Conserved Protein Domain Family
hisC

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TIGR01141: hisC 
histidinol-phosphate aminotransferase
Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Statistics
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PSSM-Id: 273467
Aligned: 20 rows
Threshold Bit Score: 368.52
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q58365        11 RDVVKKLKPYVPgkskeeiaraygIKpeDIIKLGSNENPWGPSPKIKEKILDEID----KIHQYPEPVNPILMKELSKFL 86  Methanocaldococ...
P44423        23 RQNIQALTPYQSark-------lgGN--GTIWLNANEYPTSPE----FQLSGK------DLNRYPEPQPQRVVQAYANYA 83  Haemophilus inf...
P06986        11 RENVRNLTPYQSarr-------lgGN--GDVWLNANEYPTAVE----FQLTQQ------TLNRYPECQPKAVIENYAQYA 71  Escherichia col...
P07172        10 RPKIYNLEPYRCard-------dfTE---GILLDANENAHGPTP---VELSKT------NLHRYPDPHQLEFKTAMTKYR 70  Saccharomyces c...
O33770        27 RNKIKSWLLNASey--------dfTDikEGIRLHLNESPFEPPQFIIDAVKMYLS----KGNRYQHPDLLEKYRELAAEY 94  Sulfolobus solf...
P73807         5 RPSVRHTPAYVPgeq------pqtN---DFIKLNTNENPYDPPAQVLAAVAAELP----KVRLYPDPVSTQLRQAAADLY 71  Synechocystis s...
O06591        16 RADLRGKAPYGAp------------QlaVPVRLNTNENPHPPTRALVDDVVRSVReaaiDLHRYPDRDAVALRADLAGYL 83  Mycobacterium t...
WP_011715135  12 RPEILAMAGYTPgeq------pkpGE--QVIKLNTNENPYGPPEAVKQAMHAAIHd---NLRRYPSPDGYGVREAAARVL 80  Magnetococcus m...
WP_010894666  13 RQELRNFAGYSSars-------vaLT--GDLWLNANESAWPNP----ADS-HA------TMRRYPEPQPPKLRQMLAALY 72  Xylella fastidiosa
WP_010895944  10 RKNIKKLIPYQSarr-------igGEh-GNILLNANESPVSIF----FKLKKK------PFNRYPECQPSKLISSYAHYV 71  Buchnera aphidi...
Q58365        87 N-------------VDEENIIVGgDGADEIIDTIFRTFVDDG-DEVIIPIPTFTQYRVSATIHNAKIKYAKYDKEk-dFK 151 Methanocaldococ...
P44423        84 G-------------VSTENVLVT-RGGDEGIELIIHTFCEPKqDAILFCPPTYGMYAVSAETAGVLSKTVPLTDD---FQ 146 Haemophilus inf...
P06986        72 G-------------VKPEQVLVS-RGADEGIELLIRAFCEPGkDAILYCPPTYGMYSVSAETIGVECRTVPTLDN---WQ 134 Escherichia col...
P07172        71 NktssyandpevkpLTADNLCLG-VGSDESIDAIIRACCVPGkEKILVLPPTYSMYSVCANINDIEVVQCPLTVSdgsFQ 149 Saccharomyces c...
O33770        95 Sk------------VEPENIYPS-VGADGSIRAIFYNLVEPG-DTILTNYPSYSMYSVYSSVRGTKVIKVNLKEDnewWK 160 Sulfolobus solf...
P73807        72 G-------------VDLNQVLAG-NGSDDILNIVVRTFVDPG-ETVAFLDLTYSLYETIASVHGAKVQKIATDAN----- 131 Synechocystis s...
O06591        84 Taqt-------giqLGVENIWAA-NGSNEILQQLLQAFGGPG-RSAIGFVPSYSMHPIISDGTHTEWIEASRAND----F 150 Mycobacterium t...
WP_011715135  81 Gh-----------gLTPEQIILG-NGSDDLLTMLLRTFIDPG-QVVASMEPTYTLYEALVTIQGGCYRSVPWQPD----- 142 Magnetococcus m...
WP_010894666  73 G-------------CVPEQLLIG-RGSDEGIDLLVRAVCEPGcDPVLVTPPVFGMYAVSAQLQNAPVIQVPLVDDaagFH 138 Xylella fastidiosa
WP_010895944  72 N-------------LSCNQILAT-RGADEGIELLIKAFCEPGkDAIIYCPPTYDMYRINATIAGVEIKEIPTIKNt--WQ 135 Buchnera aphidi...
Q58365       152 LNVESVLN--NITDKTKVIFLCTPNNPTGNIIENRDVERVINEt---DALVVIDHAYIEYAKKeyDWTQKAPEYD-NVIV 225 Methanocaldococ...
P44423       147 LNLPEIK---NHLNDVKVVFVCSPNNPTGNLLKQSDILDLLQIta-gKAIVVVDEAYIEFCPEa-SVINLLKNYP-HLAI 220 Haemophilus inf...
P06986       135 LDLQGIS---DKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELtr-gKAIVVADEAYIEFCPQa-SLAGWLAEYP-HLAI 208 Escherichia col...
P07172       150 MDTEAVLTilKNDSLIKLMFVTSPGNPTGAKIKTSLIEKVLQNw--dNGLVVVDEAYVDFCGg--STAPLVTKYP-NLVT 224 Saccharomyces c...
O33770       161 ENTDDLL---AQAEKVELVIIDDPNNPTGSPMLNGKKELIGQLaentKGFVVIDEAYYEFGGy--TVSPYIYDYP-NVLV 234 Sulfolobus solf...
