Conserved Protein Domain Family
GT29_ST6GALNAC4
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cd23977: GT29_ST6GALNAC4 
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467705
Aligned: 4 rows
Threshold Bit Score: 462.024
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
Download Cn3D
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ###                    ##                    #                           
Q9H4F1        73 CRSCAVVSSSGQMLGSGlGAEIDSAECVFRMNqAPTVGFEADVGqRSTLRVVSHTSVPLLLRNYSHYFQkardTLYMVWG 152 human
NP_001072307  61 CKSCAVVSSSGQMLGSGlGPQIDQAECVLRMNtAPTLGYEADVGsRSSLRVVSHTSVPLLLRNQTYFFQqsqdTVYVIWG 140 tropical clawed...
NP_989842     60 CRRCAVVSSSGQMLGSHlGREIDGQECVLRMNhAPTAGFEEDVGtRSTVRVVSHTSVPLLLRNQPYFFQqsrdTIYVIWG 139 chicken
NP_001038835  57 CGRCAVVSSSGQMLGGGrGPEIDQQDCVIRMNvAPTAGYEADVGnRTSLRVVSHTSVPLLVRQQGYFFRreadTKYVIWG 136 Danio rerio

Feature 1                                                                   ###                 #
Q9H4F1       153 QGrhmdrvlgGRTYRTLlqltrMYPGLQVYTFTERMMAYCDQIFQDETGKNRrqsGSFLSTGWFTMILALElCEEIVVYG 232 human
NP_001072307 141 PLrqmd-idsGITYRVLqhtkgMYPQVQIYTLTQSMMAHCDLVFQNETGKNRamsGTFLSTGWFTMILAMElCEEITVYG 219 tropical clawed...
NP_989842    140 PSrkmsrekgGPTHRALlrvleMYPRLQLYTLTEEKMAYCDDVFQNETGKNRlksGSFLSTGWFTMILAMElCEHICVFG 219 chicken
NP_001038835 137 PEknmrqdgkGKTFNALvtlakKYPHSHVHTITREKVQYCDGVFQNETGKNRmksGAFLSTGFFTMILALEvCDSILVYG 216 Danio rerio

Feature 1        #              ###                       #                          
Q9H4F1       233 MVSDSYCRekshpsVPYHYFEKGRLDECQMYLAHEQaprsaHRFITEKAVFSRWAKKRPIVFAHPSWR 300 human
NP_001072307 220 MVGENYCRnrfnppVPYHYYEKGRLDECTMYMMHERasrgaHRFITEKAVFARWAHRKQIHFAHPSWG 287 tropical clawed frog
NP_989842    220 MVSDSYCReknhssVPYHYFEKGRLDECRMYLVHERapragHRFITEKAIFSRWAKRKDIIFSHPSWA 287 chicken
NP_001038835 217 MIDGSYCSnanhsfVPYHYYEPLHLDECRMYRVHEHakrggHRFITEKLIYSRWASQGKLRFVYPPWT 284 Danio rerio

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