV 549
XP_021584817 472 PSVWPRAKWPSGWEREADLLGNLWAGRTRVPPQGLGLaekEG-QA-SGWPQTMPQVLEATSQVFWKPVLVPEAVKLTPGV 549
Q9DAQ4       452 PKLWPLAKWPSGWEREAEQLGELWAGRTRVPPQGQEPvevTPlEEdSGWPLAAPQVLEATSQVLWKPMVISETMKLVPGV 531 house mouse
XP_016835523 462 PKLWPRAKWPSGWEREAEQLGELWGGRTRVPPQGQEPaadDA-SDdSGWPLAAPQVLEATSQVLWKPMVLSETMKLVPGV 540
EHB01721     481 PKSWPNTKWPRGWEGRAELLGKLWAGRTRVPPQGLEPadkED-QD-FGWPQIAPRILEASSQVLWKPVVRPEVVRVAPGV 558
XP_003793514 462 PKLWPSAKWPTGWEGEAEMLGDLWAGRTPVSAQGLEPtyrEG-QDlQRWPRTTRQVLEATSQVLWKPMLLPEAMKLAPGV 540
NP_001103658 465 PKLWPGAKWPSGWEGEAELLGELWAGRTRVPPQGLDLgdrES-QDpHQYRHPVPQVLEATSQVTWKPVLLPGALKLAPGV 543
EFB18649     457 PKLWPGAKWPSGWEGEAELLGEVWAGRSRVNPQGLDPrdrEG-QDpHRWPQMAPRVLEATSQVMWKPMLLPDAMKLAPGV 535
ELW64008     456 PKQWPSAKWPRGWEAEAEQLCELWAGRTRVPPQGPRPt-eEG-QGaRGRAETPPHVLAPTSQVLWKPLLLPEAVRLTPGV 533
XP_008252936 464 PKPRPSAKWPSGWEWEAELLDELWTGQTRAPSRGLGTidkEG-QDhDGWPQPA-QVLEATTQVLWKPLLQPEAVKLAPGV 541
NP_001231805 470 PKLWPGAKWPSGWEGEAELLGELWAGRTRIPPQGLDPgyrES-QDpHKWPHPAPQVLEATSQVMWKPMLLPEALKLAPGV 548 pig
XP_023408560 508 PKLWPSAKWPSGWEGEAELLDELWAGRTRVPPQRLDPgdrKG-QDsRGWPLLAPRVLEATSQVMWKSVLLPDAMKLEPGV 586 African savanna...
XP_017819716 502 PKLWPSARWPSCWEQEAELLSELWAGRTRIPSQGLELedrEG-LDsGRWPQTTPQVLEATSQVMWKPLLLPEAMKLAPGV 580 white-tufted-ea...
XP_005599954 550 SMWNPTTQVLLSSAIPQQEDK-GQASPP-IEQQPIQTGAPKP 589
XP_021584817 550 SMWNRSTQVLLNSAVSQEEVKeGGTSPA-VEQRPIQKGVSKP 590
Q9DAQ4       532 SMWNRGTQELLNPAVIRKEAEeGTPQAP--EQQPIQTGVSKP 571 house mouse
XP_016835523 541 SMWNRGTQELLSPDAILEEAEgGTSNGA--EQQPIQTGVSKP 580
EHB01721     559 SMWNRSTQVLLSSAVP-QEAKeGGTFSS-IDQHAIQTGVPKP 598
XP_003793514 541 SMWNPATQVLLSSAVPQQEDKeGGTFPP-IDQHPIQTAPLKP 581
NP_001103658 544 SMWNPSTQVLLSSSEPQRNDReGSASP------PIHTGAPKP 579
EFB18649     536 SMWNPSTQVLLRAAVPQQEDKeSVTSLP-IEQHPIQTDAPKP 576
ELW64008     534 SMWSPNAQVLLSSAVPPQENKdGSCSPS--EQHPIQTSAPRP 573
XP_008252936 542 TLWEHGTKVLLSSAVSQEENQeDSTSPPtEQQHPIQMGAPKP 583
NP_001231805 549 SMWNPTTQELLSSAEPQQEDKkGSTSP------PIHTGAPEP 584 pig
XP_023408560 587 SLWNPSTQVLLSASEPQEEDKeGRISPP-VEQHPIQTGAPKP 627 African savanna elephant
XP_017819716 581 SMWNQSTQVLLSSGVPELEDKeGDTFPL-IEQQPIQTGPPKP 621 white-tufted-ear marmoset
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