P73807       132 --FDLTGP--VICPEAKLIFLASPNPPKGKHLNREFLWQTCAQa---EGVVVIDEAYGDFSDE--DHWDFLQEFD-NVII 201 Synechocystis s...
O06591       151 GLDVDVAVaaVVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVap---gIAIVDEAYGEFSSQp-SAVSLVEEYPsKLVV 226 Mycobacterium t...
WP_011715135 143 GGLPLEG---LVALQPKLIFVTRPNAPTGHVVPLEQVAALCQAva-qSAVVVLDEAYGDFAED--HGLPLLAAHP-NLII 215 Magnetococcus m...
WP_010894666 139 ADVPAIITa-AQTSRAKLVFLCSPSNPVGAAIPLQQIETILQTla-gTALVVVDEAYGEFSDVp-SVVPLLARYP-HLVV 214 Xylella fastidiosa
WP_010895944 136 LDLLNIK---LNLSRVKLIYICNPNNPTGNIFFKKDLIFLLNItl-gQALVVIDEAYIEFSPEe-SMTNYLKDYP-NLVV 209 Buchnera aphidi...
Q58365       226 LRTFSKVFgLAGMRVGYGVANKKIIDYMMRVKPIFSLTRLSQVCAITALRDRE--FFERCVRDGIKSREMLYNGLKKFKD 303 Methanocaldococ...
P44423       221 IRTLSKAFaLAGLRCGFVLANPELIDILSKVIAPYPIPVPSADLAEQALRPSNiaTVQALTQELLSNRQWLAKALLVLHQ 300 Haemophilus inf...
P06986       209 LRTLSKAFaLAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGivAMRERVAQIIAEREYLIAALKEIPC 288 Escherichia col...
P07172       225 LQTLSKSFgLAGIRLGMTYATAELARILNAMKAPYNISSLASEYALKAVQDSNlkKMEATSKIINEEKMRLLKELTALDY 304 Saccharomyces c...
O33770       235 VRTLSKAFsLASYRLGYTIANEEIVKALMKSSTPFDIPLPSLIAGITALENPS--YIKDVVNIVNRNREILYQGLKNLN- 311 Sulfolobus solf...
P73807       202 SRTLSKSYsLAGMRVGLAIAAPALIEEMDKVRDSYNLDRLAQVLGTAALRNQA--EFVPLWEKVRHTRTRLMEQLAEL-D 278 Synechocystis s...
O06591       227 TRTMSKAFaFAGGRLGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSD--DTLSSVAALIAERERVTTSLNDMG- 303 Mycobacterium t...
WP_011715135 216 TRSASKSLsLAGMRIGIGFMHADVALQMHKVRDSYNVDRVAQAALLAAYENWS--DYAPLIARIKQQRQWTTTQLRKR-G 292 Magnetococcus m...
WP_010894666 215 LRTLSKAHaLAAVRIGSVIADAHLVAILRRCQAPYPLPTPCVSLAEQGLSAAAlqVTAQRVAEIRAERERLGAALACLSG 294 Xylella fastidiosa
WP_010895944 210 LRTLSKAFaLAGIRCGFTLAKKEIIQTLSKVISPYPISIPVSDIAIRSLEKDYvqLMKNRVLDSNNNRIWLINQLKNITC 289 Buchnera aphidi...
Q58365       304 IK-VYPS--EANYLLVELKt----mKAKEFCEELLKRGVIVRDCTSFDGLgDNYVRVSIGTFEEVERFLKILEEI 371 Methanocaldococcus j...
P44423       301 VEkVYES--EANYLLIKCQ------NGQAVFKALWEQGIILRDQNKTL-HlQNCIRITVGTRNECEKVVEAIKEV 366 Haemophilus influenz...
P06986       289 VEqVFDS--ETNYILARFK------ASSAVFKSLWDQGIILRDQNKQPSl-SGCLRITVGTREESQRVIDALRAE 354 Escherichia coli K-12
P07172       305 VDdQYVGglDANFLLIRINggdnvlAKKLYYQLATQSGVVVRFRGNELGc-SGCLRITVGTHEENTHLIKYFKET 378 Saccharomyces cerevi...
O33770       312 LK-VYKS--ITNFLLIK--------DNRNLQEMLMRHGIAIRKLY------DNFYRITIGTEDQCKMVIDKLGEE 369 Sulfolobus solfatari...
P73807       279 FQ-VCPS--DANFVFA-APrw---mAAADLYQALKEKKILVRYFN--HPRiTDYLRITVGTDGEIDQLLLAIASL 344 Synechocystis sp. PC...
O06591       304 FR-VIPS--DANFVLFGEFa-----DAPAAWRRYLEAGILIRDVGi-----PGYLRATTGLAEENDAFLRASARI 365 Mycobacterium tuberc...
WP_011715135 293 FE-VKDS--YGNFVLARVPqg--glDGLQWLESLKKRGILIRYFGSIP-QlSEFLRITIGTEEEMALLMTAIDEI 361 Magnetococcus marinus
WP_010894666 295 VRrVYPS--QGNFLLVRFD------DAEAALQALYAAGVVVRDQRAAPQl-HDALRLTVGTPEQNTRLLAVLRDI 360 Xylella fastidiosa
WP_010895944 290 VEtVFES--NANYVLVKFS------MFEKVFETLWNKGIILRNQNEKTNl-KKCIRISMGTRSESLRLIKELKIF 355 Buchnera aphidicola
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