Conserved Protein Domain Family
PRK11856

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PRK11856: PRK11856 
branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed
Statistics
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PSSM-Id: 237001
Aligned: 562 rows
Threshold Bit Score: 250.864
Created: 9-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
284166851   1 MLREFELPDVGEGVAEGELVSWLVEEGETVSEDQPVAEVETDKALVEVPAPVNGTVRELHVEEGEVVPVGTVIISFNVEG 80 
28900500    2 EMKTFNLPDLGEGLAESEIVKWHVNVGDMVKLDQVILTVETAKATVDVPAPYAGRIVSRHGEEGDVINIGALLLEIDESG 81 
37520661    2 VITEIKIPQLGEGLQEVLIDRLLKRSGEHIKRDEAIYVIETDKALMDVESPYEGVIQEWLVEENDVVLVGSPVARIQ--- 78 
37525808    1 -MAQLLIPPMGEGTTEVVIIQLLKQVGDHVKRDEPVYEMETDKAAFTIESDVEGILEKWLAAENDIIPVGSPIAVIRAVG 79 
37676683    1 -MKTFILPDLGEGLAESEIIKWHVSVGDKVEVDQVILTVETAKATVDVPAPWAGTIITRHGNEGDVVNIGALLLEIE--- 76 
54302775    2 EMKSFMLPDLGEGLAESEIVEWHIKSGDVVRVDQIVLTVETAKATVDIPAPYSGKIISRYGKEGDVINIGSLLLEIEEVG 81 
27366907    1 -MKTFILPDLGEGLAESEIIKWHVSVGDKVEVDQVILTVETAKATVDVPAPWAGTIITRHGNEGDVVNIGALLLEIE--- 76 
156976778   1 -MKTFNLPDLGEGLAESEIVKWHISVGDMVQLDQIVLTVETAKATVDVPAPYGGRIVSRHGEEGDVINIGALLLEIDETG 79 
212219127   1 -MKVFKLPDLGEGLPDATIREWYIAVGDEVKIDQPLVAMETAKALVDVPSPLASKIEKLFGEVGDVIETGSPLIGFE--- 76 
262396876   1 -MKTFNLPDLGEGLAESEIVKWHVNVGDMVKLDQVILTVETAKATVDVPAPYSGRVVSRHGEEGDIVNIGALLLEIDETG 79 
284166851  81 EesetttdeEQGRAGEPEGVDAPEEATTAGSETGAET--------------DEAAGSPEAIGADAEetatp--qdrvFAP 144
28900500   82 A--------ENTVSAEKRQTADAATVVGSVSHQSHNV--------------NVDDFWVGGSHNKSTdk-------liTAL 132
37520661   79 ---------TIIEHSAAPHLEPRKAEFPETKPKSQIA--------------PSSSA---------------------VIP 114
37525808   80 E--------MAEPSPVSEALTPPPEKMERVAEDVEKI--------------EKVEAAPEVSAPPA------------RIP 125
37676683   77 ---------DGDVATNSDKKVQKREDAATVVGHVSNQ--------------MHQVKVDDFWIGGNQnhtt---ekrvTAL 130
54302775   82 A--------TAQSTISTTASTTAAKKEDAATVVGNVS--------------HQSHHVDIDDFWVGSdqntt-hdniiTAM 138
27366907   77 ---------DGDVTENSDQKVQQREDAATVVGHVSNQ--------------MHQVKVDDFWIGGNQnhtt---ekrvTAL 130
156976778  80 A----------------EQAATEQKQTADAATVVGNV--------------SQHAHSVNVDDFWIGgehnpspdnliSAL 129
212219127  77 ---------GEAETEEPKDTGTVVGAIETSDTVLEES--------------GAGIPVKKAAEKKNF-----------KAT 122
262396876  80 A--------ERGAAVEKKETADAATVVGNVSHQAHHVnvddfwiggnhnttESNLV---------------------TAL 130
284166851 145 PRVRRMAREEGID---LSSL-EGSGPGGRITAADVQ-----------AAASggpvggaqaqqpaETAAESGATTGDSSET 209
28900500  133 PSARLLAKKLGVD---LKTM-VGSGPSGLIVDADVY-----------EEAGkq--------------------------- 170
37520661  115 PRTRAYCKQLGIP---EDEMlQISALTEKLMPRDVD-----------KYVA----------------------------- 151
37525808  126 PKTRQYAQEHQIEpliLSQL---AEKHGTLLPGHID-----------DYLQ-------------QHRETKISEETRPSEK 178
37676683  131 PSARLLAQKLGVN---LEMV-SGTGPSGLIMDHDVY-----------DEAG----------------------------- 166
54302775  139 PSARLLAQRLGVD---LHGI-IGSGPDGLIVDADIY-----------NECD----------------------------- 174
27366907  131 PSARLLAQKLGVN---LEMV-SGTGPSGLIMDHDVY-----------DEAG----------------------------- 166
