Conserved Protein Domain Family
RE_HpaII

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pfam09561: RE_HpaII 
HpaII restriction endonuclease
This family includes the HpaII (recognizes and cleaves C^CGG) restriction endonuclease.
Statistics
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PSSM-Id: 430689
Aligned: 20 rows
Threshold Bit Score: 342.318
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX60762                 2 GEIYAFFRLLADGSVYMGTPQVQKDMNRCWPVAL-VQREEHDGTRRYYIEEDe-iRMVSGEVDRSgqfvpkeeaesVTFP 79 
CCG52267                10 SEVYTLLKVISDKQLFAGDSNLNKIETLIFPIIK-VLRDETNGTFEFSYDND---LVIVKNGEEE-----------IRIS 74 
CDA44980                11 SEIYTLFKLLGEGKVHAGDADMNKLE-LYYPILN-VIREESKK-YEYKPNVDqhiVVIDEDGNEF-----------ARIS 76 
SLUandSVAtrep:TPE_0407  14 SEIYVLLRLLADGKIYAADSELNKLKDVYFPIIK-IIREENKGEIKEYSTGEivaIYINGSKVK-------------ELP 79 
ASGPB:SGRA_2429         10 SEIYTLLKLISDGVLPQGDAHLVATD--FEYIVEaVYRSEKDGLKEYHINSDqksVLLIDGEEQ------------VEIP 75 
CDE41472                11 SELYALLKLLADGRLYCGDASQNRQDDRFFPILK-IFRNDQIDRTAYTVNAAkkeILVSRTNDCT-----------IDVS 78 
jgi:Ftrac_0428          10 SELYVFFQLLSEGKLYSADEKLERNGN-FVEVQS-IKRNDFGKPKDYKIETSgnvNIVDSETGNIl----------RAIP 77 
BAK56574                10 NEFYALLYLLENNNISIVDSDLCVIDSAIFFINKlVTQGETS--LTYQKVDDeiiIFKNTQKIGV-------------VS 74 
jgi:Cyast_0446         309 TERYSFFKIINDQRINLADKTLQKNNS-YFNVTK-ISTLNLD--ENIILVDKdsiIVENKITKSKk---------eINIS 375
Q30PG8                 311 SELFAFIKILLEQKLLLSDKELNPTGD-FFKINK-ITTENLD--LEFIPVSDfkiKSIHTKTKEEa---------eIDIS 377 Sulfu...
CCX60762                80 RADFGEAADYVLDIL--KHS-SGEEVEVpDGLEGFLDAV-RIYDLEAKT-DDRTDFKIAFWQKD---APLTGFCVRCRLS 151
CCG52267                75 VLEFQKQAHFLLTKL--KEK-TNATFSI-PEIESFINSF-DSHSLKAKS-SVKSDIRIVIHDLRtgtNPELGFSIKSQLG 148
CDA44980                77 MNKFLEESSKLLTEI--KAA-NDPAFEI-PATESFMTEI-GCSKLKAPS-KDKADIHIVIHDLRtnmTPLLGFSIKSQLG 150
SLUandSVAtrep:TPE_0407  80 ATEFEMQSELLLNEI--NSKiSKGAFSV-EKTQNFMDKI-LCYKLSAPA-TDKSDITIKIIDINtgySPTVGFSIKSELG 154
ASGPB:SGRA_2429         76 LEEFEAIKTVVLDGI--RQA-PKGTFLI-EEAIPFLSTI-HCLSLKAKS-SSKKDIEVLIYDYRvarSSKLGFSIKSQLG 149
CDE41472                79 QEEMQTKAHSILNVI--KT--HTGTFDI-PEIHNFLERI-DCKTIKAKS-TDKADIRIVIHDLNtgsKPELGYSIKSKLG 151
jgi:Ftrac_0428          78 RAEIVDITRNLIREL--KQG-KGKAFGVsSSLEANINSF-MIEKVSESY-GLKGDINLYIYDPVnsiLTDQKFSIKSLLG 152
BAK56574                75 LDAVIKAKEFLLKTLinKKPlNGGSIKL-PSLNEFIENFtDGYSIKGKA-KSKADLGANVKDNKickDVNITYSLKSQFG 152
jgi:Cyast_0446         376 ELINQNVLDNLVNQI--KD--NKGTFEI-NEMIAIQNKL-GISIIKGGQsNQKSDVILDI-NKDhffKVNEGFGIKSYLG 448
Q30PG8                 378 SIITDETLTNILNQI--KA--GSGTFEI-NDFEIIQTAL-GFSIVKGGNsSQKADIVLDI-EHNtfvKENEGFGIKSYLG 450 Sulfu...
