Conserved Protein Domain Family
SCIMP

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pfam15050: SCIMP 
SCIMP protein
This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Statistics
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PSSM-Id: 434419
Aligned: 10 rows
Threshold Bit Score: 211.987
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005337454  24 MILWINYFWIILAVAIIVVSLVLGLILYFVCRCQLRQGKKWKISKSMKQiHGDEEEKMYENVinQSPDQLPPLPPRDLHF 103
EHB13545       5 MSWWRNYFWIILAVAIVVVSLVLGFLLYCVYRWQFKQGKKWEIAKPLKQ-NQREEEKMYENV--QSPDPLPPLPPRGSFS 81 
XP_001080739   1 MSWWRNNFWLILAVTIISISLVLGLILYCVCRWQLRQGRNWEVAKPSIQ-DGREEDKMYENVlnSSPGRLPALPPRSSPF 79 
Q6UWF3        12 MSWWRNNFWIILAVAIIVVSVGLGLILYCVCKWQLRRGKKWEIAKPLKH-KQVDEEKMYENVlnESPVQLPPLPPRNWPS 90  human
XP_016284855   1 MNWWLKHFWILLASTIILVSVTMALVLYCICRRLLRQGKNWKITKSWKH-NNKDREEVYENCinGMPVSLPPLPPRNVPS 79 
XP_005619963 130 MDWWRDNFWIILAVAIIVVSTGLGLILYCACRQLLRQGKKWEIAKPLEE-KRRDDEKMYENVnnEPLVQLPPLPPRGLLF 208
XP_003358266   3 MDWWRDNFWLILAVAIIFVSAGLGIILFCVCRRLLRQGNKWAVAKPLKQ-QQRDEEKTYENVtdQFSVQLPPLPPRGMLS 81 
XP_006102841  20 MDWWRDNFWIILAVAIIIVSVVLGLILFCICRRLLRQGGKLHIARPLNQ-RLKDEEMMYENVidQSPGQLPPLPPRGLLS 98 
ELW63663       1 MSWWRNNFWIILAVTIIVVSVGLGLIMYCVCRWQLRQGKKWKIVNSLKQ-NERDEEKMYENVpdQSPDQVPPLPPRGVFL 79 
XP_002719054   1 MSWWRDNFWIILAVAMIIVSVSLGLIMYCIYRCQLRQGKKWEVVRPLKQ-NRRDEEKTYENVfnQSPTELPPLPPRGLPS 79 
XP_005337454 104 LGD---SSLQEIpaqsPPMYSSVNKVRNKKPVSSLGYTEPEDDYDDVEIPANTesH 156
EHB13545      82 QGN---FAPQEI----PATYSLVNKATNKKTVPTLSYIDPENDYDDVEIPGNT--Q 128
XP_001080739  80 PED---PAPQESprqpSAWYSSVKKVKKKNVFDISVSTDPENDYDDVEIPATTeiQ 132
Q6UWF3        91 LED---SSPQEApsqpPATYSLVNKVKNKKTVSIPSYIEPEDDYDDVEIPANTekA 143 human
XP_016284855  80 SEAiahDSQHEDks--qiSYSTIMK----KRVSIPSYIEPTADYDDVDIPTNLgfH 129
XP_005619963 209 PEH---TFPQEPpsqpSSTYSLVNKVRNKKTVSIPSYIEPLDDYDDVEIPANMekQ 261
XP_003358266  82 PEK---TSPQETpslpPAAYSSVNKVRNKKIVAVPSYVEPENDYDDVDVPARMenH 134
XP_006102841  99 QQD---ASPQETrsepPPTYSLVNKDRHVKTVSIPSYIEPEGDYDDVEMPAAMesH 151
ELW63663      80 PQV---SSPQETlsepPVTYSLVNKVRKKKIISIPSYIEPEDDYDDVEIPAEQvyL 132
XP_002719054  80 LGD---SSPQETpslqPPTYSLVN-MRNKTATS--SYVEPESDYDDIEIPANTegH 129
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