1GG4,4CVK,4QDI,3ZM5


Conserved Protein Domain Family
MurF

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COG0770: MurF 
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]
UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Statistics
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PSSM-Id: 440533
Aligned: 835 rows
Threshold Bit Score: 275.057
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GG4_A         2 I---SVTL---SQLTDILNG-ELQG---A-DITLDAVTTDTR-KL-T--PGCLFVALKGERFDAHDFADQAKAGGAGALL 66 
WP_069799879   1 M---NYTT---KEIAEITQS-Q-Ii--gDkNLQIHHIAFDSR-NI-YstLKTAFIAINTHKNSGEKYIPQAIEKGIKVII 68 
YP_011720      1 ---mQLTP---NEMRESLGAgAILGaq--gDATFAAVRSDSR-KV-A--PGDLFVCIRGERFDGHDFAADVVRQGARVLI 68 
WP_013925521   1 --meCFDLrswPFFAQA-GG-DA-----HsPAVIKHISIDSR-RIfS--PSTLFVALKGQAHDGHAFVAEAAKSGAKYAL 68 
WP_013515678   1 ---mKLTL---GDVQHCLTG--M-AeecReFAVINAVRTDSR-AV-E--PGDLFFCIEGWNFDGHEFAAQAETRGAVAVV 67 
WP_024563853   1 M---KYTA---QELASMTNS-R-It--gNkNEVVEQLIFDSR-LI-FssKNNAFIALKTQKNNGSKYIKEAIEKGIKVII 68 
WP_111336776   2 TnspKLSL---ETIAQLSQG-ELRCe--DsALLISEISTDSRgAF-A--RHSLFIALTGEHFDGHEFVENAYKKGAAAAM 72 
WP_015774776   1 ---mNMTL---TQIASAMAS-SIe---qDhDLTVGRVCIDSR-AV-R--KGDLFFCIVGQKLDGHEFARQAVENGACAVV 66 
WP_014937731   1 M---NYTA---RQIAEITGA-K-Li--gAgDKIIKHFAFDSR-II-YspKNTGFVAIKTKKNNGEKYIASAVEKGIELIV 68 
WP_059061192   1 --mdAFDLrlwNGFNQA-GG-TL-----SePAIVDQITIDSR-RIgS--SHSLFVALKGEKLDGHDYVRQAVQAGAKYAI 68 
1GG4_A        67 VSR-P------L-Di------DLPQLIVKDTRLAFGELAAWVRQQ-VPARVVALTGSSGKTSVKEXTAAILSQCGNTLYT 131
WP_069799879  69 SEN-F------Y-Sey----dGITWIIVENSVKFLQDLAHYHIEN-HSIKTIGITGSNGKTIVKEWLYQCLWNEFPTVKS 135
YP_011720     69 AER-Dp------fNgec-psaDVTIMVVDDSVKALGRLANLHRMR-SKARVVGVTGTAGKTTVKELLAQVLGVRGDTARN 139
WP_013925521  69 VHQ-DwqppypLk--------DIILLRVNDPLKAFQALAKAYRQErTQCKVVAIGGSYGKTMLKDLLETMLAKRYKVMAS 139
WP_013515678  68 ASRmP--------Eg-----vTVPVIMVRDTVRALGQLASCWRDL-CGSILVAVTGTAGKTTVKEMLAAVVSRKFTVAKN 133
WP_024563853  69 ADE-I------YeFsg----qDITWIITSDTQNFLRQLAHHHLQN-LNIKTIGITGSNGKTIVKEWLYQCLWDEMRTVKS 136
WP_111336776  73 VSR-S------A-DidslaipGMALIIVDDTLGALQRLAAGWRAL-FDIPVVGITGSNGKTVVKDMLANMLAQEHTVYRS 143
WP_015774776  67 ASA-P------L-Dl------DVPVLLVRDTTSALGRLARAWREK-TRARVIGVSGSAGKTTVKEMLAQVLSAAGRTAKN 131
WP_014937731  69 SEH-K------T-Ldn----eHLSWLIVDDTVKFLQKLAHLHLKS-HNIQTIGITGSNGKTIIKEWLYQCLSEDIRCVKS 135
WP_059061192  69 VSD-QwtppsdLn--------GLTLLRVKSPLKAFQEIAKAYRLQ-LPVKIIGVTGSFGKTMVKDLLHTLLATEKKTAAS 138
