Conserved Protein Domain Family
GT29_ST3GAL4

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cd23982: GT29_ST3GAL4 
beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).
Statistics
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PSSM-Id: 467710
Aligned: 9 rows
Threshold Bit Score: 342.029
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###                    ##                    #                          
Q11206       116 RCRRCVVVGNGHRlrnssLGDAINKYDVVIRLNnAPVAGyegDVGsKTTMRLFYPEsahfdpkvennpdTLLVLVAFKam 195 human
NP_001076498 116 DCRTCAVIGNGFAlknssLGEIINKYDVVIRLNdAPVRGfeeDVGnKTTLRLFYPEsasynpgihndpdTLLVLVPFKqq 195 zebrafish
OCT72291     181 PCRRCVVVGNGHHlknssLGETINKYDVVIRLNnAPVHKyekDVGsKTTMRLFYPEsadfdpqldnnpdTLLVLVPFKql 260 African clawed ...
CAI29182     111 KCRRCVVVGNGHRlrnssMGDTINTYDVVIRLNnAPVHGyeqDVGsKTTMRLFYPEsahfdpqaennpnTLLVLVPFKpv 190 chicken
XP_007894181 113 PCKTCVVIGNGYNlknssLGDVIDKYDIVFRLNdAPVRGyekDVGsKTTIRLFYPEsavvdpsientpdTLLVFLLFKpa 192 elephant shark
AMB17802      80 YGKQCIVVGNSYNlhnrsLGRIIDSYDVVFRLNdAPVRAferDVGtKTTIRMFYPEsaqsdsvkendntTLFVMVPFKsv 159 Myxoma virus
AUI80711      92 RCKKCIVVGNSHNlvnskLGHKINSHNIVIRINdAPIRNfeeDVGnITTIRLFYPEsaqenakienqkdTLFVMIPFKkg 171 White-tailed de...
OXB80693      80 WCQRCIVVGNGFSvhgqhFGKMIDSHHVIIRLNdAPVKEykkDVGeRTSIRLFFPEsalpnplenndndTLMVFVPFKpl 159 northern bobwhite
ABX60166     104 TCRSCVVVGNGRQilnsgLGSVIDGFDVVIRLNqAPTAGfeqDVGsRTTLRLFYPEsakfppgfspaaeEHLVLMSFKps 183 Chelonid alphah...
Feature 1                                                                            ###         
Q11206       196 DFHWIETILsdkkrvrkgfw-kqppliwdvnpKQIRILNPFFMEIAADKLlslpmqq---prkikqkPTTGLLAITLALH 271 human
NP_001076498 196 DLRWLKEILydekrvqkgfw-kpppqiwlgraSQIRVLDPYFLRITARKFlqipvqpr--kqqkavhPTTGLLAVFVALN 272 zebrafish
OCT72291     261 DIQWMKIILnnekrvrkgfw-kmppiiwevepENIRILNPYYMAVTATQIlkskk--------mtpkPTTGMLAITFALH 331 African clawed ...
CAI29182     191 DFQWMEAILsdrkrvrkgfw-kqppliwdanpEQVRILNPYYMEVTAAKLlslpmkq---prkvkqkPTTGLLAITLALH 266 chicken
XP_007894181 193 DARWLMETLynekrlrkgfw-kappllwhgdpTKTRVLNPYYPHQAATKLlhvplnvppkskkkivhPTTGFIAVTVALN 271 elephant shark
AMB17802     160 DLYWLYNMLtnnarvdlsrfwkkpprtwrarpAFVRILHPKYTYDAALRIqttsg--------tlhvPTMGMVALVTALH 231 Myxoma virus
AUI80711     172 DIYWLYNILnkrrinprlfw-kppiktwdidkKQIRILNPYFAYTAMNLLkdvsk--------ketvPTTGILAIIMSLY 242 White-tailed de...
OXB80693     160 DFLWLREVLlktknktkegfwrqppqewnwniSQLRILNPYVTYEATYKLlqlna-------ssgryATTGIIALNLALH 232 northern bobwhite
ABX60166     184 DFNWLHSVMsgheppadikfwqkvprwwnfpaKRVRILDPYYFQVAGFRLlnvtga-----tydkqrPSSGLLAVSLALH 258 Chelonid alphah...
Feature 1                ##          ###              #            
Q11206       272 lCDLVHIAGFGYPdaynkkQTIHYYEQItlksmagsgHNVSQEALAIKRM 321 human
NP_001076498 273 yCDVVHVAGFGYPasrnqnQPIHYYGQQtmksmknsyHDLNQEAQILHRL 322 zebrafish
OCT72291     332 fCDTVHIAGFGYPaltnkkQPIHYYEKVtlksmavsgHNITLEAQAIKSL 381 African clawed frog
CAI29182     267 fCDLVHIAGFGYPdsankkQTIHYYEQItlksmaaseHNISHEAVAIKRM 316 chicken
XP_007894181 272 yCDEVHIAGFGYPlnq-nnFPIHYYSKTtmkemansgHNVTHEHLFLRKL 320 elephant shark
AMB17802     232 vCQGVTITGFGYPngg-pnQFIHYYNGYtmramqnsiHDVNAEKTIIERM 280 Myxoma virus
AUI80711     243 mCNYVSIVGFGYPdn--syTPIHYYNNStlnnmvstiHNLNSEYILIQKL 290 White-tailed deer poxvirus
OXB80693     233 lCQEVNIAGFGYPgnhdttTPIHYYNTGlsrrnelfqHNLTAERNWLLKM 282 northern bobwhite
ABX60166     259 hCDRVAITGFGYPdsgdssAWVHYFDAAllkdtssvpHDFPKEKKVLQQL 308 Chelonid alphaherpesvirus 5

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