1XRS


Conserved Protein Domain Family
Lys-AminoMut_A

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pfam09043: Lys-AminoMut_A 
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D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit
Members of his family are involved in the 1,2 rearrangement of the terminal amino group of DL-lysine and of L-beta-lysine, using adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate as co-factors. The structure is predominantly a PLP-binding TIM barrel domain, with several additional alpha-helices and beta-strands at the N and C termini. These helices and strands form an intertwined accessory clamp structure that wraps around the sides of the TIM barrel and extends up toward the Ado ligand of the Cbl co-factor, providing most of the interactions observed between the protein and the Ado ligand of the Cbl, suggesting that its role is mainly in stabilising AdoCbl in the precatalytic resting state. This is a TIM-barrel domain.
Statistics
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PSSM-Id: 401110
Aligned: 30 rows
Threshold Bit Score: 820.695
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XRS_A             5 LNLDFNLVEKARAKAKAIAIDTQEFIEKHTTVTVERAVCRLLGIDGVDTD----EVPLPNIVVDHIKENNGLNLGAAMYI 80  Acetoanaero...
WP_025357841       4 LDLDGEVVGRARALAARAAEPVITLARAHTTVAVERATLRLAGITGADTThragDVPWVNRVVDTIREHCGLEHGAVLPA 83  Kutzneria a...
Q67TH1             5 LNIDPARVARARELAGRIVDQVQPFIERHTTTAIERAVVRLFGVEGKGPD----DVPLANLVVESLQDGGGLDRGAAYWL 80  Symbiobacte...
CCH88060           4 LELDGELVRRARELAARAAAPVVDLARTHTTVSVERAVLRLAGLTGTDPVlgdgEVPWVNRVVDAVREQVGLEHGVALPV 83 
SIPI:L083_3927     4 LGLDPVVVARARALARQAGQAVVQLARSHTTVSVERAVLRLAGVRGADPD----GIPWVNRLVDVVRADVGLEHGVAVPV 79 
WP_013019173       7 lPLDDGTIDRARKLARRAGQPVVDMAKSHTTVAVERTVLRLAGLTGADGD----GIPWVNRLADAVRSDVGIEHGVALPV 82  Stackebrand...
jgi:Kfla_3602      8 LDLDPVTVRKARSLARKAGRPIVNIARQHTTVSVERAVLRLAGLAGADTE----GIPWVNRLADTVRADVGLEHGLALPV 83 
CAN93048           4 vpVEQEKVEACRAFAADIADEVQRFIDRHTTVGVERTVARAYGVVGADAE----GTPLVNALVDRIHRAGQAGRGVAYHL 79 
mpitm:STAUR_4748   4 pfiQDEQIARARQLAEEIVHPIFELIRRNTTVSNERTVLRFFGISGAGAR----GVPLANLMVDKLKGSGVLNRGAAYWY 79 
Q2IHX5            12 LHLDRAQVERCRALADRITAPVLEFVGRHTTVSIERTVLRLFGLHDAGPR----GVPLVNMAVDALHEKRLLHRGAAYWM 87  Anaeromyxob...
1XRS_A            81 ANAVLNTGK-TPQEIAQAISAGELDl-TKLPMK--DLFEVKTKALSMAKETVEKIKNNRSIRESRFEEY-GDKSGPLLYV 155 Acetoanaero...
WP_025357841      84 FHALREHDLgSLTELAEATAAGQVR--FTVPTGk-QAERAGRAARTAVAKGLRTVDRNRAQRDKLVARLgDPARRPWIYL 160 Kutzneria a...
Q67TH1            81 ANACTQTGR-TPRQVAEAVAGGELDl-MQLPRL--PEEEIRAEAERLARMALDRIRQNRRTREELIGRY-GERPAPWLYL 155 Symbiobacte...
