Conserved Protein Domain Family
CIAPIN1
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pfam05093: CIAPIN1 
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.
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Statistics
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PSSM-Id: 398662
Aligned: 58 rows
Threshold Bit Score: 114.29
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5A218                273 KLITPRK--CDislNGGKKRKKACKDCTCGLKELEELEV-SNQQNLQDQILGKlaqsatleaikieerlkqqqqqqqqkv 349 Candid...
ESK93780              202 KKRSTPT--CEpvnPSAPRRKRACKGCTCGLAELEAEELrQSKVVLLDGSESGg-------------------------- 253
EPT03695              202 dreRPEV--CPpvtAGAPRRKKACKNCTCGLAELEAEELkSSKVVLLDGAVDGq-------------------------- 253
XP_006959923          163 APATPLS--C-----PTTKKRRACADCSCGLREQLAQES--QVNIDTSADLpkt------------------------ft 209
EGG08718              196 STNGEVA--CNp-----KKVKKACKNCSCGLRELELMEE--N-------DLPSnlkangstkplt--------------- 244
WGS:AAWC:PGTG_06601.3 248 STMTTED--CNp-----KKAKKACKNCTCGLRELELAQD--N-------DLPAhlkapgselpsqpt------------- 298
XP_014567762          254 EAAQRPEegCDv-----KKTRRACKNCSCGLREILLAEK--D-------DLPdsmsngapav----------ngaasngm 309
KDE05404              231 SLVERED--CNv-----KKTRKACKNCSCGLRELLLQEKddlgaagfaert------------------tgvngaapgvg 285
B6JVP0                200 vLAPPST--CS----KPGKKKR-CKNCTCGQREQDEAEA-AAASAAAPKA------------------------------ 241 Schizo...
XP_013025762          187 NVLRPPE--CE---PAPGKKKRACKNCTCGMREMEQKES-SKASAQLEP------------------------------- 229

Q5A218                350 kVKFTEEDLS-EIDFT--VQGKT--GGCGSCALGDAFRCDGCPYLGLPPFKPGEVVKL 402 Candida albicans SC5314
ESK93780              254 aVEVDQNEKErLIQAAknAPKAT--SSCGNCFLGDAFRCASCPYLGLPAFKPGEKVEI 309
EPT03695              254 tVEVSQSEKErLVAAAaaAPKAT--SSCGNCYLGDAFRCSECPYRGLPAFKPGEKVEI 309
XP_006959923          210 nVQ--------EAQ----AKGAT--SSCGSCYLGDAFRCASCPYLGLPAFEPGQKVEI 253
EGG08718              245 ----------egklgvkgaatVT--SSCGSCYLGDAFRCSGCPYLGMPAFEPGQAVKL 290
WGS:AAWC:PGTG_06601.3 299 --------dpsklvvngsaktFT--SSCGSCYLGDAFRCSSCPYLGMPAFEPGQQVKL 346
XP_014567762          310 kQE--------QVT----TGAVT--SSCGSCYLGDAFRCASCPYLGMPAFEPGEKVQL 353
KDE05404              286 tMG----------------ANVT--SSCGSCYLGDAFRCASCPYLGMPAFEPGQKVAI 325
B6JVP0                242 -VKLTDTM---EIDFTelLKSKNavSSCGSCYLGDAFRCSGCPYIGLPAFKPGEQVLI 295 Schizosaccharomyces japonicu...
XP_013025762          230 -VKLSDTG---EIDFTekLKSKNavSSCGNCYLGDAFRCSGCPYIGLPAFNPGDPIvl 283
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