1RPX,1H1Y,1TQJ,1TQX,2FLI


Conserved Protein Domain Family
RPE
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cd00429: RPE 
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Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose phosphate pathway. In the Calvin cycle Ru5P is phosphorylated by phosphoribulose kinase to ribulose-1,5-bisphosphate, which in turn is used by RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) to incorporate CO2 as the central step in carbohydrate synthesis.
Links
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Statistics
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PSSM-Id: 238244
Aligned: 133 rows
Threshold Bit Score: 173.82
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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metal bindingsubstratehexamer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:2FLI; Streptococcus pyogenes ribulose phosphate epimerase with bound zinc
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    # #                              #                 
1RPX_A       12 IVSPSILSANFSKLGEQVKAIEqagcDWIHVDVMDgRFVPNITIGPLVVDSLRPitdlPLDVHLMIVEP--DQRVPDFIK 89  potato
2FLI_A        5 KIAPSILAADYANFASELARIEetdaEYVHIDIMDgQFVPNISFGADVVASMRKhsklVFDCHLMVVDP--ERYVEAFAQ 82  Streptococcus py...
732069        2 ILHPSLASANPLHYGRELTALDnldfGSLHLDIEDsSFINNITFGMKTVQAVARqtphPLSFHFMLARP--QRWFNALAE 79  Escherichia coli
AAK03364     14 PISVGILASDWLKFADTLTTLSrhhlRLLHFDIGDgQFSPFFTVGALAVKQFPSp--wLKDVHLMVNDP--FHVAKACAD 89  Pasteurella mult...
BAB53382     21 IAEFSLWSANLANFESDLRRIEph-vDLHHIDVADgHFAPSFLFFPDLVARIAGltakPIHVHLMVDAAivEAQTRQFIE 99  Mesorhizobium lo...
ZP_00232911   5 LICPSMMCADFSGLEREVEELDkagsDVFHVDIMDgAFVPSFGMGLQDFEEIRQktqkLVDVHLMIMNP--GDYVEMFAD 82  Listeria monocyt...
AAV79688     21 PLSVGILAGQWIALHRYLQQLEalnqPLLHLDLMDgQFCPQFTVGPWAVEQLPQt--fIKDVHLMVADQ--WTAAQACVK 96  Salmonella enter...
ZP_00566735  22 LVDVSVWSADLACLRAEIERASpv-aDLFHFDVGDsQFVPDLLFFPDLLAALRPlttvPFHAHLMVRRP--APLAALFAQ 98  Frankia sp. EAN1pec
YP_480902    25 LLDVSLWSADLAALGVELDRTSgv-aDVVHFDIADgSFGPDLMFSPAMLAALRPrttvPFHAHLLARRP--IALIDAVTT 101 Frankia sp. CcI3
YP_519245     5 LFSASMMCANYGHLETEIRSLEtagiDSFHVDIMDgHFVHNFAMGLYELKYICRtakkNVECHLMITDP--YNYIDTFAD 82  Desulfitobacteri...

Feature 1                                                                                       
1RPX_A       90 agadIVSVHCEqsstiHLHRTINQIKSLg---------AKAGVVLNPGTPLTAIEYVLdavDLVLIMSVNPGFGGQSFIE 160 potato
2FLI_A       83 agadIMTIHTEst--rHIHGALQKIKAAg---------MKAGVVINPGTPATALEPLLdlvDQVLIMTVNPGFGGQAFIP 151 Streptococcus py...
732069       80 irpaWIFVHAEtl--dYPSETLTEIRHTg---------ARAGLVFNPATPIDAWRYLAselDGVMVMTSEPDGQGQRFIP 148 Escherichia coli
AAK03364     90 agadIITLQVEqt--dCLAETISYLREHyp-------dLLIGLTLCPDTEIDLLTPYLaqvDLIQILTLDPRTGVKAETD 160 Pasteurella mult...
BAB53382    100 agadMISVHAEng--eAGLRAVRLARELg---------AEAGVVLRLETPVEAVKPFVsevAFVTLLGTAIGVKGQSLSD 168 Mesorhizobium lo...
ZP_00232911  83 kgadIIYIHPEad--lHPARTLDKIRNKg---------KKVGIAINPGTAIATIKELLplvDNVMVMTVNPGFAGQKYLD 151 Listeria monocyt...
AAV79688     97 agahCITLQAEgd--iHLHHTLSWLGQQtvpviggempVIRGISLCPATPLDVIIPILsdvEVIQLLAVNPGYGSKMRSS 174 Salmonella enter...
ZP_00566735  99 agadLITVHAEtg--dDVHPALDTIRQHg---------KAAGLALTLDTPVMAVRPYLdavDVIVLVGTPIGTRGTGLAP 167 Frankia sp. EAN1pec
YP_480902   102 agadLITVPAEi---dDVARALHRIRDNg---------NAAGLALGVDTRVVDARPYLgaiDVLVVVCTPGGARDAALTL 169 Frankia sp. CcI3
YP_519245    83 agvdVVYIHPEse--yQPSATIEKIQNAg---------MIPGIAINPGTSVETITELLkivGRVLVMCVNPGNAGQIYLP 151 Desulfitobacteri...

Feature 1                                 #                                         
1RPX_A      161 SQVKKISDLRKIcaer--glnPWIEVDGGVgpkNAYKVieAGANALVAGS-AVFGApd-yaEAIKGIK 224 potato
2FLI_A      152 ECLEKVATVAKWrdek--glsFDIEVDGGVdnkTIRACyeAGANVFVAGS-YLFKAsd-lvSQVQTLR 215 Streptococcus pyogenes
732069      149 SMCEKIQKVRTAfp------qTECWADGGItlaAAQQLaaAGAQHMVIGR-ALFSSsd-yrATLAQFA 208 Escherichia coli
AAK03364    161 AVIKRITRISNMlgeh--rdqKLISVDGSMnlaLASQLfpLGIDWVVSGS-ALFSQad-vdATLSEWK 224 Pasteurella multocida subsp....
BAB53382    169 KACDRLGAARAIlrgagreaeVALAADGGIrheTVPLLraAGAETVVLGS-LAFGDkd-laGRIGWLH 234 Mesorhizobium loti MAFF303099
ZP_00232911 152 YVDVKIAELVELkkd----ytFEIMVDGAIspeKISKLsqLGVKGFVLGTsALFGKkesyaEIIKKLK 215 Listeria monocytogenes str. ...
AAV79688    175 DLHERVAQLLCLlgdk--regKIIVIDGSLtqdQLPSLiaQGIDRVVSGS-ALFRDdr-laENTRSWR 238 Salmonella enterica subsp. e...
ZP_00566735 168 AAFDRLRTLRGLlhetgrdqaVKILADGGIhqpTVGPLadAGADGVVAGS-LLFGSdd-ltATIRWLH 233 Frankia sp. EAN1pec
YP_480902   170 AALRRLHAARRLveatghqhtVRLLAEGGVgarTVGPLsvAGVDGLITDL-PVLGDdp--aGTAQWLR 234 Frankia sp. CcI3
YP_519245   152 FVHDKICKLLDMqke----ygFEVYWDGHGsveNIRKYapLGVRGFVLGSaTLFGKgrgygEILSELR 215 Desulfitobacterium hafniense...

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