6BBJ


Conserved Protein Domain Family
TRPV4
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cd22195: TRPV4 
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4
TRPV4 is expressed broadly in neuronal and non-neuronal cells. It is activated by various stimuli, including hypo-osmolarity, warm temperature, and chemical ligands. TRPV4 acts in physiological functions such as osmoregulation and thermoregulation. It also has a role in mechanosensation in the vascular endothelium and urinary tract, and in cell barrier formation in vascular and epidermal tissues. Knockout mice studies suggested the functional importance of TRPV4 in the central nervous system, nociception, and bone formation. TRPV4 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Links
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Statistics
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PSSM-Id: 411979
Aligned: 7 rows
Threshold Bit Score: 1465.46
Created: 1-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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tetramer
Conserved site includes 68 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:All members of the TRPV channel subfamily have a basic architecture of homo- or hetero-tetrameric arrangements around a central pore. Different subunits within the TRP family are also able to form heteromeric channels, with the heteromeric channels exhibiting distinct functional properties as compared to the homomeric channels.
  • Structure:6BBJ: Xenopus tropicalis TRPV4 forms a homotetramer; contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
6BBJ_A        98 PMDSLFGYETYHHHPTENRRKRKkillekenln-sqapspdpppVIKMFNRHMLFDIVSRGSTAELEGFLPFLLAQKKRl 176
XP_005999492 101 PMDSLFDYGTYHQYPTENKRRRKriihdkqspn-qktqapnpppILKVFNRPILFDIVSRGTAAELDGLLAFLVTHKKRl 179 coelacanth
XP_007900044 106 PMDSLFDYGTYRQSSDEKRKRKKlpkdkapkv---kppapdpppVLKVFNRVLLFDIVSRGVVSELDGLLSFLLSQKKRl 182 elephant shark
BAN04747     101 PMDSLFDYGTYHHHPTENRRRRKkivtekdnqn-sqnsspdpprVIKMFNRHILFDIVSRGATSELDGFLTFLLSQKKRm 179 Japanese treefrog
AAI63540      93 PMDSMFDYGTCRQINNNKKGRRKklprgkaeigmscdegspeppVLKVFNRWMLFEAVSRADPRALDGLLQYLQSHEKRl 172 zebrafish
Q9HBA0       103 PMDSLFDYGTYRHHSSDNKRWRKkiiekqpqsp--kapapqpppILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRl 180 human
A0A1D5PXA5    89 PMDSLFDYGTYRQHPSENKRWRRrvvekpvagt--kgpapnpppILKVFNRPILFDIVSRGSPDGLEGLLSFLLTHKKRl 166 chicken

Feature 1                                                                          # #           
6BBJ_A       177 tDEEFREASTGKTCLTKALMNLnggKNDTIPMLIDIAEKtgNLREFINSPFRDVYYRGQTALHIAIERRckHYVELLVEK 256
XP_005999492 180 aDEEFREPSTGKTCLPKALLNLtngKNDTIPILVEIAEKtgNLREFINSPFRDVYYRGQTALHIAIERRckQYVELLVEK 259 coelacanth
XP_007900044 183 tDEEFREPSTGKTCLPKALLNLnngKNDAIPVLLEIAEKtgNLREFINAPFRDVYYRGQIALHIAIERRckHYVELLVEK 262 elephant shark
BAN04747     180 tDEEFREPSTGKTCLPKALLNLnggKNDTIPMLIDIAEKtgNLREFLNSPFRDVYYRGQTALHIAIERRckHYVELLVEK 259 Japanese treefrog
AAI63540     173 tDEEFKELSTGKTCLPKALLNLhngQNDTIPILVDIAEQtgNLREFINTPFRDVYYRGQMALHIAIERRckQYVELLVEK 252 zebrafish
Q9HBA0       181 tDEEFREPSTGKTCLPKALLNLsngRNDTIPVLLDIAERtgNMREFINSPFRDIYYRGQTALHIAIERRckHYVELLVAQ 260 human
A0A1D5PXA5   167 tDEEFREPSTGKTCLPKALLNLsagRNDTIPILLDIAEKtgNMREFINSPFRDVYYRGQTALHIAIERRckHYVELLVEK 246 chicken