1GG4_A       132 AGNLNNDIGVPXTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPE 211
WP_069799879 136 PKSFNSQIGLPISLLQTSEKHQVGIFEVGISKPQEMKTLEEIFSPKIGILTHIGTAHSSNFENELQLIKEKLILFKNS-- 213
YP_011720    140 PLNLNNQIGLPLSMLEATGNESFWVMEAGISQPQDMDELGAVLRPDIGLVLNVGQGHVAGLGD-RGVAYYKSRLLAHLAE 218
WP_013925521 140 PESFNSQIGVPLSLFKIKDSHEIALVEAAFSEPGEMEVLADIIMPEHVILTSIGAKHLHTLGSLETTALEMVKLLQPLKK 219
WP_013515678 134 YRNLNNQIGLPVSMLKADSGQEVWIMELGISVKGDMEELAVIASPDVAVITNVGPGHLEGLGDVAGVARAKSSLLKYMRQ 213
WP_024563853 137 PKSYNSQIGLPISILQANNDDELGIFEVGISKPHEMEKQSEVFSPQIGVFTHLGSAHSEYFENEEQLLNEKLKLFEKS-- 214
WP_111336776 144 PGSYNSQVGVAISLLGIRPEHEIAIIEAGISRVGEMARLEKMVRPTLGIITNIGLAHAAGLGDLETTAAEKVKLFEGLG- 222
WP_015774776 132 FRNLNNQIGLPLSILEMDGDEDFWVLELGISRPGDMDELGYILAPDAALLVNIGACHLEGLGSLAGVAEQKAVLLDHVRK 211
WP_014937731 136 PKSFNSQIGLPLSLLNIRPEHKVGIFEVGISEPNEMEVLETIFSPKIGVLTHIGSAHISNFKSEEHLIDEKISLFKDS-- 213
WP_059061192 139 PESFNSQIGVPLSLLTIRKEHEIAIIEAAISQKQEMEALADLIKPDYTILTPIGKKHLATLQDMSTLAQETLKLIWATPE 218
1GG4_A       212 NGIAIXNA--------DNN-DWLNWQSVI-GS-RkVWRF-SPNaANS-D--F-TAT------NI-HVT-SH-G-TEFTLQ 265
WP_069799879 214 -EIIIYNG--------DNE-QVCKEIKTQySDkK-LISF-GLK-THN-D--V-KII------CN-YND-RN-Q-E-ILVQ 265
YP_011720    219 GGTGLVCA--------DYD-DLVREARSV-CR-R-LQFF-SASgRGV-G--Y-RAAydgpvaDAaGSDgGV-R-GRYRVW 279
WP_013925521 220 DNWALIP---------STPlFGPHLQERT-S--R-CL-Fw--T-Q-P-DsrLpHAI------SA-STTp-QmT-LPYSVH 271
WP_013515678 214 DGTAIVSK--------DYP-ELWAAATEL-TG-S-PVGF-STSdESA-S--C-HAV------FL-GAD-DD-GrGRFRLR 267
WP_024563853 215 -EVIIYNG--------DHP-LVKSKIQSLyNNkT-LISY-GLD-ISN-D--I--LI------ES-PID-QK-E-A-FNIK 265
WP_111336776 223 DGVLIFPE--------DCP-PLDPL-E-L-PG-R-QLSF-SSD-TEAsD----AAY------SI-VASrDS-G-HGFDFE 273
WP_015774776 212 GGFACVNA--------DYP-ELMQESTKR-SP-K-LVTFsGTG-ARA-D--Y-SCL------RQ-E-NvAG-A-ISYTFR 264
WP_014937731 214 -ENIIFNG--------DNT-LVNNKINTLySSkN-LISY-GFN-KDN-N--I-HIS------SN-WKD-RQ-Q-P-ITVQ 265
WP_059061192 219 GGWSLLPTevhsqlsqSTPsFPIY--------------Fw--D-E-A-CqkLpHAT------SF-QTDv-TvP-AHYQLS 270
1GG4_A       266 T--PT-GSVDVL--LPLPGRHNIANALAAAALSXSVGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSX 340
WP_069799879 266 Y--FS-EKLSFP--ANQRDEATLTNALAVICILKEFGFTNEKIVEKINNLKAVEMRLESVNGVRNNLIINDSFNLDLDSL 340
YP_011720    280 L--DG-SVHEVV--APFRGAFGAENVAAVAAAAHLCGLSGEEIAAGLAEAVLPRQRFACATV-GGFVCIDDTYNANPLSS 353
