2NRY,3UIM,2OID


Conserved Protein Domain Family
STKc_IRAK
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cd14066: STKc_IRAK 
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Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270968
Aligned: 23 rows
Threshold Bit Score: 266.831
Created: 5-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #####   #            # #                                     #                 #
2NRY_A     39 MGEGGFGVVYKGYVn--NTTVAVKKLAAmvdi---tteeLKQQFDQEIKVMAKCq--HENLVELLGFSSdg--dDLCLVY 109 human
2OID_A     33 MGEGGFGVVYKGYVn--NTTVAVKKLAAmvdi---tteeLKQQFDQEIKVMAKCq--HENLVELLGFSSdg--dDLCLVY 103 human
P51617    218 IGEGGFGCVYRAVMr--NTVYAVKRLKEnadl---ewtaVKQSFLTEVEQLSRFr--HPNIVDFAGYCAqn--gFYCLVY 288 human
NP_973956  49 IGTGGYSSIYLARVs--GSINAALKVHVss-------hrLYQVFRSELEILLRLq--HPHIVKLLGYFDds--eSGALLL 115 thale cress
NP_567053  55 ISSWGYFIWYKGVIe--ERQVSIKKWSSqn-------lsSFTEAYRDISVSSQMs-gHKNALKLIGCCLef--dLPALVC 122 thale cress
AAK37545  191 IGKGGYGTVYKGELkgtGGIVAVKRLHSgndtsqngsreRLRQSLTELRTLARFr--HDNILPIYAYSLeg--sEPCLVY 266 nematode
Q05652    219 LGQGGFGDVYRGKWk--QLDVAIKVMNYrspni-dqkmvELQQSYNELKYLNSIr--HDNILALYGYSIkg--gKPCLVY 291 fruit fly
NP_180839 538 VAEVDFGTAYYGLLn-gDQHIVVKRLGMtkc------paLVTRFSTELLNLGRLr--HRNLVMLRGWCTeh--gEMLVVY 606 thale cress
ABA94280  349 LATGSSYNIYKGTLe-dNTLVAVKKYFDry-------eaGKEEFRSRVAMVIMSpvvHKNITKLLGICLea--nPPTLVY 418 Japanese rice
NP_182059 423 LGKSNVSSVYKGILr-dGSVAAIKCIAKssc------ksDESEFLKGLKMLTLLk--HENLARLRGFCCskgrgECFLIY 493 thale cress

Feature 1     ###   #                                                 # # ## #          #     
2NRY_A    110 VYMpNGSLLDRLScld---gtPPLSWHMRCKIAQGAANGINFLHE-----NHHIHRDIKSANILLDeaFTAKISDFGLAR 181 human
2OID_A    104 VYMpNGSLLDRLScld---gtPPLSWHMRCKIAQGAANGINFLHE-----NHHIHRDIKSANILLDeaFTAKISDFGLAR 175 human
P51617    289 GFLpNGSLEDRLHcqt--qacPPLSWPQRLDILLGTARAIQFLHQd---sPSLIHGDIKSSNVLLDerLTPKLGDFGLAR 363 human
NP_973956 116 EYLpQGNLQEKLNrn----skQVLPWRNRTAIAFQVAQAIEHIHEkc--sPQIVHGDIKSSNILLDkhFNSKLCDFGSAK 189 thale cress
NP_567053 123 EYTeHGPLNRDGGls----sgVVLPWKVRLKIAKEIASSVTYLHTaf--pETIVHRNINPTNIFIDenWTAKLSDFWFCV 196 thale cress
AAK37545  267 QFMsNGSLEDRLLcrk---gsVPLTWIQRKEISIGAGRGLGFLHSfg--kTPIIHGDIKTANILLDkhMEPKIGDFGLCR 341 nematode
Q05652    292 QLMkGGSLEARLRahkaqnplPALTWQQRFSISLGTARGIYFLHTar--gTPLIHGDIKPANILLDqcLQPKIGDFGLVR 369 fruit fly
NP_180839 607 DYSaNRKLSHLLFhnhi-pgnSVLRWKSRYNVIKSLACAVRYLHEew--dEQVIHRNITSSTIFLDrdMNPRLCGFALAE 683 thale cress
ABA94280  419 EYA-ARNLSDILHc------kEDFPLELRLKIASKTSRVLEHLHSs---rIALRHGDVMPSNILLDdgFVPKVTAFTLST 488 Japanese rice
NP_182059 494 EFVpNGNLLQYLDvkd--etgEVLEWATRVSIINGIARGIVYLHGengnkPAIVHQNLSAEKILIDhwYNPSLADSGLHK 571 thale cress