Feature 1                   ##       ## #         #                                    #      #  
6BBJ_A       257 gadvHAQARGRFFQPKDegGYFYFGELPLSLAACTNqPDIVHYLTENAHKKADIRRQdsRGNTVLHALVAIADntreNTK 336
XP_005999492 260 gadvHAQARGRFFQPRDegGYFYFGELPLSLAACTNqPDIVHYLIENAHKKADLRRQdsRGNTVLHALVAIADntreNTK 339 coelacanth
XP_007900044 263 evdvHAQARGKFFQPKDegGYFYFGELPLSLAACTNqPDIVHYLTENPHKVADLRRQdsRGNTVLHALVAIADntreNTK 342 elephant shark
BAN04747     260 gadvHAQARGRFFQPKDegGYFYFGELPLSLAACTNqPDIVHYLTENAHKKADLRRQdsRGNTVLHALVAIADntreNTK 339 Japanese treefrog
AAI63540     253 gadvHAQARGRFFQPRDegGYFYFGELPLSLAACTNqPDMVHYLTENGHKKADLRRQdsRGNTVLHALVHIADntrdNTR 332 zebrafish
Q9HBA0       261 gadvHAQARGRFFQPKDegGYFYFGELPLSLAACTNqPHIVNYLTENPHKKADMRRQdsRGNTVLHALVAIADntreNTK 340 human
A0A1D5PXA5   247 gadvHAQARGRFFQPKDegGYFYFGELPLSLAACTNqPHIVHYLTENGHKQADLRRQdsRGNTVLHALVAIADntreNTK 326 chicken

Feature 1        #                                                                   # ####      
6BBJ_A       337 FVTKVYDLLVIKCvklypdsslEAIFNNDSMSPLMMAAKLgKIGIFQHIIRLEIKDeearhlsRKFRDWAYGPVYSSLYD 416
XP_005999492 340 FVTKMYDMLLIKCaklfpecnlEAILNNDGMSPLMMAAKLgKIGIFKYIIRREVMDenarhlsRKFKDWAYGPVYSSLYD 419 coelacanth
XP_007900044 343 FLTKMYDLLLIKCaklypdcnlEVILNNDGLSPLKMAAKLgKIGIFQHIIRREIKDesarhfsRKFRDWAYGPVSSSLYD 422 elephant shark
BAN04747     340 FVTKMYDLMVIKCanlypdcslEAILNNDGMSPLMMAAKLgKIGIFQHIIRLEIKAeeaghlsRKFRDWAYGPVYSSLYD 419 Japanese treefrog
AAI63540     333 FVTKMFDLLLIKCaklypdcnlENILNNDGMSPLMMAAKLgKIGVFQHIIRREIKDeearhlsRKFKDWAYGPVYSNLYD 412 zebrafish
Q9HBA0       341 FVTKMYDLLLLKCarlfpdsnlEAVLNNDGLSPLMMAAKTgKIGIFQHIIRREVTDedtrhlsRKFKDWAYGPVYSSLYD 420 human
A0A1D5PXA5   327 FVTKMYDLLLIKCaklfpdtnlEALLNNDGLSPLMMAAKTgKIGIFQHIIRREIADedvrhlsRKFKDWAYGPVYSSLYD 406 chicken