WP_013925521 272 F--PD-QYL-FQgeMTKGFSYSLDLINTACKSAWLFDLPSHTISEVLQTYQFEPMRTEIWKAPTGMLFINDPYSSDPQSM 347
WP_013515678 268 T--PT-GQGEFT--APFCGDHYAENVACVAAAANALGLPFDDIVAGVQAVEADCQRFCCRPM-GDALVIDDTYNANPLSM 341
WP_024563853 266 L--LD-GYIQIP--FTNRDQATLHNALAVIAVLNFLKISHSKIVDKINNLQAVEMRMESIKGERDNLIINDSYNLDLDSL 340
WP_111336776 274 AqlEErGVHPFQ--LHVLGRHNLSNAMAAIAAADQLGLDVESMRRGLAAFELSPLRLEMHTTQSGITFINDAYNSDPTSA 351
WP_015774776 265 V--GH-EELRCT--VS-AGIHVAENLAAVVAMAMELGMTFATIESALSAYSPVAQRFVQTRV-GTWLFIDDTYNANPVSM 337
WP_014937731 266 C--FD-KSFSFP--AQQRDEATLSNVLAIIAVMHLLGFSTEKMIEKINNLKAVEMRLESVNGIKNNLIINDSFNLDLDSL 340
WP_059061192 271 F--PD-HSV-YQgrMSAAYTYYLNLINMSSKAAWLSGISASNIQQVFQTYQPEPTRTEIWKVPTGATFINDTYCSDPQSV 346
1GG4_A       341 TAAVQVLAEXP--GYRVLVVGDXAELGAESEACHVQVGEAAKAAGIDRVLSVGKQ-SHAISTA-----S---GVGEHFAD 409
WP_069799879 341 IIAYQFINQYn-rDEKTLILSDIFDVKNDDVSLYHKVAEITNQQNFKQIFLVGNQ-ISRFQEKf-------nAKTYTFST 411
YP_011720    354 ARMVEAVTEMAagGPLVFVLGEMLELGEEAADAHERLGRQLATTGARAVFWKGGN-AEAVAMGlr-lgGy-gGLFCAVDD 430
WP_013925521 348 DQALTRLQYLAsnEKKTLIFGGLKGISDQRENEYRRIGLAIAQSHIQHLMLIGp--LSDFQSLvskl--lphTTISFYPT 423
WP_013515678 342 GRSIRTAVAMAkdRPLVLVLGDMRELGDEAQARHEELGRLIRDVAPRAVFFKGAH-CGDVLCGld--gGv---DFTAVEG 415
WP_024563853 341 KIALSTLNQYGnkSQKVLVLTDIHDVKDHSEHLYHIVADLVNEHSLGKIYLIGTE-ITKFANLf-------nSRTFTFDN 412
WP_111336776 352 RAALSVLKDYAgsARSVAILGDMLDLGSRAKAAHAQLGRIVNDTGVDLLICVGAL-AEVVGESav-aaGlppEAVVFIDS 429
WP_015774776 338 ARSIGEAKRLGegKRLVLVLGDMLELGRDSVRAHRELGGLIADTGASHCFFQGRY-AEDVKDGlgdynGi----FMKVSG 412
WP_014937731 341 KIAFEFIKSYq-kPKKSLIITDFTE-KSDADNLYQEVASLINEQNFNKVFLIGEE-ISQYQHLl-------nTESFSFNT 410
WP_059061192 347 DLALRHFDYAAdsQRKIVVFGGMRGEPMHANSDYRSIGKTLAKAHLRHLLLFGTKpFKPLIEEmekn--sseTEILAFES 424
1GG4_A       410 KTALITRLkLLIAEQQVitILVKGSRSAAXEEVVRALQEN-GT 451
WP_069799879 412 TKELLESQqLNSIENQL--ILLKGARIFEFEKIKSHLELqkhd 452
YP_011720    431 TASFVDRFaSLGLASAH--VLFKGSRGNRLEVLRAAFGDAf-A 470
WP_013925521 424 IAHALRHLrEVEDPRQV--VLIKGAQKVPLDFLTETY-NDsic 463
WP_013515678 416 PGEFLAAWrDMELADAV--VLVKGSRSLKMEAFAAALCREl-D 455
WP_024563853 413 IQELIEDQeFNSIENSL--ILLKGARKFELENLKKELELqshd 453
WP_111336776 430 IDGLDSVLdDQLVAGDV--VLFKASRNIGLERAAERLLEsvap 470
WP_015774776 413 AEEVLQALnAVRRDQGV--MLFKGSRGCKMEQYYSALERSwA- 452
WP_014937731 411 TNDLFSNQeFKDLENEL--ILLKGARKFEIEQVKTYLELQkhd 451
WP_059061192 425 EKEVLEHLqNHIQSQDL--ILLKGEKKFPLDRLTEAF-NEsqn 464
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