Conserved Protein Domain Family
DUF2465

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pfam10239: DUF2465 
Protein of unknown function (DUF2465)
FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.
Statistics
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PSSM-Id: 463016
Aligned: 35 rows
Threshold Bit Score: 308.023
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011231417         15 GFSGAQSLGASC--PHFRALCARLAAELATLG-ALErergesaEALRAGDGPGEEDEFLRQLAGLLRELHCPDRALCGGD 91 
EFX83447             24 QMARLLERNDPGyiVDLSKVVNFLSLKLGSLC-QLE-------DLVNAIEKPEEGEMFCMELAGLLRELYCPYSVLMDGP 95 
6_pfamImport          1 GLRAAVAEGLLT--KEYTECVEWLSKELQYFC-KLD-------EHVNAISSPDDIPSFLLEVSSFLKELGCEYKSLTEGK 70 
XP_971123            23 SFDSALQEGAKN--VEFTKLVSFLTNELRALL-NID-------EEVNPISGPEDSVSFVMEVSSFLKELNCPYVALTQGH 92 
EDS44247             20 LDAATLGGGISQ--PGYRALIQWLTAEIRRYG-ELDd------ESVCSV---DDEVCFRWELSSFLKELGCPYGALMDVP 87 
Q16TF4               22 SLEGIQSAGLSN--RNYRDLVCWLTQIIKQYApEVD-------ETVSSV---DDLHSFAMEISSFLKELSCPYHRLLDGP 89  yellow f...
WGS:AANI:GJ24672-PA  23 TLCQALDSGIGS--GDLREVIYWLADQLHVLR-KTD-------EHVASSS--KDHNEFAFELSLLLTELGCPYRQFVAVP 90 
Q9VBK9               26 NLSRALDAGIES--PDMQEVVLWLAHELHILR-KTD-------ERVN--QGKALNKDFSFELSLLLTELGCPYRELVQGP 93  fruit fly
XP_001954356         25 NLSRALDAGIES--PALRLVIHWLAQELHVLR-KTD-------ERVS--SGSGDHDEFSFELSLLLTELGCPYRKLVIGP 92 
WGS:AAQB:GK12865-PA  25 NFCKAVDEGIDS--GDLRDVIFWLANELHVLR-KTD-------ERVTSSG--KDHDEFAFELSLLLTELQCPYRQLVIGP 92 
XP_011231417         92 GAAALREPGASLRLLRFLCSELQAARLLRLYprldpspAPLCGEGAEEGAGMVQELVLTLQALGLP-R-PTPGTAASRLL 169
EFX83447             96 PVARLTNRENRFKLLNFLISECQAAMMNNLE-------NQLEKCSLKTETPTAEKLKSALMTLGFS-K-PPSDISAKQLF 166
6_pfamImport         71 VGERLQSTNDRLKLLDFLITELLAARILSAKk------pSTNVELCINESPTAATLKKLLMTLGFP-K-PPATITANMMF 142
XP_971123            93 ISDRLESHQDKLLLLDYLATELMAARVLQEKk------pDKKFELKLQETEEAANMRKILMTLRFH-K-PPPNITIPQLF 164
EDS44247             88 LTERFREGGDARMLVEYLVGECAALAMVRRQrd----qEERRFQVSVLEPCTEGDLLNICGALGLS----VENLRADNIF 159
Q16TF4               90 LSSRYRSEEDSLLLIEFLAAECVTGVINQQKrn---eeMKHQIDLVQHPGTPLSTVMQMFQLLDLDvNsMGTDITDSETF 166 yellow f...
WGS:AANI:GJ24672-PA  91 MSERFQTRTSLLHLLDYLTSELMATKMSLKLq-----pAEPPSKKSKTESHLQETVTQLTADLQLG-E-LPKNINTKQLF 163
Q9VBK9               94 IEQRFKSRMALVQLLEYLTSELMTTKMVLKAq-----pVGPPCKRSKVDTNVQQVVENLAKDLQLG-E-VPKNINTKMLF 166 fruit fly
XP_001954356         93 IEERFQTRESLVQLLEYLTSELMATKMVLKAq-----pVGPPCKRSKTESNAQQAIEQLAKDLQLG-E-LPKNINTKLLF 165
WGS:AAQB:GK12865-PA  93 IAERFQKRDSLLQLLEYLTTELMATKMSLKTqr----sIEPPTKKSKTESNIQQKILELSRDLNLGvD-LPKNLNTKMLF 167
XP_011231417        170 WQLHDKISELLPSLPPGFL-QP--LL--SFPLDAPRWEALESLCQRLGDQYCCRRCLLLKRLDLTASSFHWSDRAEAQGE 244
EFX83447            167 NKMGVKIREILSTAPKDYPgSP--LL--KTSLAEQQWSQLHQLLGELNKDYKLRREMLLTRLDVTVLSFTWSPNVKSKMD 242
6_pfamImport        143 SKRCPNPIPKLEEISNKCVsAP--LF--KGVLSPKQWETMEQMQKDLHEEYTVRRELLLKRLDVTIQSFQWSERMKGREN 218
XP_971123           165 QKVCPTVQSIVQKVGSELVgKP--AF--QGTLSDKQWETLNGVQKDLNNEYKIRREMLLTRLDVTIQSFQWSDKTKGKDE 240
EDS44247            160 NEINQRLND------EPLIgGP--VFrpEVNLTAGQWVRLERTQAELLAEYSLRQQMMLKRVDLTMAAFQWKGKDG---P 228
Q16TF4              167 NRIIHRLKEFFATD----FnAPdlLFvpKTNLNEAQWAQLDQCHTDLQEEYNLRRQMMMTRLDVTMLGFQWKGDTK---L 239 yellow f...
WGS:AANI:GJ24672-PA 164 ERLTPKLEQRLKQTSPAVIsEP--LMrtNKPLTDAQWRVLESMHRDLDAEYNLRRQMMLTRLEATVQSFQWSESMKKRQG 241
Q9VBK9              167 EKITPRLEQAIKKTNPQVLsEP--LLklKKPLTDAQWQLLETLHRELEAEYNLRRQMMSTRLEATVQSFQWSESMRQRSN 244 fruit fly
XP_001954356        166 EKLIPTLDQSLKKTNRQVVsEP--LLnlKKPLNDAQWRVLESLHRDLEAEYNLRRQMMTTRLEATVQSFQWSESMHQREN 243
WGS:AAQB:GK12865-PA 168 DKFTPRLEQLLKQTNPKVVsES--LLdpNKPLSDSLWRLLETMHKDLDGEYNLRRQMMLTRLEATVQSFQWSESMHNREN 245
XP_011231417        245 AMKAVLIPIREALTPES----DVSIAHILAARADLSRLVPATSKAARRGTCCAINKVLMGNVPDRGGRPNELEAP---MP 317
EFX83447            243 EVSAIFQPLRSSMLAEP----NVNISRLLSAREDVAYEEKTSSASVREKTKTPLQRMLIGEVPDRGGRATENRRPppeMP 318
6_pfamImport        219 EIATMFSSKRNALTAIP----DVKLSDILAARYHLAIMEKTSNANVRKNTQSSVNKVIIGRVPDRGGRPSEQQPPppeMP 294
XP_971123           241 LFEKVYTEKRKRLKTEP----EVELADLLAARDDIAIIEKTSNSSVRKNTKSSLNKVIIGQVPDRGGRTSEQAPPppeMP 316
EDS44247            229 AVAQTYRKWRRHLVDLIesfsTADISTLLAADEEVLRQERVSSTRLKGTGKNAFQGYLT--LPTGGGVVKIDEKPa--MP 304
Q16TF4              240 DVAQIWRQKRRNLDALTtnlnRRDISDLLVAERSLLTMEKVASTRIKGSKKNVFQGNLT--LPNRGGVVSINAKPh--MP 315 yellow f...
WGS:AANI:GJ24672-PA 242 EIGDRFQRKLKEIEKLQyggdDTNIVALLAARADLAIIEKTSSANVRKNTASKIEKHVIGNVPDRGGRANEHAPPppeMP 321
Q9VBK9              245 EIMDRFNRKMRELDQFKvggkQTDLVALLAARSDLAIIEKTSSANVRKNTASKIQKHVIGRVPDRGGRANEHAPPppeMP 324 fruit fly
XP_001954356        244 EIMDRFQRKLRELEQFKvggeQTNLVALLAARTDLAIIEKTSSANVRKNTASKIQKHVIGSVPDRGGRANEHAPPppeMP 323
WGS:AAQB:GK12865-PA 246 EIVSRFQNKLKELEQLRyggdDTNIVALLAARKDLAIIEKTSSAQVRKNTTSKIQKHVIGRVPDRGGRANEHAPPppeMP 325
XP_011231417        318 SWQSRRE 324
EFX83447            319 GWQKRKP 325
6_pfamImport        295 SWAPRAA 301
XP_971123           317 SWQQ-RT 322
EDS44247            305 NWSSREE 311
Q16TF4              316 VWSSREE 322 yellow fever mosquito
WGS:AANI:GJ24672-PA 322 SWQQQRA 328
Q9VBK9              325 SWQQQRA 331 fruit fly
XP_001954356        324 SWQQQRA 330
WGS:AAQB:GK12865-PA 326 SWQQQRA 332
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