Feature 1                                                                             #          
6BBJ_A       417 LSmLDTCGEEVsVLEILVYNSkvenrhemlavEPINELLRDKWQKfgAVSFYISVVSYLIAMIIFTLIAYYRpmdgtppy 496
XP_005999492 420 LSsLDTCGMEVsVLEILVYNSrienrhemlavEPINELLRDKWRKfgAVSFYISVVSYLVAMVIFTLIAYYRpvegrppy 499 coelacanth
XP_007900044 423 LSaIDTCGEEVsLLEILVYNGkienryemlavEPINELLRDKWKKfaAVSFYLSVISYLTAMVIFTLIAYYRpsdgkppy 502 elephant shark
BAN04747     420 LSsLDTCGEEVsVLEILVYNSkvenrhemlavEPINELLRDKWRKfgAVSFYISVVSYLIAMIIFTLIAYYRpmegtpph 499 Japanese treefrog
AAI63540     413 LSsLDTCGEEVsVLEILVYNSkienrhemlavEPINELLRAKWQKfaAVTFYISVFSYLVTMIIFTLVAYYRpsvgkppy 492 zebrafish
Q9HBA0       421 LSsLDTCGEEAsVLEILVYNSkienrhemlavEPINELLRDKWRKfgAVSFYINVVSYLCAMVIFTLTAYYQplegtppy 500 human
A0A1D5PXA5   407 LSsLDTCGEEVsVLEILVYNSkienrhemlavEPINELLRDKWRKfgAVSFYISVVSYLCAMIIFTLIAYYRpmegpppy 486 chicken

Feature 1                                                       #  ##  #                 # # # ##
6BBJ_A       497 pyrtTMDYMRLAGEIVTLLTGVVFFITNIKDLFMKKCPGVNSLFIDGSfQLLYFIYSVLVIITAVLYLVgieSYLAVMVF 576
XP_005999492 500 pyktTIDYLRLAGEVITLLTGIFFFFTNIKDLFLKKCPGVNSLLIDGSfQLLYFIYSVLVLVTAALYLTgieAYVAVMVF 579 coelacanth
XP_007900044 503 pyntTADFMRMGGEIITVVTAIFFFFTNVKDLFLKKCPGVNSMFIDGSfQLLYFIYSILVLVSAGLYLAgeeSYLGVMVF 582 elephant shark
BAN04747     500 pyrtTVDYLRLSGEIITLVTGIFFFLSNIKDLFMKKCPGVNSLFIDGSfQLLYFIYSVLIIITAALYLTgveAYLAVMVF 579 Japanese treefrog
AAI63540     493 aydtTEDKVRLAGEIITVGSGLFFFVTNIKDLFLKKCPGVNSIFVDGSfQLLYFIYSVLVLVSAALYLSgieAYVSVMVF 572 zebrafish
Q9HBA0       501 pyrtTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSfQLLYFIYSVLVIVSAALYLAgieAYLAVMVF 580 human
A0A1D5PXA5   487 pyttTIDYLRLAGEIITLLTGILFFFSNIKDLFMKKCPGVNSFFIDGSfQLLYFIYSVLVIVTAGLYLGgveAYLAVMVF 566 chicken

Feature 1          ##  #              ##  #   #   #     #   #   #  #  ##                         
6BBJ_A       577 ALVLGWMNALyftrglkLTGTYSIMLQKILFkdLFRFLLVYLLFMIGYASALVSLLNPCTsqesciet----ssnctvpe 652
XP_005999492 580 ALVLGWMNTLyftrglkLTGTYSIMLQKILFkdLFRFLLVYVLFMIGYASALVSLLNPCLttetctan----nasctape 655 coelacanth
XP_007900044 583 ALVLGWINTMyftrglkLTGTYSIMIQKILVkdLFRFLLVYLLFMIGFTSALVSLLVTCPinefeicditsdspnctsst 662 elephant shark
BAN04747     580 ALVLGWMNALyftrglkLTGTYSIMLQKILFkdLFRFLLVYLLFMIGYASALVSLLNPCSteeicknn----gtdcsvpe 655 Japanese treefrog
AAI63540     573 ALTLGWMNTLyftrglkLTGTYSIMIQKILIkdLFRFLLVYVLFMIGYASALVSLLTICPdkdtck---------encpt 643 zebrafish
Q9HBA0       581 ALVLGWMNALyftrglkLTGTYSIMIQKILFkdLFRFLLVYLLFMIGYASALVSLLNPCAnmkvcned----qtnctvpt 656 human
A0A1D5PXA5   567 ALVLGWMNALyftrglkLTGTYSIMIQKILFkdLFRFLLVYLLFMIGYASALVSLLNPCPssescsed----hsnctlpt 642 chicken

