Conserved Protein Domain Family
FAM192A_Fyv6_N
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pfam10187: FAM192A_Fyv6_N 
FAM192A/Fyv6, N-terminal domain
This is a the N-terminal domain of the mammalian PIP30/FAM192A protein and the fungal Fyv6 protein. PIP30/FAM192A acts as a regulator PA28-gamma, a nuclear activator of the 20S proteasome. PIP30 favors PA28-gamma interaction with the 20S proteasome while inhibiting its association with coilin, a central component of nuclear Cajal bodies. Fyv6 is involved in telomere length regulation and required for survival upon exposure to K1 killer toxin. It promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.
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Statistics
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PSSM-Id: 462987
Aligned: 67 rows
Threshold Bit Score: 52.9726
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
jgi:OSTLU_26562  58 FVTESELeRLRALGgSDGGDASGASDARN----DDaNAG------KPLYQILAERREEKDREFQEQWAsMKVGKnkPLDE 127
CCD25613         33 FISEGNAdLESQEA-KAKIEQTKFELQGKir------------srKSLRAQLRSNAISKNRKFNKLVK-ERESFn-RLNK 97 
KDE09083         11 FVSEKQLtEAQEKR-QAEWKEAYARMGQEppptNPiEGEpy--dgRSLYEKLQEHKNKKQEAFDEALK-FKNQFr-ALDE 85 
XP_003322159     18 FVSSSDLeTARQKR-EEEWKATYQRLGQEa--pPMpNEEyd---gRSLYEKLKETKDKKQEAFEEKLK-FKNQFr-ALDD 89 
EPB91734          9 FVSRAVVeDDQEKQlESDGNQKEVVVQEAyd-------------pRTLYERLQEQRTLKEEKFAEESR-LSNQIk-RVDE 73 
EIE90716          9 fvSRSIVqANTEQTlESDKKTSEVKQDyd---------------pRTLYERLQEQKTLREEKFAEESR-LSNHIk-RIDE 71 
EEY68791         15 FVSTSVLtSSDGLFgDNVEEKRVSEAPAPr--sEDaAGY------KPLYEQLQERKERKDSEWKEKNNpFAPPk--GLDD 84 
CBN79705          6 FVSTSVLeSKDGIDfNEEVRKESEDV-------REaERIakeadkKPLWEQLAGKRDEKQAKFDAVRAsMFAPPr-ALDD 77 
XP_003061758     57 FVTETELmEIKAKRgGA----------------LRpEDGtme-adKTLWAVLQEAKDAKQEAFEEGWKtMKQGVykPLDD 119
XP_002509004     71 FVTESELaEIKAKRgGA----------------LRpEDGtme-peKPLWQVLQEAKDAKEEAFQEGWKtMKQGIykPVDE 133

jgi:OSTLU_26562 128 EEVEFLDEIESERRAAETKRKREEDGELEAFK 159
CCD25613         98 EEINFFKQIESEKLSKEKETERFLQKKLENFd 129
KDE09083         86 DEINFLDSMTDENNEEELARQQEIQDELRNFK 117
XP_003322159     90 EEVAFLDDAAEEKRAIEMAKQEEIQKEMKRFK 121
EPB91734         74 EEAEYFRTLSDEKEKLEYQRKIKETLELEEYR 105
EIE90716         72 EEAEYFKVLSDEKKKLEEERKRNERLELERYR 103
EEY68791         85 EEFEYIQDLESKKEDVERQRQAQHEEDLAQFl 116
CBN79705         78 EESNFLQGVEAQRLEAKERKKKWETEELRGFa 109
XP_003061758    120 EEAEFIDEVETRKRSEERRAEEREKSEVDAFK 151
XP_002509004    134 EEVEFLDEVADRRREEEQRLKQREQDEAEAFR 165
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