1RHH,1XIW,1ZV5,1ZVO,2IG2,2ZJS,3DGG,4ZSO,5CMA,6W41


Conserved Protein Domain Family
IgV_H
?
cd04981: IgV_H 
Immunoglobulin (Ig) heavy chain (H), variable (V) domain
The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.
Links
?
Statistics
?
PSSM-Id: 409370
Aligned: 22 rows
Threshold Bit Score: 173.65
Created: 23-Apr-2007
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
  next features
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1RHH; human monoclonal antibody X5 IgV light and heavy chain heterodimer interface, contacts based on 3.5 A distance.
  • Structure:1RHH; human monoclonal antibody X5 Fab light and heavy chain heterodimer interface (including constant domains of Fab), contacts based on 3.5 A distance.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           #   #   #                                 
1RHH_B      4 LLEQSGAEVKKPGSSVQVSCKASGGTf--SMYGFNWVRQAPGHGLEWMGGIIpi-fGTSNYAqkf-rgRVTFTADQATST 79  Homo sapiens
1ZV5_A      3 QLVESGGGSVQAGESLRLSCAASGVTy--KNYCIGWFRQAPGKDREGVVFINs--dGGITYYadsvkgRFTISQDNAKNT 78  Camelus dromedarius
1ZVO_C      3 QLQESGPGLVKPSETLSLTCIVSGGPirrTGYYWGWIRQPPGKGLEWIGGVYy--tGSIYYNpsl-rgRVTISVDTSRNQ 79  human
2IG2_H      3 QLVQSGGGVVQPGRSLRLSCSSSGFIf--SSYAMYWVRQAPGKGLEWVAIIWdd-gSDQHYAdsv-kgRFTISRNDSKNT 78  Homo sapiens
S17597      3 QLEESGGGVVQPGRSLRLSCEASGLRf--SIYGMFWVRQAPGKGLEWLALIWnd-gSRKHYAdsv-kgRFTVSRDNSKNT 78  human
123772     20 TLQESGPGTVKPSESLRLTCTVSGFEl--TSYYVYWIRQPPRKTLEWIGVVRtd-gSTAIADsl--knRVTITKDNGKKQ 94  African clawed frog
B46529     25 TLDESGGGLVSPGGSLTLVCKGSGFTf--SSYGVSWVRQAPGKGLEWVAGITds-gGSTYYApav-kgRFTISRNNGQST 100 Anas platyrhynchos
AAA85662   32 QLKESGPGLVKPSQTLSLTCTVSGLSl--SSNSVGWVRQAPGKGLEWVGFRSg---GEEEYYnpalksRATITEDAAKSQ 106 horse
ABA62053    3 QLLESGPGLVKPSQTLSLTCAISGDSvssNSAAWNWIRQSPSRGLEWLGRTYyrskWYSDYAvsv-ksRITINPDTSKNQ 81  human
CAM73236   23 TLVESEAVVIKPDQSHKLTCTASGFNf--GGSWMAWIRQAAGKGPEWVATLSng-nSYIYYSdkv-kgRFTISRDDNKNQ 98  zebrafish

Feature 1                     #                         ##        
1RHH_B     80 AYMELTNLRSDDTAVYYCARDfgpdwedgdsydgsgrgfFDFWGQGTLVTVS 131 Homo sapiens
1ZV5_A     79 VYLQMNSLKPEDTASYYCAAGyrny----------gqcaTRYWGQGTQVTVS 120 Camelus dromedarius
1ZVO_C     80 FSLNLRSMSAADTAMYYCARGnpppyydi---gtgsddgIDVWGQGTTVHVS 128 human
2IG2_H     79 LFLQMDSLRPEDTGVYFCARDgghgfcs-----sascfgPDYWGQGTPVTVS 125 Homo sapiens
S17597     79 LYLQMNSLRADDTAVYFCGSGttafsga-----apdnyhIHVWGKGTTVTVS 125 human
123772     95 VYLQMNGMEVKDTAMYYCTSTlagt-----------agyFEHWGQGTMVTVT 135 African clawed frog
B46529    101 ATLQMNSLKAEDTATYYCAKGayggi---------rssdIDLWGHGTEVAVS 143 Anas platyrhynchos
AAA85662  107 VYLDAEQVTGEATAVYYCAEVynnyl---------yygiKELGARGLLVTVS 149 horse
ABA62053   82 FSLQLNPVTPEDTAVYYCARDpgds----------ysshFDYWGQGTLVTVS 123 human
CAM73236   99 LYLQMNSLKTEDTAVYYCARGmew-------------ryFDYWGKGTKVTVS 137 zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap