6SSR,4NTF


Conserved Protein Domain Family
MAPEG
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pfam01124: MAPEG 
MAPEG family
This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
Links
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Statistics
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PSSM-Id: 460074
Aligned: 163 rows
Threshold Bit Score: 34.966
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6SSR_B  14 LA--AVSILSACQQSYFALQVGKARLkykvtppavTG-------SP----EFERVFRAQQNCVEFYPIFIITLWMAGWYf 80  human
Q89M34   6 FW--LTLTVIFTGILWVPYILDRCQVrgl---sgaMAnps--rsDKpqspWATRLMFAHDNAVENLVIFAPLVLILNAId 78  Bradyrhizobium japonicum
Q1GLI7   7 AL--AATVLIHVVTVIWSQRALEADIgr-----dgNVgtr-enlDErlseRSNRLRRALANHTENIGPFIIAVLLLTLTd 78  Ruegeria sp. TM1040
Q21CX4  10 VL--GWSVVLLIVQLFLASVPVTLELgg-----ayQAgpr-dqpRAakgvFAGRAARAFRNLLETYPAFVALALALSVTg 81  Rhodopseudomonas palu...
Q2YLS4  12 LPliGWSVVLLVVHILLQSMMATQELgsrwnagprDe------sLKpsgrLAGRAERASANFRETYPAFIALALALVLKg 85  Brucella abortus 2308
Q8P7G3   9 ML--GWAMVLGLVQLLAASTSMTAQRgt-----kwNAsar-dgeTKpltgVAARLDRAFRNFLETFAIFAAAVLAVTVAg 80  Xanthomonas campestri...
Q9A7V1   9 MI--AVAVAIGILNLLWASAAAQPQRgl-----kwNVgpr--deTIeltgMAGRLMRAFANFRETFPFFVALVIVDYLGg 79  Caulobacter vibrioides
Q5NQE5   9 LL--GIVLLLALLQIFLTAHFKTRQYgy-----kwNVsar-deaLPplspMAGRLSRAQANLFETLPLFIAALLANLYLg 80  Zymomonas mobilis
Q5LTX7  10 GI--LTCLMILAASLWIPYVVGIATDps------qEEafarpaqISnlrpWVQRAHRAHLNLLEQSMPFAVLVLILALMn 81  Ruegeria pomeroyi
Q28TE5   9 GV--LTCLMLLAASLWIPYIVGVNKYer-----egVDsfqrppgDDglpdWVARANRAHLNLLEQGMPFAVIILILHLAd 81  Jannaschia sp. CCS1

6SSR_B  81 -NQVFATCLGLVYIYGRHLYFWGYSEA-AK--KRITGFRLSLGILALLTLLGAL 130 human
Q89M34  79 ySSKWTVLACAVYFWSRVAHLIVYAMGiPV--FRTLAFTVGFLAQAVLALAIFK 130 Bradyrhizobium japonicum
Q1GLI7  79 nASSLTAICAWTYVAARALYVPAYAFAwVP--WRSVIYVIGLLATLLMIGASFF 130 Ruegeria sp. TM1040
Q21CX4  82 rSGGWGALGAEIWLAMRILYVPAYLIHfPF--ARSLLWFASLLALLAMLARLLL 133 Rhodopseudomonas palustris BisB18
Q2YLS4  86 dPSGWGILGAWLWFFSRIVYIPLYLAGiPY--LRSFVWLISLVRLGIMLLALVL 137 Brucella abortus 2308
Q8P7G3  81 rTNAETALGVQLYLWARVAYVPVYALGiPY--LRSAIWVVSFWGIVKLVRALLG 132 Xanthomonas campestris pv. campestris
Q9A7V1  80 rLGDLTVYGAALYVAARAAYLPLYAFGvPY--VRSLVWLASMVGILMLLAALVV 131 Caulobacter vibrioides
Q5NQE5  81 hNGYYSELSAELYVASRLIYLPLYAFGvPY--LRSIVWAIGIIGLLGQILLIFC 132 Zymomonas mobilis
Q5LTX7  82 gFSTLTYWTAIAFFWVRVLHAAGMISGyARmpLRPILFSAGWVCTLLMAYAIFA 135 Ruegeria pomeroyi
Q28TE5  82 gFTAVTYWTAIVFFWLRVAHAVGMITGtARmpLRPLIFTAGWVCIMILGVSAFM 135 Jannaschia sp. CCS1
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