2GUP


Conserved Protein Domain Family
ASKHA_NBD_ROK-like
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cd24152: ASKHA_NBD_ROK-like 
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family
This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Links
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Statistics
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PSSM-Id: 466988
Aligned: 37 rows
Threshold Bit Score: 229.762
Created: 10-Apr-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:DClick to see conserved feature residue pattern help
Evidence:
  • Comment:A strictly conserved catalytic aspartate residue that serves as a Schiff base during phosphoryl transfer.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2GUP_A         5 TIATIDIGGTGIKFASLtpdGKILDKTSISTpen-------leDLLAWLDQRLSEQd---------ySGIAXSVPGAVNq 68  Streptococcus p...
CDD23876       3 TVVSIDIGGTNLRVGVVdekLNIINVLREPTtkd------dnsLLYNQIKRMLSEVlntlpegtslpKTCGVSACGLVS- 75  Firmicutes bact...
EUJ21389       2 ADLVFDLGGTTVKQALVnssGELSFKKVQSTprn-------ylDLLDYLEKASHNHqa--------aRAIGLSVPGIYNq 66  Listeria aquati...
AHI53814       5 LILCFDIGGLGLKVSLYdldMNEKFRTKFTYkll------ekkTIFDLIKNTYQEVgkd-----fdiTAIAISASGIIDa 73  Spiroplasma sab...
WP_026389173   1 MKLCFDIGGMSVKAAVFdgqEMVNKKDYVYGkai------nnvELLEILNNALKEAieky----pqiDGIGISSAGVIDt 70  Acholeplasma mu...
WP_033161320   3 YILAFDIGGTNIKYAIIddnFNIINSYIIKTkt---------kSLLEQIENIINSVdy-------kfKTIAIATTGVVDd 66  Mesomycoplasma ...
WP_067422623   3 IVCCFDLGGTTINCAQFdlaGTIQEFETLPSk-----------NDKEYILDTINTYlnqvv-qshklVGIGLSVPGMVDv 70  Erysipelotricha...
WP_100609026   1 MILTFDIGGTATKIALFdtnHSLIKTDIIDYhealiesailkqLIKEKIALFQSNFv---------iTALSFATCGVVNa 71  Entomoplasma fr...
AVP48984       1 MNLVLDIGGMSTKIAICdnnNKFIYRHNFSYpnlisi-dvlvrELEQRIFDIILTNk---------iDNICISSPGNVNp 70  Williamsoniipla...
WP_119866054   3 KYLAFDIGGTNLKYGIVteeAELIYKKIIKIqdt-------ykELVDYICKIYDETdd-------ieEVIGISCPESYNk 68  Clostridium isa...

Feature 1                                              #                                         
2GUP_A        69 eTGVIDGf-SAVpy-ihGFSWYEALSSy--QLPVHLENDANCVGLSELLAHpe--lENAACVVIGTGIGGAXIINGRLHR 142 Streptococcus p...
CDD23876      76 -NNHIDN--LVNlh-ilDFDLKGLLENdfpFLKVYIANDANCAAFSEATLGsaknySTSFFMTVSTGIGGCLVYNQELID 151 Firmicutes bact...
EUJ21389      67 vKKILTGs-SAIsy-iiGKPLVVDLQKr-vQKPVFIENDGNCALLGELWLGsakgiQNVAMYVIGSAVGGAIAIQGNILH 143 Listeria aquati...
AHI53814      74 kNKLMYSlkDSNsk-liQDDLHGYMKWc--TIPWFIENDANCALLAEKYFGaaqskKNICLITIGTALGGALMINEKIYV 150 Spiroplasma sab...
WP_026389173  71 eTTQVHGr-AAIed-ikYINFRRDLET---SLPVFAENDAFAAAQSQIAFNkevegKNTIVMIIGTGLGGALILDDKLYK 145 Acholeplasma mu...
WP_033161320  67 iKKEIIHa-GNNlnylkGTNFSYLAKKf--NKNIVVENDANAAIYAELINNkhqniNNIALITFGTGVGGGILINKKLFK 143 Mesomycoplasma ...
WP_067422623  71 eRGVVNGf-SALqn-lhEFNYISYFHEl-yNVPVVIENDANAALLGEYYNGhakdkDNAILISVGTGIGGALMESKNLVR 147 Erysipelotricha...
WP_100609026  72 -NGTISGl-SAIln-yeGFNWKKELSCy--NLPISVENDANCSLVAENQYGsaqgyQNIITMVLGTGIGGALMINGKLLN 146 Entomoplasma fr...
AVP48984      71 vSGEIKGl-SAIqg-leTFNFKLTWEPk-fKLPVFIDNDANCAAIAELEYGnakneKNVVVIVIGTGVGGSLIIDGKIHR 147 Williamsoniipla...
WP_119866054  69 eKKIIEGs-SALsy-iiGEDLLGDIKKk-vNAEVIIENDGNCSLLGEIWNGkakgkKNVALFVVGTAIGGAICIDGKIIK 145 Clostridium isa...

