3NYQ,4FUQ,4FUT,4GXQ,4GXR


Conserved Protein Domain Family
MCS

?
cd05941: MCS 
Click on image for an interactive view with Cn3D
Malonyl-CoA synthetase (MCS)
MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Statistics
?
PSSM-Id: 341264
Aligned: 21 rows
Threshold Bit Score: 474.856
Created: 5-Oct-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3NYQ; Streptomyces coelicolor Malonyl-CoA ligase binds methylmalonyl-CoA and AMP, contacts at 4A.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3NYQ_A        38 DRPALRfg-----------erSLTYAELAAAAGATAGRIgg-------aGRVAVWATPAme---------tgVAVVAALL 90  Streptomyces co...
4FUQ_A        17 HKLAIEtaa----------gdKISYAELVARAGRVANVLvarg--lqvgDRVAAQTEKSve---------alVLYLATVR 75  Rhodopseudomona...
4FUT_A        17 HXLAIEtaa----------gdXISYAELVARAGRVANVLvarg--lqvgDRVAAQTEXSve---------alVLYLATVR 75  Rhodopseudomona...
4GXQ_A        17 HXLAIEtaa----------gdXISYAELVARAGRVANVLvarg--lqvgDRVAAQTEXSve---------alVLYLATVR 75  Rhodopseudomona...
4GXR_A        17 HXLAIEtaa----------gdXISYAELVARAGRVANVLvarg--lqvgDRVAAQTEXSve---------alVLYLATVR 75  Rhodopseudomona...
NP_503845     37 SKVLFIdd-----------grKITYGDFVQRAGQYATALtekyk-ikkgDRVMARVSKTtd---------taALYAACLQ 95  nematode
XP_636205     22 DRTSFInypn-------nntqRYPYRDFFNESQSIANILnfkkk-dleqQRVAYFFGQNfd---------yvRSQWGIWA 84  Dictyostelium d...
XP_003862224 193 DKIPRRapreprlhndsdvtsNTFLVDTVYDAALLVRDItakrdikgtaTLQAEWLPPAesacspmlsaedvVKRLDDEK 272 Leishmania dono...
NP_215709     16 IADAVRid-----------gdVLSRSDLVGAATSVAERVag-------aHRVAVLATPTas---------tvLAITGCLI 68  Mycobacterium t...
YP_354126     17 ASDLIIlkd----------gtRLSGDAFFRLLARTAHALraeg--lrpgDRIAVQVAKSpe---------alAVYGAAVA 75  Rhodobacter sph...
Feature 1                                                                                        
3NYQ_A        91 AGVAAVPLNPKSgdkELAHILSDSAPSLVLappdaelppalgalervd-----------------vdvrargavpedgad 153 Streptomyces co...
4FUQ_A        76 AGGVYLPLNTAYtlhELDYFITDAEPKIVVcdpskrdgiaaiaakvgatvetlgp--dgrgsltdaaagaseafatidrg 153 Rhodopseudomona...
4FUT_A        76 AGGVYLPLNTAYtlhELDYFITDAEPXIVVcdpsxrdgiaaiaaxvgatvetlgp--dgrgsltdaaagaseafatidrg 153 Rhodopseudomona...
4GXQ_A        76 AGGVYLPLNTAYtlhELDYFITDAEPXIVVcdpsxrdgiaaiaaxvgatvetlgp--dgrgsltdaaagaseafatidrg 153 Rhodopseudomona...
4GXR_A        76 AGGVYLPLNTAYtlhELDYFITDAEPXIVVcdpsxrdgiaaiaaxvgatvetlgp--dgrgsltdaaagaseafatidrg 153 Rhodopseudomona...
NP_503845     96 IGALYVPVNPALtqsEAAHYVKDAKPSLWItckddadqiamfqrvlktvcidnpvevinekvladeagkrkactmiehve 175 nematode
XP_636205     85 AGGTAVPLALSHpihELQYTIENSKSSMILtnsenyskmkeigtnlnipvieipk--vgeytipksqwssmedykqysid 162 Dictyostelium d...
XP_003862224 273 ASAKARELDRQAeiaQQEHLRRNRAPTEAVggadpagndgdgeslfcfdsah--------ldelnrvyqrwyampsarpt 344 Leishmania dono...
