Conserved Protein Domain Family
7tmA_SSTR5

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cd15974: 7tmA_SSTR5 
somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.
Statistics
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PSSM-Id: 320640
Aligned: 6 rows
Threshold Bit Score: 466.2
Created: 6-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #  ##           ###### ##
AAX55630      34 VLIPIFYILVCAVGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADVLFMLGLPFLATQNAISyWPFGsflCRLVMTVDG 113 chicken
P35346        41 VLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASfWPFGpvlCRLVMTLDG 120 human
AAH68356      35 KALAVIYLVVFIVGLTGNSLAIFVVLRYTKMKTVTNMYILNLAVADELYILGLPFLTTHNVLSyWPFGnflCRILMWADS 114 zebrafish
XP_006011391 103 VLIPVVYFLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYIVNLAVADELFMLGLPFLATQNAISyWPFGsflCRLVMTVDG 182 coelacanth
XP_002932329  44 FIIPLIYLLVCVIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADVLFMLGLPFLATQNAISyWPFGtflCRLVMTVDG 123 western clawed ...
XP_007901730  44 LLISVIYLIVCAIGLSGNSLVIYVVLRYAKMKTVTNVYILNLAVADELFMLGLPFLATQVALSyWPFGsfmCRLVLTVDG 123 elephant shark
Feature 1          #                                            # #####                        # 
AAX55630     114 INQFTSIFCLTVMSMDRYLAVVHPIKSTKWRRPRVAKLISMTVWTFSFLVVLPVFIFSDvqedFHTCNMNWPEPvnIWSA 193 chicken
P35346       121 VNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADvq-eGGTCNASWPEPvgLWGA 199 human
AAH68356     115 ISQFTSTFCLTVMSIDRYMAVVHPIRSARWRRPSVAKVINSMVWALSCLLTLPVIIYCDvqpgLNTCNLSWPEPrdVWST 194 zebrafish
XP_006011391 183 INQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKVINATVWTLSFLVVLPMIIFADvqedIQTCNINWPEPmaVWST 262 coelacanth
XP_002932329 124 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLISATVWTLSFLVTLPVIIFSEvqpdYHTCNISWPDPvsVWAA 203 western clawed ...
XP_007901730 124 VTQFTSIFCLTVMSIDRYLAVVHPIKSTKWRKPRVAKMINATVWTSSIVVVLPVIIYSElqkdLNTCNIDWPEPksVWST 203 elephant shark
Feature 1         ### ### ##                                                   #  ## ##  #       
AAX55630     194 AFIIYTSVLGFFGPLLVICLCYLLIVIKVKssgirvgstrRRRSERKVTRMVVIIVVVFVFCWLPFYMMNIVNLIFILPe 273 chicken
P35346       200 VFIIYTAVLGFFAPLLVICLCYLLIVVKVRaagvr-vgcvRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPq 278 human
AAH68356     195 AFILYTAILGFFCPLLVICLCYLLIVIKVKsasaraglskRRKSEKKVTRMVVIIVVVFVICWLPFFMLNIFNLVVTLPe 274 zebrafish
XP_006011391 263 AFIIYTSVLGFFAPLLVICLCYLLIVIKVKssglrvgstkRRKSERKVTRMVVIIVVVFVFCWLPFYILNIVNLIVILPe 342 coelacanth
XP_002932329 204 AFIIYTSVLGFFGPLSVICLCYLLIVIKVKssglrvgstrRRRSERKVTRMVVIIVAVFVFCWLPFYILNIVNLSFFVPe 283 western clawed ...
XP_007901730 204 AFIIYTATLGFFGPLLIICLCYLMIVIKVKssrlrvgstkRRKSEKKATRMVIVIVAVFVFCWLPFYVLNIVNTIVILPe 283 elephant shark
Feature 1           ## ###  #  ##                     
AAX55630     274 dpvLVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 310 chicken
P35346       279 epaSAGLYFFVVILSYANSCANPVLYGFLSDNFRQSF 315 human
AAH68356     275 nniITGVYFLTVILTYVNSCANPLLYGFLSDNFKRSF 311 zebrafish
XP_006011391 343 epaLVGVYFSVVVLSYANSCANPILYVFLSDNFKQSF 379 coelacanth
XP_002932329 284 epaFAGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 320 western clawed frog
XP_007901730 284 kpiFVGIYFFGVVLPYANSCANPVLYCFLSDNFKKSF 320 elephant shark

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