6H25


Conserved Protein Domain Family
MPP6

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pfam10175: MPP6 
M-phase phosphoprotein 6
This family represents the M-phase phosphoprotein 6 (MPP6) which is involved in the generation of the 3' end of the 5.8S rRNA precursor. MPP6 is required for the integrity maintenance of the rRNA processing complex as it mediates the interaction between MTR4 (RNA helicase) and RRP6 (an 3'-5' exonuclease), and the recruitment of Nuclear VCP-like 2 (NVL2) to the nuclear exosome.
Statistics
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PSSM-Id: 462978
Aligned: 45 rows
Threshold Bit Score: 45.4932
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6H25_K        14 KLSKNLLRMKFMQRGLDSETKKQLEEEEK-----------------KIIS--EEHWYLDLPELKEKESFIIE-------- 66 
CCH62887       4 KLSSSVKSMKFMRFANGESEQSVEMSSNEap--------------qPKYAhdNSNWSLAPRKTEKSGNNKAKkvriik-- 67 
XP_003957809   7 KLSNRVMNMKFMKFSNDDASTTSADSSRSasvn---------srtnNSKFhdNSEWYTTNSTVTNNDPKKKItkkflkk- 76 
CCK69799       6 ALSSRVMNMKFMKFGASASAGASASAGASaegtsstatedggstgsSSAEnaGQQLAQQHRTQEQFTVTLPAgvsrrtks 85 
XP_002551736   8 KLSSRVMNMKFMKQADQAEEIEQEKQKV-------------------QHHvdTSEWALSGGEEFKSRLRP---------- 58 
Q6CTZ1        12 KLSNRVMNMKFMKHAEQADKVKQTEETI-------------------KKLvdSSEWRIGDNVKLLTKLANKSk------- 65  Kluyveromyces l...
XP_002546217   5 GLSNRVMNMKFMKKAEDNQISKQRKEEQ-------------------KKIhdLSEWIMPNSDKLLKLASMKP-------- 57 
XP_011271229   7 GFSKNVLNMKFMKQAEKRAEEQDEEQQE-------------------SKLkdLSEWKTSNAEKLKQKAQAKP-------- 59 
CCC67013       7 SLSSRVMNMKFMKFSRNNNNNDEENTSDSressin-----nndetsNKNFrdNSEWKLEPNTTPIKGKKVIRikkknq-- 79 
Q6FIY3         6 ELSSRVMNMKFMKFMRPEGQDNKDEGTSK------------------HTHldASKWDLKSSVNSDSTNKRRVvvkra--- 64  [Candida] glabrata
6H25_K        67 ---------EQSFLLCEDL------------------------LYGRMSFRgfnpevekLML----------------QM 97 
CCH62887      68 ---tktrysKPMNVGITTIsrvaq---------------essfVRGRRVIEttnp-telEN------------------K 110
XP_003957809  77 --kpmmnkvVTSNVSFTTLkqgktvade-------dtihmktlNKGRMVFGd---------------------------- 119
CCK69799      86 lqvrrrrpvVLSNASYTDLnrg------------------mlnMEGRTTFGap--------------------------p 121
XP_002551736  59 ---------QLRTAGTTEImeqt----------------qsapVVGRRKFGsqaktepeGTTepgldelwenqkgkkrKA 113
Q6CTZ1        66 ---------VVQNVGFSAIkslndedskidtndlststlrtsvNAGRRIFG--------NKLgra----------tpgSD 118 Kluyveromyces l...
XP_002546217  58 ---------KIETVGYGNImsssny-------------nysstTSVRKTWGdv--------------------------n 89 
XP_011271229  60 ---------KVIAVGFTALnsln----------------ngppVIGRRTFG----------------------------- 85 
CCC67013      80 ---lrshpnVIQDVGITYIqsnl-----------------nnaIMGRQTIRddke-tenEKDn---------------KE 123
Q6FIY3        65 ----skalkIMENVGITSVkaedds-------------nkssaLHGRRIFG--------EN------------------K 101 [Candida] glabrata
6H25_K        98 NAKHKAEEVEDE-----TVELDVSDEEMARRY-----ETlvg--------tigKKFARKRDH 141
CCH62887     111 KRKAESEASDQNklvteDEDDYVPDDNLDTLF----------------------KKGNKKQK 150
XP_003957809 120 -KKRTAEEEKLQ-----ENENDDDDYELDKMFk-------------------aSLKKNKKSK 156
CCK69799     122 kRAREEDEAGQG-----WKDADADGYDLDKILketatSKd------------tTKKSKKTKR 166
XP_002551736 114 GEAAGEKDEKET-----DQSEDEEEEAPAKRFksqqeKT--------------DKRERKSSK 156
Q6CTZ1       119 GSSNDKKRSFEE-----KDEDDVSTTDLEKLWea------------------eTQTKKQKKS 157 Kluyveromyces lactis
XP_002546217  90 kAKLAVEEITDDkkpvdADDDDEPPLDLNTMWkkrklE---------------SSSKSNKKK 136
XP_011271229  86 ---ETKKEEKKP-----EQEQEGKVNDLDKLWqkqkeERsepksgkrskdeipKKTQNKKRK 139
CCC67013     124 NENENQEHTKRP-----RDDEPEDDYDLDKIFkesmsKNk-------------HNNKKQKKN 167
Q6FIY3       102 NKRVAEEEEENK-----TEQEPKQEKDMDELFkesrrNTk-------------PKKKSHKKH 145 [Candida] glabrata
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