NP_215709     69 AGVPVVPVPADVgvtERRHMLTDSGVQAWLgplpddpaglphipvr---------------------tharswhrypeps 127 Mycobacterium t...
YP_354126     76 LGAVFLPLNTAYtpaEVDYFLGDATPRIFLcdsaqapaltpvaerhgarlltlda--dgtgdlaqrtrdrpeeigaeprd 153 Rhodobacter sph...
Feature 1                 #                                       ##  ###                        
3NYQ_A       154 dgDPALVVYTSGTTGPPKGAVIPRRALATTLDALADaWQWTGEDVLVQGLPLFHVHGLvLGILGPLRRGGSVRHLGRFst 233 Streptomyces co...
4FUQ_A       154 adDLAAILYTSGTTGRSKGAXLSHDNLASNSLTLVDyWRFTPDDVLIHALPIYHTHGLfVASNVTLFARGSXIFLPKFdp 233 Rhodopseudomona...
4FUT_A       154 adDLAAILYTSGTTGRSXGAMLSHDNLASNSLTLVDyWRFTPDDVLIHALPIYHTHGLfVASNVTLFARGSMIFLPXFdp 233 Rhodopseudomona...
4GXQ_A       154 adDLAAILYTSGTTGRSXGAMLSHDNLASNSLTLVDyWRFTPDDVLIHALPIYHTHGLfVASNVTLFARGSMIFLPXFdp 233 Rhodopseudomona...
4GXR_A       154 adDLAAILYTSGTTGRSXGAMLSHDNLASNSLTLVDyWRFTPDDVLIHALPIYHTHGLfVASNVTLFARGSMIFLPXFdp 233 Rhodopseudomona...
NP_503845    176 ksNAATICFTSGTTGAPKGAVLSHGALTNNTNALVQeWGFTENDVNLHCLPIFHAHGLyFSLHCSLFSHSSVIWRPNFda 255 nematode
XP_636205    163 snRNALIIYTSGTTSKPKGVVTTHANIEAQIQTLVDyWKWTEKDHILEVLPLHHVHGViNVVSCALWSGAICEMMPKFds 242 Dictyostelium d...
XP_003862224 345 kyDDCLMLYTSGTTAKPKGVVHTHASVANMVKVLQDaWQWRDTDSILHVLPWHHVHGLvNILLCALASNARCVVTTFDda 424 Leishmania dono...
NP_215709    128 pgAIAMVVYTSGTTGPPKGVQLSRRAIAADLDALAEaWQWTAEDVLVHGLPLYHVHGLvLGLLGSLRFGNRFVHTGKPtp 207 Mycobacterium t...
YP_354126    154 aeDLAALLYTSGTTGRSKGAMLSQRNLLSNAEALADlWRFTERDVLIHALPIFHTHGLfVASNVTLLTRGSMIFLPGFdl 233 Rhodobacter sph...
Feature 1                                 # #   #                               ###              
3NYQ_A       234 ---------egAARELNDGATMLFGVPTMYHRIAEtlpadp-------elakalAGARLLVSGSAALPVHDHERIAAATG 297 Streptomyces co...
4FUQ_A       234 ----------dKILDLXARATVLXGVPTFYTRLLQsprlt----------kettGHXRLFISGSAPLLADTHREWSAKTG 293 Rhodopseudomona...
4FUT_A       234 ----------dXILDLMARATVLMGVPTFYTRLLQsprlt----------xettGHMRLFISGSAPLLADTHREWSAXTG 293 Rhodopseudomona...
4GXQ_A       234 ----------dXILDLMARATVLMGVPTFYTRLLQsprlt----------xettGHMRLFISGSAPLLADTHREWSAXTG 293 Rhodopseudomona...
4GXR_A       234 ----------dXILDLMARATVLMGVPTFYTRLLQsprlt----------xettGHMRLFISGSAPLLADTHREWSAXTG 293 Rhodopseudomona...