CCH88060          84 WHALGRDG--SLQELAEQVGAGTAR--FSIPA---DPEPARDAARAAVAAGMARIDANRARRDELVALHgDPPRRPWIYL 156
SIPI:L083_3927    80 FDALVREQAgDVTALAQAAAGGAVR--FRVPDRraEVVAARRAASRATAAGLRVIDRRRRERERLVARVgDAPRRPWIYL 157
WP_013019173      83 FHALVSEGHhDLTMLAHKAAAGSLH--FSIPTGk-DAEAAKEAARIAVSGGIARMDAARAQRDQLIDEVgNPKQRPWIYL 159 Stackebrand...
jgi:Kfla_3602     84 WDALVRGEAeDLSVLAQKAASGSVT--FRLPEGr-DAVRARAAARKAAAAGLKRVDARRRERDRLIKRHgDPEQRPWIYL 160
CAN93048          80 GRALCEGAG-SVQEAAEMLAFSEAAdlGAGPSA----AEARGALEAATREAIARIDRARDEREATKAAH-RVGVAPLKYV 153
mpitm:STAUR_4748  80 GRALQLGAK-SPLEAVERLTALPVEklGPLSPE--MEQNLRAEVRAEARAAMEDLQSRIAQRNALRKQF-PMSPPPHKYV 155
Q2IHX5            88 GYVMRRGAT-DPLAVVERMAALPADp-EPLPPA--EEQALLAEMRAEARAGVDELLGRVKARDALRGEL-GVGPRPHKYL 162 Anaeromyxob...
1XRS_A           156 IVATGNIYEDITQAVAAAKQGADVIAVIRTTGQSLLDYVPYGATTEGFGGTYATQENFRLMREALDKVGAEVGKYIRLCN 235 Acetoanaero...
WP_025357841     161 IVATGDIDEDVVQACNAARAGADVIAVIRSTGQSLLDYVPEGATHHGFAGTYATQENFRIMRAALDEVSKEVGRYVRLTN 240 Kutzneria a...
Q67TH1           156 IVATGNIYEDVVQAQNAARQGADVIAVIRSTAQSLLDYVPEGPTTEGFGGTFATQENFRIMRRALDEVGAELGRYIRLTN 235 Symbiobacte...
CCH88060         157 IVATGDIYEDIPQAQAAARAGADVIAVIRSTGQSLLDYVPEGATRTGYAGTYATGENFRLMRAALDDVSAELGRYVRLTN 236
SIPI:L083_3927   158 IVATGDIHEDIPQAQAAARAGADVIAVIRSTGQSLLDYVPEGATTEGFAGTYATQENFRLMRAALDVTSRELGRYVRLTN 237
WP_013019173     160 IVATGDIYEDIPQAQAAARAGADVIAVIRSTGQSLLDYVPEGATREGFAGTYATGENFRLMRAALDETSRELGRYIRLCN 239 Stackebrand...
jgi:Kfla_3602    161 IVATGDIYEDIPQAQAAARAGADIIAVIRSTGQSLLDYVPEGATREGFAGTYATQENFRLMRAALDESSRELGRYIRLTN 240
CAN93048         154 IVATGNIYDDAVQAKAAGFAGADIVAVIRATAQSLLDYVPEGPTTEGYGGTYATQENFRIIRRAADEATRDTGTYLAQTN 233
mpitm:STAUR_4748 156 IVATGNIYDDVDQARAAAQAGADVIAVIRSTAQSLLDYVPHGATTEGYGGTYATQENFRIMREALDEESKKLKRYIQLTN 235
Q2IHX5           163 IVATGNIHDDVEQARAAAQAGADVIAVIRSTAQSLLDYVPHGATTEGYGGTYATQENFRIMREALDDESRKLRRYVHLTN 242 Anaeromyxob...
1XRS_A           236 YCSGLCMPEIAAMGAIERLDVMLNDALYGILFRDINMQRTMIDQNFSRIINGFAGVIINTGEDNYLTTADAFEEAHTVLA 315 Acetoanaero...
WP_025357841     241 YASGLCMPEIAVLAGLERLDMMLNDSMYGILFRDINPIRTFVDQRFSRQVHARAGIIINTGEDNYLTTADAVEAAHTVTV 320 Kutzneria a...