Feature 1                      #  ##  # #        #   # ### ###    # ## ###  #  ## ### #          
6BBJ_A       653 YPSCRDSSTFSKFLLDLFKLTIGMGDlem-inSAKYPAVFIILLVTYIILTFVLLLNMLIALMGETVGQVskESKQIWKL 731
XP_005999492 656 YPYCRDSNTFGKFIMDLFKLTIGMGDlem-vnSAKYPGVFIILLVTYIILTFVLLLNMLIALMGETVGQVskESKQIWKL 734 coelacanth
XP_007900044 663 YPICRDNLSFSKFLLELFRLTIGMGDldv-inSAKFPIVFVILLVSYIILTFVLLLNMLIALMGETVGQVskKSKQIWKL 741 elephant shark
BAN04747     656 YPSCRDSSTFSKFLLDLFKLTIGMGDlem-inSAKYPAVFIILLVTYIILTFVLLLNMLIALMGETVGQVskESKQIWKL 734 Japanese treefrog
AAI63540     644 YPECRDTNTFSEFLLDLFKLTIGIGDldnmlkGAQYPAVFLILLVTYIILTFVLLLNMLIALMGETVGQVskESKKIWKL 723 zebrafish
Q9HBA0       657 YPSCRDSETFSTFLLDLFKLTIGMGDlem-lsSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVskESKHIWKL 735 human
A0A1D5PXA5   643 YPSCRDSQTFSTFLLDLFKLTIGMGDlem-leSAKYPGVFIILLVTYIILTFVLLLNMLIALMGETVGQVskESKHIWKL 721 chicken

Feature 1                                                         #  #                           
6BBJ_A       732 QWATTILDIERSFPVCMRKafrsGEMVTVGKnldgtpDRRWCFRVDEVNWSHWNQNLGIINEDPGRNDgyqyygf-sqtv 810
XP_005999492 735 QWATTILDIERSFPVFLRRvfrsGEMVTVGKnldgtpDRRWCFRVDEVNWSHWNQNLGIINEDPGKNEtyqyygf-shtm 813 coelacanth
XP_007900044 742 QWATTILDVERSFPICLRKafrsGEMVTVGInsdgtpDRRWCFRVDEVNWSHWNQNVGIINEDPGRNDiyqfdgginqtm 821 elephant shark
BAN04747     735 QWATTILDIERSFPVFIRKafrsGEMVTVGKnldgtpDRRWCFRVDEVNWSHWNQNLGIINEDPGKYDtyqyygf-sqtv 813 Japanese treefrog
AAI63540     724 QWATTILDIERSFPVCLRRsfrvGEMVTVGKgldgkpDKRWCFRVDEVKWSHWNQNLGIINEDPGQKDlseht----qgg 799 zebrafish
Q9HBA0       736 QWATTILDIERSFPVFLRKafrsGEMVTVGKssdgtpDRRWCFRVDEVNWSHWNQNLGIINEDPGKNEtyqyygf-shtv 814 human
A0A1D5PXA5   722 QWATTILDIERSFPLFLRRvfrsGEMVTVGKgtdgtpDRRWCFRVDEVNWSHWNQNLGIISEDPGKSDtyqyygf-shtv 800 chicken

Feature 1                            
6BBJ_A       811 grLRRDRWSVVVPRVVELNK 830
XP_005999492 814 grLRRDRWSTVVPRVVELNK 833 coelacanth
XP_007900044 822 grLRRDRWSTVVPRVVELNK 841 elephant shark
BAN04747     814 rhLRRDRWSVVAPRVVELNK 833 Japanese treefrog
AAI63540     800 rgLRRDRWSTVVPRVVELNR 819 zebrafish
Q9HBA0       815 grLRRDRWSSVVPRVVELNK 834 human
A0A1D5PXA5   801 grLRRDRWSTVVPRVVELNK 820 chicken

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