Conserved Protein Domain Family
TFP_LU_ECD_Ly6D

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cd23542: TFP_LU_ECD_Ly6D 
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins
Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Statistics
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PSSM-Id: 467072
Aligned: 15 rows
Threshold Bit Score: 73.9885
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q14210        16 GPALTLRCHVCTSSs--NCKHSVVCPASsRFCKTTNTVEplrGNLVKKDCAES--CTPsytlqgqvssgTSSTQCCQEDL 91  human
XP_020850661  16 GQAQALQCHVCESAd--NCKKAILCPGSsHFCKTTISFQrlsGNLVKKECADY--CAAqnsd---agqtQPQIRCCTTDL 88  koala
XP_007488482  16 GQVRALQCHVCESSd--NCKKQVTCSSSsRFCKTSINYQslsGNLVKKECVEN--CDPqn-------geQYKILCCSSDL 84  gray short-tail...
XP_028919518  10 PAAHALKCYVCENSs--NCKTEKVCSPSaRYCETVTSYNplnGNLIVKRCSET--CFGknet---hqgtITRTTCCHTDL 82  platypus
EMP26634      96 GIAYSLHCHVCNSTtvnTCTNPVNCSTAdRYCTTFIRNSstpDYLLEKRCSQT--CPLstmmk-tlvmpQSSFLCCQEDL 172 Green sea turtle
XP_020850645  49 TSLVRLQCHVCMGDf--QCQAPQTCAPTeKFCMIAQTDKn--EYNVIKYCAET--CPYmerfh-grsegDGYLACCAQDL 121 koala
NP_001371082  16 SLARALHCHVCCGHe--NCESLVECALTdKYCVITRATNp-gGILVMKSCAPT--CPNstvs---sdgrALSVSCCQGSQ 87  Mus musculus
ELW63428     104 LAARALHCHVCCGHe--NCESLVECAPTdKYCVITRATNp-gGILVMKSCAPT--CPNstvs---sdgrALSVSCCQGSQ 175 Chinese tree shrew
NP_001232875  55 QAPNGRSCYSCDAN---SCSVKVNCEGSeDRCISASVTQg-tNTISVKGCVSNsfCAAsgsts-tsgigITSMQCCEGNL 129 channel catfish
KAB5546706   142 QPINGRKCYTCNEN---DCSRTLHCEGAeDCCITATVAQg-pNVMSLKGCTTKnvCNTtllra--hgliITDVECCEGNM 215 striped catfish
Q14210        92 CNEKL 96  human
XP_020850661  89 CNAGI 93  koala
XP_007488482  85 CNSKT 89  gray short-tailed opossum
XP_028919518  83 CNSRV 87  platypus
EMP26634     173 CNGVG 177 Green sea turtle
XP_020850645 122 CNYKR 126 koala
NP_001371082  88 CNRSA 92  Mus musculus
ELW63428     176 CNRSN 180 Chinese tree shrew
NP_001232875 130 CNGAE 134 channel catfish
KAB5546706   216 CNSAE 220 striped catfish
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