NP_503845    256 ----------eDCSKHLKNATVFMGVPTFYSRLLAtnnfn----------kesfEKIRLFISGSAPLSVPTLEEFEKRTG 315 nematode
XP_636205    243 kqvvdrllesgISTDLDQPISLFMAVPTIYSKLIKyvnenitdpterlaienafKRLRLMVSGSSALPESVRNEFQAISG 322 Dictyostelium d...
XP_003862224 425 a--------rvAHRLEQGDITLFMAVPTVYVKLSDavqrkfspiektgfrkacmESVRLMVCGSAPLPVPTLNQFCELSG 496 Leishmania dono...
NP_215709    208 a--------gyAQACYEAHGTLFFGVPTVWSRVAAdqaa-----------agalKPARLLVSGSAALPVPVFDKLVQLTG 268 Mycobacterium t...
YP_354126    234 ----------eAILRWMPAATALMGVPTFYTRLLSdprlt----------ralaAGMRLFVSGSAPLLADTHAEFEARTG 293 Rhodobacter sph...
Feature 1            ######   #                #                                                 
3NYQ_A       298 RRVIERYGMTETLMNTSVRAd--GEPRAGTVGVPLPGVELRLVeedgtpi---------aaldgesVGEIQVRGPNLFTE 366 Streptomyces co...
4FUQ_A       294 HAVLERYGXTETNXNTSNPYd--GDRVPGAVGPALPGVSARVTdpetgk-----------elprgdIGXIEVKGPNVFKG 360 Rhodopseudomona...
4FUT_A       294 HAVLERYGMTETNMNTSNPYd--GDRVPGAVGPALPGVSARVTdpetgx-----------elprgdIGMIEVXGPNVFXG 360 Rhodopseudomona...
4GXQ_A       294 HAVLERYGMTETNMNTSNPYd--GDRVPGAVGPALPGVSARVTdpetgx-----------elprgdIGMIEVXGPNVFXG 360 Rhodopseudomona...
4GXR_A       294 HAVLERYGMTETNMNTSNPYd--GDRVPGAVGPALPGVSARVTdpetgx-----------elprgdIGMIEVXGPNVFXG 360 Rhodopseudomona...
NP_503845    316 QVILERYGMTEAGVIASNPLk--GKRKAGTVGQALKGVQCRVTe----------------------NGEIEIKSDSIFSE 371 nematode
XP_636205    323 QVLLERYGMTEIGMALSNPLk-vNERIGGTVGFPLPGVQIKIQpelnnddnqnnnqnnndnnnnkeVGELLVKGPQVFKE 401 Dictyostelium d...
XP_003862224 497 HTLLERYGMTEIGMALSQPLhpiADRHPGTVGSPLPTVKTYVHqpetaeameq---asakeaeydeVGSLGIASESLFDR 573 Leishmania dono...
NP_215709    269 HRPVERYGASESLITLSTRAd--GERRPGWVGLPLAGVQTRLVdddggev----------phdgetVGKLQVRGPTLFDG 336 Mycobacterium t...
YP_354126    294 HRILERYGMTETNMSTSNPYe--GERRAGTVGFPLPGVELRILdqgre-------------vapgeIGVIEVRGPNVFQG 358 Rhodobacter sph...
Feature 1                                 #               #       # # #  #                       
3NYQ_A       367 YLNRPDATAAAFt----eDGFFRTGDMAVRDp----DGYVRIVGRKATDLIKsGGYKIGAGEIENALLEHPEV-REAAVT 437 Streptomyces co...
4FUQ_A       361 YWRXPEKTKSEFr----dDGFFITGDLGKIDe----RGYVHILGRGKDLVIT-GGFNVYPKEIESEIDAXPGV-VESAVI 430 Rhodopseudomona...
4FUT_A       361 YWRMPEXTXSEFr----dDGFFITGDLGXIDe----RGYVHILGRGXDLVIT-GGFNVYPXEIESEIDAMPGV-VESAVI 430 Rhodopseudomona...
4GXQ_A       361 YWRMPEXTXSEFr----dDGFFITGDLGXIDe----RGYVHILGRGXDLVIT-GGFNVYPXEIESEIDAMPGV-VESAVI 430 Rhodopseudomona...
4GXR_A       361 YWRMPEXTXSEFr----dDGFFITGDLGXIDe----RGYVHILGRGXDLVIT-GGFNVYPXEIESEIDAMPGV-VESAVI 430 Rhodopseudomona...