CCX60762               152 PMNPLLDGGR-TANLKLEQTGVkf-aVPTVNKVNALP--ESPNEVAERMLMIERLGGVLKYSDVADRVFRCNLLMIDLHF 227
CCG52267               149 GASTLLNAGK-TTNFIFKIQNL----TLTQNQISEINaiETRSKIKDRIEKISEFGGSLEFQKTESSIFGNNLILIDSAL 223
CDA44980               151 SASTLLNAGT-TTNITYKVIGTe----lSDEDIEEVNsiKGHLP---RMQAILDKGCNLKYSDIEHTIFKNNLLFLDSCM 222
SLUandSVAtrep:TPE_0407 155 SSPTLLNAGK-TTNFIYKIIHGypdlVREANEIYIVSagKNHTDVRGRINKIIDENGQLKYWKMNNQTFRDNLVLIDSNM 233
ASGPB:SGRA_2429        150 NPSTLLNASK-ATNFQFWL--------PQEVNAESINkiSTSSKIKKRIEAIYEEVGQLVFTTIQNQTFANNLCLIDSAL 220
CDE41472               152 GNSTLINANKdSTNFIYQVINV------DHSQMSEFNklGK---FGAKFNYLEEIGAKLSFIGTARKETHNNLTLLDLGL 222
jgi:Ftrac_0428         153 SNPTAFNANP-TTNIIYEILTKdg-kPLEENEIIEINeiDTRHKYIDRVRFILD-NYSIHYRDYQGEVFKLNLQLIDSSL 229
BAK56574               153 SPATLLNASK-HTNFMHKVQGF------DKDKMQEVNriKTKKKLLDRIYKIKELEGKIEFYKIVSNTLERNIRLIDSSM 225
jgi:Cyast_0446         449 NKPTLLNASG-NTNFIFRVNNL------SSYSLDEINniK---KLKDRINKIINLGGIFSFYKIEKETMAYNLRIIDSMM 518
Q30PG8                 451 SKPTLLNASG-NTNFMFEIDGL------DNSKISEINqiSTATKLRDRIVAINKNGGTFRYLKAEKDTMNYNLKMVDNVL 523 Sulfu...
CCX60762               228 PRMLAEMVRLMHL--EGITRVSELTERIKE-LNPLKIKdeLIQKHGFYEYKMKQFLLALALGMRPAKIFRGTDSAVEGML 304
CCG52267               224 PKIIAESLKLFYT--STFSTTIELTNQIST-TNPLDYN--LETNHPFYSYKIKRFLTDIALGMMPSKVWTGELDATGGYL 298
CDA44980               223 PQFVADCLLINSLp-SSKSSIKECVAEIAK-RNPFNFN--GKNIEAFYAHKMKVLLLDAALGMTPAKEWTGRYDANGGYL 298
SLUandSVAtrep:TPE_0407 234 DKIIAETLLYFYR--DGISNCDEMVEKLER-ENPMNYG--NVNA---YRYKFKKFLTAVALGMKPATVWDGVDEATGGYI 305
ASGPB:SGRA_2429        221 PQIIAALLLIYYSgrAKSSKITDLVEQLRI-ENPLGFP--EIEGQHFYEYKIKRFLTDVALGMTPNTVWDGRFDAGGGYI 297
CDE41472               223 ERILADELLLYYS--TNLSSLEEITRQETN-DDPLILT--QNTTQPMYEYKIKQFLLAFALGMTCSKPWHGTFNANGGYI 297
jgi:Ftrac_0428         230 PEIIASAVLNKYA--FGITKFNEVIEKLND-ANPCNYN--LKHGHSFYEYRLINFMVESSLGMTSATVWSGEYDVIGGII 304
BAK56574               226 DKLLANALLYSYV--ENEKDLQKAFLKSNH-----------GNDEVFLRKKLIDFLYGICFGFFPSEEWDGKYSVNGGIM 292
jgi:Cyast_0446         519 PNLLAEMLLEFFV--HRNNLISE--NLLTIyQKQLAQT--MIDDLPSLTIKLKRFLVGVLLGFFAETKWDGKY-SSNGTI 591
Q30PG8                 524 PEIIGYLLMAFYG--NRISNLSDIVNYLCDyTDILTHL--DIDDKAMLINKLKKFLVDILLGFFAGEKWNGSY-ASNGTI 598 Sulfu...
CCX60762               305 LVDGQGEVLC----YHQSCRQDFAEFLYQNTRFEKGALEKDKYGFLERE-NGSWYFKLNVKIGL 363
CCG52267               299 VVKENGEVLC----YHIYNRNEFEDYLYSNTKLETASSTRHEFGKVYEE-NGQLYFKLNLQIRF 357
CDA44980               299 VVRKDGEIVC----YHFYNRNDVEDYLYNNTRFERASRSRYGFGYVYREkDGCIYIKLNLQIRF 358
SLUandSVAtrep:TPE_0407 306 VVTKEGYVLA----YHIYNRNYFEEYLLKNTKYETASTSRHDFGEIYSE-NGKDFINLNLQVRF 364
ASGPB:SGRA_2429        298 VVRNDGELVC----YHIYDRNQFEDYLFHNTKLDTPSSSRHGFGLIYRE-GGENYFNLNIQIRF 356
CDE41472               298 VIKEDGDIIC----YHFFDRNDLENYLFYNTKFDTPSTSRHLFGKIYEQ-GGHFFIKLNLQVRF 356
jgi:Ftrac_0428         305 IVKGNEEVVS----YHLIDFNKFKKYLLDNCRLDNPSGSKMGYGTAYIE-EGKSYIKLNFQVKv 363
BAK56574               293 VTKNSGEVVLldkiYH---NEILENYLYYKSKFDSPSTSRYHMLEIFED-SGDFFFTLNLQIRs 352
jgi:Cyast_0446         592 VVKENGEQLA----FHIIDIVSLEDYLFENIVFDTPSTTRHRYGKLILEnDGCLYFKLNLQLRF 651
Q30PG8                 599 VVKENGDLIT----FHIINMENLKNYLFENIKLDTPSTSRHKFGTIIQD-KTKNYFKLNLQLRF 657 Sulfurimonas denitrif...
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