Feature 1                                                                                     
2NRY_A    182 ASekfaq-----------tvmxSRIVGTTAYMAPEALrg-eiTPKSDIYSFGVVLLEIItGLPAVDEhrep----qllLD 245 human
2OID_A    176 ASekfaq-----------xvmxXRIVGTTAYMAPEALrg-eiTPKSDIYSFGVVLLEIItGLPAVDEhrep----qllLD 239 human
P51617    364 FSrfagssps----qssmvartQTVRGTLAYLPEEYIktgrlAVDTDTFSFGVVVLETLaGQRAVKThga------rtKY 433 human
NP_973956 190 VGfssmvqpskttstmsprskqVMMIGSPGYTDPHYLrtgiaSKKMDMYGFGVVVLELVsGKEAVSSergemlvhstaSL 269 thale cress
NP_567053 197 AIpege------------lyveDDVKGVIGFVDPDYYwtmkvTEKVDIYSFGVVMLVLLsGRAAVFNgpdea--pmslND 262 thale cress
AAK37545  342 DGhveaeam------ekhpliaSHIKGTLAYLAPEFItskilTTKLDVYSFGIVLLEIAsGQRAYSDsr-------etRG 408 nematode
Q05652    370 EGpksld----------avvevNKVFGTKIYLPPEFRnfrqlSTGVDVYSFGIVLLEVFtGRQVTDRvpen----etkKN 435 fruit fly
NP_180839 684 FLsrndkah-------qaakkkGSAQGIFGYMAPEYMesgeaTTMADVYSFGVVVLEMVtGQPAVDYkrkke-dalmvLR 755 thale cress
ABA94280  489 RFtedn------------atrmSMVKGDGNYMDPYYRhtnlvLLKSDVYSFGVVLLELItRKQPAGDcp-------ekYG 549 Japanese rice
NP_182059 572 LFtddi------------vfskLKASAAMGYLAPEYIttgrfTDKSDVYAFGMILLQILsGKSKISH-----------LM 628 thale cress

Feature 1                                                                                     
2NRY_A    246 IKEEIEdeek-----------------------------tieDYIDKKMNDad---------stSVEAMYSVASQCLHek 287 human
2OID_A    240 IKEEIEdeek-----------------------------tieDYIDKKMNDad---------stSVEAMYSVASQCLHek 281 human
P51617    434 LKDLVEeeaeeagvalrstqstlqaglaadawaapiamqiykKHLDPRPGPcp---------peLGLGLGQLACCCLHrr 504 human
NP_973956 270 IHEILDsngdig-------------------------eekvrQFLDPRLSRdgsi------dleEVKTMLRVAAFCLRsp 318 thale cress
NP_567053 263 HVSEVMekg------------------------------efdEIVDKEIWNdlggdddlvlrrsQVKAFLRLALRCVRy- 311 thale cress
AAK37545  409 LVEYCQvnkelaah---------------------rkipvreIFIDRRAPPlvgd-----eeksFLDALIEVGLAGANnd 462 nematode
Q05652    436 LLDYVKqqwr----------------------------qnrmELLEKHLAApmgk------eldMCMCAIEAGLHCTAld 481 fruit fly
NP_180839 756 IREVVGnrkk-----------------------------lleEIADIHLDDeye--------nrELARLLRLGLVCTRtd 798 thale cress
ABA94280  550 LVSEFAraykm--------------------------nksgkAMFDERIATeen--------ipVLEEIGKLALHCINlk 595 Japanese rice
NP_182059 629 ILQAVEsgr------------------------------lneDFMDPNLRKnfp--------evEAAQLARLGLLCTHes 670 thale cress

Feature 1                        
2NRY_A    288 KNKRPDIK--KVQQLLQEM 304 human
2OID_A    282 KNKRPDIK--KVQQLLQEM 298 human
P51617    505 AKRRPPMT--QVYERLEKL 521 human
NP_973956 319 PSLRPSAS--QVVQTLNKK 335 thale cress
NP_567053 312 KKEDPVSGmlEVAKELKLI 330 thale cress
AAK37545  463 RKVRPTMS--QIVEYLCKN 479 nematode
Q05652    482 PQDRPSMN--AVLKRFEPF 498 fruit fly
NP_180839 799 PKLRPSIS--QVVSILDGS 815 thale cress
ABA94280  596 LSKRPTMK--EVAERLKKI 612 Japanese rice
NP_182059 671 SNQRPSME--DVIQELNNL 687 thale cress

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