6CNB


Conserved Protein Domain Family
BRF1

?
pfam07741: BRF1 
Brf1-like TBP-binding domain
In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling. This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions.
Statistics
?
PSSM-Id: 462250
Aligned: 134 rows
Threshold Bit Score: 50.6347
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6CNB_R       603 EDVDDE-ELNAHLLNEEASKLKERIWIGLNADFLLEQESKRLKQEADIATgNTSvkkkrtrrrnntrsdeptktvdaaaa 681 
XP_007793609 477 DEFENDvEVEYCVLSENEARIKQMIWINQNKDWLRKQQDLEYRRQMEELG-PPK-------------------------- 529 
EPQ65736     560 DEFAQDpEVQNCLLSPADVAMKEKVWINANKDWLRKQQLKEWNKKQAAND-PPK-------------------------- 612 
EKD13121     669 DEFAGDpEVEYCMLSAADTAKKEKVWSNDNKSWLRAQQVKDWAKKNAAKG-PQK-------------------------- 721 
ELR08694     539 SEFADDpEVANCLLSEAEAAIKEHIWVNANKDWLRDQAVKLYNQKIADKA--PK-------------------------- 590 
EDN96655     514 DEFADDeEVINCVLPDAEVAKKEQIWLNANKDWLRKQQQKDFEKRKAAMG-PPK-------------------------- 566 
XP_003009772 495 DEFADDvEVMNALLSPEEVKLKEIVWVNENQDWLRKNQQREFDRKLEAGK--PK-------------------------- 546 
EFQ36521     540 DEFADDpEVLNCMLTPEEIKIKELLWVNENKDWLRQSQERLFRKKLEEKK--PK-------------------------- 591 
EFY88552     555 DEFADDpEVQNCLLSPDEARIKELIWVNQNKDWLRQHQEKLFRKKVEAER--PK-------------------------- 606 
CCE28427     564 DEFADDpEVINCLLSPDEARIKELIWVNQNKDWLRQHQEKVFRRKVEAER--PK-------------------------- 615 
6CNB_R       682 iglmsdlqdKSGlhaalkaaeES-----GDFTTADSVKNMLQKAsFSKKINYDAIDGLF 735 
XP_007793609 530 ---------RKRnrhk--kprIGegqltPASTPGEAAVEAMKKRsFSKRINYDAISNLF 577 
EPQ65736     613 ---------AKRnrkk--kprMGegqtsAANSPAEAAISVLKQRsFSKKINYDAINGLF 660 
EKD13121     722 ---------AKRtrkp--kprIGegqtsAASSPGEAAVAALKERaFSKKINYDAINSMF 769 
ELR08694     591 ---------ARRnrvk--rprIGegqtrAASSPAEAAVEVLKERtWSKRINYDAIRGIF 638 
EDN96655     567 ---------VTRqrkk--kprIGegqtsVASTPAEAAVNAMKERsWSKKINYEAIRDIF 614 
XP_003009772 547 ---------RPRkrn---kprLGeaqtsPASTPIEAAQNVMKHHgMSKRLNYDAISSLL 593 
EFQ36521     592 ---------KDRkrkk--rprIGegqttPASTPGEAAVNVMKERgFSKRINYDAIRQMF 639 
EFY88552     607 ---------QTRrrrk--rarMGegqtsPASSAAEAAINVVKDRaWSKRINYDAIRSIF 654 
CCE28427     616 ---------QTRrrkk--qarMGegqtsPANSAAEAAINVAKDRaWSKRINYDAIRSIF 663 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap