4JJP,2I5B,4C5J


Conserved Protein Domain Family
ThiD

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COG0351: ThiD 
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis
Statistics
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PSSM-Id: 440120
Aligned: 913 rows
Threshold Bit Score: 137.092
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JJP_A        12 LTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKIGMVSSPEI 91 
WP_015260187   8 LTIAGSDPGGGAGLQADLTTFTRLGVHGATAITAITVQDTRDVADFDVLPARRLADQIEITLADLPVAAIKIGMLGSAEN 87 
WP_053820574  10 LVLSGLDPSGAAGIAADIETINQFGLTPLPIITLLTAQNTQKVESLEVTKNDLLEHQFKLIDEDIHFNTVKIGLLGSSSQ 89 
WP_122951008   6 LVLSGLDPCGGAGIVADIETINQFGLTPLPIVTTMTVQNTQFVAEVQPVDVKLMVKQFHHLQADINFKVVKIGLLSSSVQ 85 
WP_011738288   6 LVLSGLDPCGGAGLVADIESINQFGVTPLVITTNLTVQNTVSIESLVEVDCGLIVKQFKHLQADIDFKVVKIGLLSSIKQ 85 
WP_003657026  11 LCFSGLDPSGGAGIQADIESIGASGAHAAIACTALTIQNSQKVFGFEPVCHQLLKAQAQAVLDDLPVRAIKSGMMGTLEN 90 
WP_087463473  11 LILSGLDPSGGAGIQADIQTTSLLGCHPLPIVTLNTVQTTARVLQSQAVSAQFIRQQIEALQTDVRINAIKVGALGDSQI 90 
WP_011279479   6 LCFSGLDPSGGAGLQADIEAIGQAGAHAAIACTAITVQSSQQVIGFEACAADLVRDQAVAVLDDLPVNVIKSGMLGTTDN 85 
WP_005881920  14 LVFSGLDPSGGAGIGADIEAIGATGAHALSVITALTVQDNDKVYAVNSVDADIIARQADVLIQKIPVAAVKIGIVGNRAN 93 
WP_001247947   6 LCFSGLDPSGGAGLQADIEAIGQSGAHAAIACTALTIQNSQQVFGFEATSKELLLAQANAVVGDLPIKCVKSGMLGTTDN 85 
4JJP_A        92 ILEIVENLK----KY---NPKYLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIkihnVDDMKR 164
WP_015260187  88 VETVAAILA----AH---PHIPVVLDPVMVAGGGSELATRAVVDLTRERLLPRATVVTPNTPEAARLSG-----HDDARR 155
WP_053820574  90 IIAISNLIK----NR---KQLNIVLDPILISGSNENLSSIEIIEAMKAELFPLCLVLTPNLAELNALAP-----GLDEQA 157
WP_122951008  86 IKAIADLVK----GK------TIVLDPIVKASTQEVLLQTQVISTLKQDLLPLVEILTPNMAELFTLSG-----EKDEQK 150
WP_011738288  86 IKTIAKLVK----NK------TIILDPIVKSSSDCDFLDHALIDALKQYLLPLAKVITPNLSELKILAD-----EQDEQK 150
WP_003657026  91 IIALTELFE----TCt-iKHIPYVLDPVLVANSGGILGDVKTLAQAFSRLLPYATLITPNTHEIRALSG-----QQDLHD 160
WP_087463473  91 IEVVRAAAA----QL----SVPLIIDPVLRAGGGGKLFNGHRARADYEKLYPLCTLITPNSEELLELTG-----ASTIND 157
WP_011279479  86 IAMLTQLFA----DEtipEGTLFVLDPVLVANSGDSLGDEQTLVTAFRRLLPYATLITPNTHELRALSA-----EQDLHI 156
WP_005881920  94 AETIADVIRrlrqKQ---PDLPLVLDTVLGSGHGFALSDG-LPEYALSPLIGLATLITPNLPEAKRLYPR----SDDIEE 165
WP_001247947  86 IAALAEFLR----AH---PDYQYVLDPVLVANSGGSLGDQTTLVKAFVELIPLATLITPNTVELRALTG-----VTDLDQ 153
4JJP_A       165 VGEEILQLGPKFVLMKGGHL-D---------G--E-AVDILVGKNI-FKVYKSERIdKKNTHGTGCTLSSAITSYLALGY 230
WP_015260187 156 WGETLRALGARNVLITGGDA-PadaeanrqsLp-P-IVNVLYREDGhMRRFELPRL-PPSFHGSGCTLAAAIAAFLARGR 231
WP_053820574 158 AVASL---NCPWVLVTTSDS-S---------Ea-E-IEHRLYHEAKlIQKFIYDKL-PHKFHGSGCTLSSAISALIASGD 221
WP_122951008 151 AIEKL---ACKWILLTTTDV-S---------Es-S-IEHRLYHRAKlVKSYTYDKL-SGNYHGSGCTLSSAISALIASGA 214
WP_011738288 151 AIKKL---FCNWILLTKTDS-S---------Dd-V-IEHCLYRHGIlIQSFIYKKL-SGSYHGSGCTLSSVISTLIALGL 214
WP_003657026 161 AAKALNDQGANAVLVKTSHDfN---------Tg-D-IEQFLYINGRiHHTSIVPRL-TGEFHGSGCSLASHIAGRLAMGD 228
WP_087463473 158 AVVSLTASGCEHILVTGGHE-P---------Ga-E-LENRLYGQGKlIARWQWTRI-EGEFHGTGCTLAAAISAGLAKGY 224
WP_011279479 157 GAQKLCAQGTYAVLVKTSHDfD---------Sg-D-IEQYLYIEGEmVYKSTLPRL-DGEFHGSGCSLASFIAGRLAMGD 224
WP_005881920 166 QAKYLLSLGARDVLVKGGHG-N---------DvnS-VVNCWFTGNr-SKEWKWTRI-GGEFHGTGCTLASAIAGYLACGM 232
WP_001247947 154 ATQKLFEMGAKAVLVKGGHE-D---------Tp-NfIKNSLYIDGElATSSTCPRL-EGEYHGSGCSLASFIAGRLALGD 221
4JJP_A       231 EITEAVNLSKIYITEAIKRSFDI-GH----GVg-PVH---------HF 263
WP_015260187 232 DLEPAIIEAQGFMTEAIATGYAP-GR----GQhvPNRl---------C 265
WP_053820574 222 DVDVACNKALQYTYQCLLNAKKL-GK----MQfhPNRtsskli----- 259
WP_122951008 215 NIELACKNALDYTYQTLLNAKNI-GK----MQchPNRmpvknindrES 257
WP_011738288 215 SVEIACKRALDYTYQALLNAKSI-GK----MQyhPNRqspl------- 250
WP_003657026 229 DIIDAITAADAWIHQTLIHADKP-HQsd-nTQliPNRfi--------- 265
WP_087463473 225 NLIKSCKEAQTFTDKAIRNAYRI-GQ----GQsiPCRied-------- 259
WP_011279479 225 ALIDAVKAADSWITKTLRAADVP-HPedskAQliPNRf-------vRF 264
WP_005881920 233 SMEVALEKGQELTQTALAKAFSV-AD----GQkiPGRhi-----crEF 270
WP_001247947 222 SLKIAVQHAETWLFGVLKNAETPvPN----GQkiPKRf---------- 255
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