156976778 130 PSARLLANKLGVD---LASV-KGSGPDGLILDSDIY-----------DEAGkq--------------------------- 167
212219127 123 PAVRMLAKQLGVD---LTKI---TPKGSLISAEDVKqaaqitktgktQKIE----------------------------- 167
262396876 131 PSARLLAQKLGVD---LNLV-SGSGPNGLIVDADIY----------------------------DEAGKQRPGTEV---- 174
284166851 210 GGaavetegrteaesgieseagsgaasagepttppanlesadrdktlaapatrriarekgididavptdeeregeafvtp 289
28900500      --------------------------------------------------------------------------------    
37520661      --------------------------------------------------------------------------------    
37525808  179 SNtend-------------------------------------------------------------------------- 184
37676683      --------------------------------------------------------------------------------    
54302775      --------------------------------------------------------------------------------    
27366907      --------------------------------------------------------------------------------    
156976778     --------------------------------------------------------------------------------    
212219127     --------------------------------------------------------------------------------    
262396876     --------------------------------------------------------------------------------    
284166851 290 eavreyaeaqqraQEADReaveaGEPVGakgtdfaegererrepFRGVRKRIAEAMVESKYSAPHVTHHDEVDVTEL--- 366
28900500  171 ----------------------vPGTEV----------------LKGARRTMVSTMAESHQNVAAVTITEEALLEDWl-- 210
37520661  152 -------------AKSNPeilpsLEQVRcdyl---------ersISGKQKTLLYRLKRSTELVVPGTISRPVAWFRLqeg 209
37525808  185 ----------------------------------------nvgfLSRDQQRLNRAIRLNSAAVQPCWAAKPLPIELV--- 221
37676683  167 -------------KQRPG-----TEV------------------LKGARRTMMTTMTESHLQVAAVTITEEALLEHW--- 207
54302775  175 -------------KQLPG-----TEV------------------LKGARRTMVNTMAESHHNVAAVTITEEALLADW--- 215
27366907  167 -------------KQRPG-----TEV------------------LKGARRTMMTTMTESHLQVAAVTITEEALLEHW--- 207
156976778 168 ----------------------rPGTEV----------------LKGARRTMVSTMAESHHNVAAVTITEEAVLDGWk-- 207
212219127 168 -----------------------GELTP----------------LSPVRRAMAQSMSQSHREVVPVSLMDDGDLSAW--- 205
262396876 175 --------------------------------------------LKGARRTMVSSMTESHEHVAAVTITEEALLEDWl-- 208
284166851 367 ----VEAREELkpraeergiRLTYMPFIMKAVVAALQEFPEMNAVID--EegdeIV--YRDYYNVGVATA-TDVGLMVPV 437
28900500  211 -------------------pNEDISIRLVQAIVYACQQEPALNAWFDaeT----MTrcVHPTVNLGVAVD-SRHGLYVPV 266
37520661  210 iqilTNRGDSP---------LPSEFQMFAYCVAQASKKHPKFRSVLTgeNs---VR--EYRLLNLGIAIArPNDELITAV 275
37525808  222 ----DNAIHHLtets-gqqeWITPFQVITYAISQALKKFPMLRSRPLdqEr---YH--TYTDINLGIAFLdEKGDLSSLK 291
37676683  208 ----SS--------------QEDITVRLVQAVVYACQQEPALNAWFDadT----VTrcVHHTVNIGVAVD-SAHGLYVPV 264
54302775  216 ----LA--------------NEDISIRLIQAVINACQQEPALNAWFDaeT----MTrcVHSTVNVGIAVD-SAHGLYVPV 272
27366907  208 ----SS--------------QEDITVRLVQAVVYACQQEPALNAWFDadT----VTrcVHHTVNIGMAVD-SAHGLYVPV 264
156976778 208 -------------------qGEDISIRLVQAIVHACQEEPAMNAWFDaeT----MTrcVHSTVNIGIAVD-SRHGLYVPV 263
212219127 206 ----KG--------------EQDITLRIIRAIEAACQAVPIMNAHFDgeT----LGykLNETINIGIAVD-TPQGLYVPV 262
262396876 209 -------------------pNEDISIRLVQAIVHACQEEPALNAWFDaeT----MTrcVHNTVNLGIAVD-SRHGLYVPV 264
284166851 438 VENADEKGLLQLSSEMNELVQKARE-RSISPGELRGSTFTITNVGAIGGEYATPIINYPEAGILAIGAIKRK--PRVmtD 514
28900500  267 LRHADEYEPQDVRRWLDQTVKGIRD-RKISREDLQHATITLSNFGAIGGIFATPVVSPPQVAIVGAGRIVDR--VVI--R 341
37520661  276 IPEADCLSPAAFANTARRQMRKAIKeGDQASESTQ---ITLSYLGEYGIVDATPALVAPAVAVMFIGSTYGQ-------- 344
37525808  292 VPNTQTMSFFEFRQHLNGVLDPDAE----KLPVDIDVPMMISYTGNDGATFAVPVIVPPSQSTLFIGAPHNK-------- 359
37676683  265 MRHADEFSPDDIRSWINQTVSGIRE-RKIGREQLQHATITLSNFGAIAGIYATPVVSPPQVAIVGAGRIIEK--VVL--R 339
54302775  273 LRHADEYSPKGVRQWLDKTVKGIRD-RRIGREQLQHATITLSNFGAIAGIYATPVVSPPQVAIVGAGRIIEK--VII--K 347
27366907  265 MRHADEFSPDDIRSWINQTVSGIRE-RKIGREQLQHATITLSNFGAIAGIYATPVVSPPQVAIVGAGRIIEK--VVL--R 339
156976778 264 LRHADEYEPQEVRRWLDQTVQGIRE-RKIGRDQLQHATITLSNFGAIAGIYATPVVTPPQVAIVGAGRIIEK--VVI--R 338
212219127 263 LKDVSHQDDTALRNQINRFKELAQS-RSFPPEDLRDATIMLSNFGAFAGRYANPILLPPMVTIIGVGRTRDEivPVD--- 338
262396876 265 LRHADEYEPQDVRRWLDQTVEGIRE-RKIGREQLQHATITLSNFGAIAGIYATPVVTPPQVAIVGAGRILDR--VVI--R 339
284166851 515 eNGNesIEPRSVLTLSLSFDHRLIDGAIAAQFTNTV-------------------------------------------- 550
28900500  342 -NGQ--AVAVKAMPLSITFDHRACTGGEAARFTKVL-------------------------------------------- 374
37520661  345 -AGK------QVANIALTFDHRLINGAGAALFLNDI-------------------------------------------- 373
37525808  360 -E----------MSLVLAFNHYLLNGVEASEFISEIivqvralsgprsaahqiegkvgksvsgqlrtlladflhwdedft 428
37676683  340 -EGK--AVAVKAMPLSITFDHRACTGGEAARFTKAL-------------------------------------------- 372
54302775  348 -DGQ--PIAVKAMPLSMTFDHRACTGGEAARFIKAL-------------------------------------------- 380
27366907  340 -EGK--AVAVKAMPLSITFDHRACTGGEAARFTKAL-------------------------------------------- 372
156976778 339 -DGQ--AVAVKAMPLSITFDHRACTGGEAARFTKVL-------------------------------------------- 371
212219127 339 --GK--PAVHRILPLSVTSDHRVITGGEIARFLKQL-------------------------------------------- 370
262396876 340 -NGQ--AISVKAMPLSVTFDHRACTGGEAARFTKVL-------------------------------------------- 372
284166851 551 -----------------------------------------------MEYLENPSLLLL 562
28900500  375 -----------------------------------------------AEHLQRPSVTKS 386
37520661  374 -----------------------------------------------AQQVESFSSEL- 384
37525808  429 esmmprtwadlgidslkavklaelmsvhfrrklsptlfwryssphrlIEYLDTAKTELT 487
37676683  373 -----------------------------------------------AEHLRKPSV--- 381
54302775  381 -----------------------------------------------VEHLQQATV--- 389
27366907  373 -----------------------------------------------AEHLRKPSV--- 381
156976778 372 -----------------------------------------------AEHLRKPSV--- 380
212219127 371 -----------------------------------------------IDSLEKAS---- 378
262396876 373 -----------------------------------------------AEHLQRPSEK-- 382
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