NP_503845    372 YWKNPEKTKEEFt----eDGWFKTGDVGSLDk----DGYLTIGGRSKDMIIS-GGENIYPKEIEDAIDSIEFV-KESAVI 441 nematode
XP_636205    402 YFEKRKATEEAFt----dDGWFKTGDIVEKDl---sTGRLKILGRSSVDIIKrGGFKISALEIEREILDMDPNiQECAVL 474 Dictyostelium d...
XP_003862224 574 YWNNATATKKEVrtnaagMRFFDTGDTVGVRlpagkSAVYTILGRSSVDIIKsRGYKLSALEIEATLLARNDLfYEMAVV 653 Leishmania dono...
NP_215709    337 YLNQPDATAAAFd----aDSWYRTGDVAVVDg----SGMHRIVGRESVDLIKsGGYRVGAGEIETVLLGHPDV-AEAAVV 407 Mycobacterium t...
YP_354126    359 YWQMPEKTAEELr----pDGFFVTGDLGCRDa----EGYVQIVGRQKDLIIS-GGYNIYPKEVELLLDEQPGV-LESAVV 428 Rhodobacter sph...
Feature 1              #                                                     #                   
3NYQ_A       438 GEPDPDLGERIVAWIVPAdpa----------------apPALGTLADHVAARLAp-HKRPRVVRYLDAVPRNDMGKIMKR 500 Streptomyces co...
4FUQ_A       431 GVPHADFGEGVTAVVVRDkg-----------------atIDEAQVLHGLDGQLAk-FKXPKKVIFVDDLPRNTXGKVQKN 492 Rhodopseudomona...
4FUT_A       431 GVPHADFGEGVTAVVVRDxg-----------------atIDEAQVLHGLDGQLAx-FXMPXXVIFVDDLPRNTMGAVQXN 492 Rhodopseudomona...
4GXQ_A       431 GVPHADFGEGVTAFVVLXrefa--------------pseILAEELXAFVXDRLAx-FXMPXXVIFVDDLPRNTMGAVQXN 495 Rhodopseudomona...
4GXR_A       431 GVPHADFGEGVTAFVVLXre-----------------faPSEAQVLHGLDGQLAx-FXMPXXVIFVDDLPRNTMGAVQXN 492 Rhodopseudomona...
NP_503845    442 AAPHPDFGEAVVAVVVPKnmve--------------deqKFEEDLIEMLRKKLAk-YKVPKKVILLEELPRNHITKVRKD 506 nematode
XP_636205    475 GLPNDEYGQDIAAIIVYKksk---------------kqpMSFEEFKTNCKQRLAhyKVPNKLLILENEIPKNAMSKVNKK 539 Dictyostelium d...
XP_003862224 654 GAADAVQGESVVAVVAMQpeaarargitfgegaawhetaAVTEELKKVALQLLAp-YKCPSRYIVVPEIPRNATGKVNKK 732 Leishmania dono...
NP_215709    408 GVPDDDLGQRIVAYVVGSa-------------------nVDADGLINFVAQQLSv-HKRPREVRIVDALPRNALGKVLKK 467 Mycobacterium t...
YP_354126    429 GLPLPDLGEAALAVLVPRpg-----------------vtLDPQAVLGAIADRLAr-FKQPRAAVLVEELPRNTMGKVQKT 490 Rhodobacter sph...
Feature 1            
3NYQ_A       501 ALNR 504 Streptomyces coelicolor
4FUQ_A       493 VLRE 496 Rhodopseudomonas palustris CGA009
4FUT_A       493 VLRE 496 Rhodopseudomonas palustris CGA009
4GXQ_A       496 VLRE 499 Rhodopseudomonas palustris CGA009
4GXR_A       493 VLRE 496 Rhodopseudomonas palustris CGA009
NP_503845    507 ILRA 510 nematode
XP_636205    540 ELLK 543 Dictyostelium discoideum AX4
XP_003862224 733 DLKK 736 Leishmania donovani
NP_215709    468 QLLS 471 Mycobacterium tuberculosis complex
YP_354126    491 LLRA 494 Rhodobacter sphaeroides

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap