7JKC,3IZ1,6L3T


Conserved Protein Domain Family
Connexin

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pfam00029: Connexin 
Connexin
Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.
Statistics
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PSSM-Id: 459638
Aligned: 179 rows
Threshold Bit Score: 156.891
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7JKC_A         3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDRAFPISHVRFWVLQI 82 
XP_006000586   3 EWSFLSSFLEYLQNHSPMVGRIWLVVMLIFRILILATVASDMFEDEQEEFACNTLQPGCKQVCYDKAFPISHYRFWVFHI 82 
XP_007255228   3 DFGFLSGLFESLQANSPMLGRFWLLLMLVFRMLILGTVASDMFEDEQEEFSCNTLQPGCKQVCYDQAFPISQYRFWVFHI 82 
XP_004080280   3 EWGFLGSLFDTLSSHSPMLGRFWLFLMLVFRILILGTVATDMFEDEQEEFICNTAQPGCKQVCYDMAFPISQYRFWVFHI 82 
XP_005448248   3 EWGFIGGFFKDFQTHLPMLGRCWLILVLVFRILILGTVASDMFEDEQEEFTCNTLQPGCKQVCYDEAFPISQYRFWVFHL 82 
XP_002127805   1 MWNILEKVSEQVSLYATLTGQVWYLLVYLFRLIVVVTIGSSVYSDEQSAFRCSTKVIGCDNVCYDKFAKISHIRFWAFQL 80  vase tunicate
XP_026691633     --------------------------------------------------------------------------------     vase tunicate
XP_019218348   3 EWDFISGFFDALQTRSPMLGRFWLFLVLVFRIVILETVASDMFEDEQEEFTCNTLQPGCKQVCYDMAFPISQYRFWVFHI 82  Nile tilapia
XP_025759016 199 EESVLSRLLALWHSHAGFLGKTVLPVLQLVRIVLVGAAVQPVW--SNDYFVCDTNQPGCSSAAYNAVFPFSVHQYWTLQV 276 Nile tilapia
XP_019207720   5 KLGFLSSVLCKWHAQATLIGKYLLPVLLLIRFVMLGAAVQTAWLNDREEFLCSTQQPGCETACFDAVTPLSLPRLWTLQL 84  Nile tilapia
7JKC_A        83 IFVSTPTLIYLGHVLHLVRME--EK-RKE--REEEPPkaagpAEEHQDPAPVRDDRGK-------V-----R-------- 137
XP_006000586  83 VLLSGPSICFVIYAMHHASKI--EKeKEA--LESGVS-----SNKSKRQTYNQ--------------------------- 126
XP_007255228  83 VLISTPALVFLMYAMHHHKKH--QD-FQQ-------------GSVSSLLVAKQ--------------------------- 119
XP_004080280  83 VLIATPSLLFLLYATHHHNKR--AN-------HSDSC-----LRSSKNFREEK--------------------------- 121
XP_005448248  83 ILIATPSLLYFVYVTHQDHKR--AN-------SSSSR-----KRSSRKNREGR--------------------------- 121
XP_002127805  81 LALSAPVIVFHFYTIHVKGRI--EK-LKVkeQEAIER-----EEQYQKELTKTEDTSKwgvirnsVnnkiqRrksrigkv 152 vase tunicate
XP_026691633   1 -----------------------------------------------mnrylgVRTANkrwkvltNhvipsElh------ 27  vase tunicate
XP_019218348  83 VLIATPSLLYLIYATHQHHKR--AN-------RSSSR-----KKTSRENREEK--------------------------- 121 Nile tilapia
XP_025759016 277 VFVLAPGLIYF--SYLVHLLVtqKQ----------------------SETGTV--------------------------- 305 Nile tilapia
XP_019207720  85 VLVLAPGLVFLCYLIHLTNQE--TQ--------------------VQRGNDEV--------------------------- 115 Nile tilapia
7JKC_A       138 -----------I-----AGALLRT-YVFNIIFKTLFEVGFIAGQYFLY--GF-QLKP-LYRCD-RWP------------- 182
XP_006000586 127 -----------------EDNLRKI-YIGNVAFRLLLEVGFTVGQWALY--GF-KVEA-QFPCE-RFP------------- 170
XP_007255228 120 -----------------QRHLKLL-YMVNVGFRLLSEIGFLVGQWLLY--GF-RVEA-QFPCS-RFP------------- 163
XP_004080280 122 -------------------RFKRF-YIINLLFRIGAEVGFIVGQWKLY--GF-EVKA-HFECE-RFP------------- 163
XP_005448248 122 -------------------ALRAL-YIITVIFRIVGEIGFLFVQWRLY--GF-EVKA-HFPCS-RSP------------- 163
XP_002127805 153 rpkkvyantqlEeitltRG--IKVaYFLSVLTRFVMEIIFLFLAYDLF--RFaEYPHtPNDGRiVSDgkrvagvfdlfwi 228 vase tunicate
XP_026691633  28 ----------kT-----RGQCIWRlYLLQIFSRMLIECVFIMLQYTVYfyRW-TVPQ-VFRCQ-VWP------------- 76  vase tunicate
XP_019218348 122 -------------------TLRAL-YIITLIFRIVAEIGFLFVQWRLY--GF-KVEA-HFPCS-RSP------------- 163 Nile tilapia
XP_025759016 306 -----------I-----KRQSLWA-YLGFLSAVVLLELGFAVGQCLKF--GL-FLPP-MFNVA-VSP------------- 350 Nile tilapia
XP_019207720 116 -----------------KGHTLSV-YRACVAFVIVVEVGCIAAQWLLY--GF-ELST-DFSCG-RSP------------- 159 Nile tilapia
7JKC_A       183 -----------------------CP-NT-VDCFISRPTEKTIFILFMLAVACVSLLLNVLEIYHLGW 224
XP_006000586 171 -----------------------CP-YT-VDCFVSRPMEKTIFLLFYFAVGVLSAVLSLVELITIIL 212
XP_007255228 164 -----------------------CP-YT-VDCFTSRPMEKTVFLVFYFAVGVLSAVSSLVEIIHVTR 205
XP_004080280 164 -----------------------CP-KI-VDCFTSRPAEKTIFLHFYFFVGVLSAFISFLELCYCTV 205
XP_005448248 164 -----------------------CP-LT-VECFTSRPKEKTIFLLFYFAVGVLSAFSSVVEFFYVSR 205
XP_002127805 229 rvpqlyrcggdsvrwacgqhmlpGNsDAyIPCWVSRPWEKTIFLRYMNTLSVICLFLALAEIIQIGI 295 vase tunicate
XP_026691633  77 -----------------------CP-HT-VDCFISRPQEKTVFFRYMYVISAFSILLSIGELLYIGW 118 vase tunicate
XP_019218348 164 -----------------------CP-LT-VECYTSRPAEKTIFLLFYFAVGVISAFSSI---VELly 202 Nile tilapia
XP_025759016 351 -----------------------CP-HT-VDCFLSQPNEKSVFMFIMLVLACLSGLLTLVEMCTVMK 392 Nile tilapia
XP_019207720 160 -----------------------CP-MR-VDCFLPHAWEKTVFLRIMFTASSVSILLNVVEAVCMLR 201 Nile tilapia
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