Feature 1                                                                                        
2GUP_A       143 GrHGLGGEFGYXTTLAPaeklnn--wsqlasTGNXVRYVIEKSGhtd--wdGRKIYQEAAAGni--lcQEAIERXNRNLA 216 Streptococcus p...
CDD23876     152 L-PFEIGHMTISYKGKFheve------rllsGNGIVNLCSINGLki---snAGEFFKKVKDKdn--evLKVYDEWIKQLG 219 Firmicutes bact...
EUJ21389     144 GaNLNAGELGYELIANNpaddsfqtlggrigFQAVLKDAEQQFGle---knGEILFEVMKQNqe---vKEFYQQRMDYLA 217 Listeria aquati...
AHI53814     151 GsHFMANEIGCGILDNNftnfkn--isvqtgMNGLVEEYNSVYNkn---leGIDILKLAEKDsls-keYQIVKSRLVKIA 224 Spiroplasma sab...
WP_026389173 146 GsNLLGGSFGFIAHDINfatlsi--ghntatTGMLIKGHHDRTGel---ltGKEIVEGYNKDeq---kKISVDKFVEDVA 217 Acholeplasma mu...
WP_033161320 144 GnNFLGGEVGSLFLTNSnadkel---sfskfNEKIIKKFNFSSK-------DSEIFLKQYSNnl--efKNYLNKYLNKVA 211 Mesomycoplasma ...
WP_067422623 148 GrKNLAGEFGFMLQHQKentyvs--lneltsLALLVKRINQEDYiti--tsAKEAFDLAESGdg--diKKIIDDFYRNLA 221 Erysipelotricha...
WP_100609026 147 GlNGEFGCFLASNHVNEpyqnl----sqvasPRNVEKRLNDLLAsqgeqqkLENYFQAYDKQlepqkeFAYLDEMLFNLA 222 Entomoplasma fr...
AVP48984     148 GnHFFAGEYGYLLNTKYgndryln-vsqsigIANLIQSFKKRTNke---vnGEQIYDLYNTDnd---aKTVVEEMIHNTS 220 Williamsoniipla...
WP_119866054 146 GvNNSAGELGYMLLRNDvknmnfnslgglssVGGIVEKTREVHKgki--tnGIELFNEFDKNkq---lKKAVEEYITYLS 220 Clostridium isa...

Feature 1                                                                                      
2GUP_A       217 QGLLNIQYLIdPGVISLGGSIs-QNPDFIQGVKKAVedfvda---------yeeytVAPVIQACTYHAdANLYGALVN 284 Streptococcus pne...
CDD23876     220 LLIANLQMMFaTDCFVLSGGVmkSADIFTADLKEIVnafla-----------pysiKKINFVQAEFGQdAGLMGGASI 286 Firmicutes bacter...
EUJ21389     218 ASIINLQYILdPDIILIGGAVs-ENPFFIQMLQDSLerilrh---------rphhkVHPKILPAQFFNdANLLGASYH 285 Listeria aquatica...
AHI53814     225 QVIINMYFTVdPELILIGGGVs-ANSWYLEELKKTIkeiea----------ivgvpILAEIKSCQFQNdAGKIGALAL 291 Spiroplasma sabau...
WP_026389173 218 KVVISANAVAdAELVLIGGGIs-QSDLILDLVTKRIdafldv--------vgepykRKFAIQRCVYAQdANLYGALAL 286 Acholeplasma mult...
WP_033161320 212 KFLANLSIIYnLEIIKYGGGLshLDNIFLEKIEKRFyfll------------nktaFKTQIFLADNKNdSGMLGISYL 277 Mesomycoplasma co...
WP_067422623 222 VGIYNLNFSFdPDVILLSGAIs-ERSNFDQQLQNHVnqlidesverflgkhvdskwLYPIIKACKNGNkSNVIGMYSK 298 Erysipelotrichace...
WP_100609026 223 KTIVNISFTItPEIFLIGGGIs-ANQIFMKHLQKYVtriya----------dlgmpLTFSLKAATFKNeANLHGAYFL 289 Entomoplasma freu...
AVP48984     221 KLIYNLSFIIdPDLILIGGAIs-KNILFINLVNKELktlyk----------kiglePQFLIKSCKYYNdSNLIGANML 287 Williamsoniiplasm...
WP_119866054 221 LACINIQYIIdPEVIIISGAIs-SNDKYIDILKEKVdeilki---------ktfhkIKPTIVKAILGNdSNLLGIVYK 288 Clostridium isatidis

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