Q67TH1           236 YASGLCMPEIAALGALERLDMMLSDSMYGILFRDINPKRTLIDQHFARMIQAEAGIIINTGEDNYLTTSDAYEAAHTVLA 315 Symbiobacte...
CCH88060         237 YASGLCMPEIAVLAGLERLDMMLNDAMYGILFRDINPRRTFVDQRFSRMVHARAGIIINTGEDNYLTTADAVDEAHTVTV 316
SIPI:L083_3927   238 YASGLCMPEMAVLAGLERLDMMLNDSMYGILFRDINPVRTFVDQRFSRQVHARAGIIINTGEDNYLTTADAVEAAHTVTV 317
WP_013019173     240 YASGLCMPEIAALAGMHRLDMMLNDCMYGILFRDINPIRTFVDQRLSRQIHARAGIIINTGEDNYLTTADAVEAAHTVTV 319 Stackebrand...
jgi:Kfla_3602    241 YASGLCMPEIATLAGLERLDMMLNDSMYGILFRDINPIRTFVDQRFSRQIHARAGIIINTGEDNYLTTADAVEAAHTVTV 320
CAN93048         234 YSSGLCMSEIAWMAAVERLDMLLNDAMYGILFRDINMQRTFIDQYFSRRIIARSGIVINTGEDNYLTTADAVEKAHTVLA 313
mpitm:STAUR_4748 236 YSSGLCMSEIAFCAATERLDMLLNDAMYGILFRDINMRRTFIDQYFSRRICALAGIIINTGEDNYITTADAYDAAHTVIA 315
Q2IHX5           243 YSSGLCMPEIAFSAAWERLDMLLNDAMYGILFRDINMKRTLCDQHFSRRICALAGILINTGEDNYITTADADEAAHTVVA 322 Anaeromyxob...
1XRS_A           316 SQFINEQFALLAGLPEEQMGLGHAFEMDPELKNGFLYELSQAQMAREIFPKAPLKYMPPTKFMTGNIFKGHIQDALFNMV 395 Acetoanaero...
WP_025357841     321 SQLLNERFAHEAGLPDELLGLGHAFEINPDLADSFRMELAHALLARELFPDAPLKWMPPTKHMTGDVFKGYLLDGFFNLV 400 Kutzneria a...
Q67TH1           316 SQFINEQFAHRSGMPDSQIGLGHAFEMDPSLEDGLLYEMADALLSRTCFPNAPLKYMPPTRHMTGDIFMGHVMDAMFNLT 395 Symbiobacte...
CCH88060         317 SQLLNETLAHEAGLADWQLGLGHAFEINPAVPESFRLELAHALLARGLFPDAPLKWMPPTKHMTGDVFGGYLLDGFFNLA 396
SIPI:L083_3927   318 SQLLNEYFAHEAGLADWQLGLGHAFEINPEVAESFRLELAHALLARELFPDAPLKWMPPTKHMTGDVFRGNLLDGFFNLA 397
WP_013019173     320 SQLLNEYFAHEAGLPDELLGLGHAFEINPDLKDSFRMELAHAMLARQLFPDAPLKWMPPTRHMTGDVFKGNLLDGFFNLA 399 Stackebrand...
jgi:Kfla_3602    321 SQLLNEYFAKEAGLQDWQLGLGHAFEITPEIPDSFRLELAHAMLARQLFPDAPLKWMPPTRHMTGDVFRGYLLDGFFNLA 400
CAN93048         314 SQFINEAFARRAGLREEQMGLGHAFEIDPWLEDSLLFELAQAQLVRQIFDRHPIKWMPPTKFKTGDIFHSHVHDAMFNLV 393
mpitm:STAUR_4748 316 SQFINECFARRAGLKDWQLGIGHSYEIDPYREDTLLLELSQAMLVRRCFPDAPLKYMPPTKHKETDIFFSHAYDVMADLV 395
Q2IHX5           323 SQFVNESFAHRAGLPDRLIGLGHSFEIDPEREDTIARELAQALLVRTLFPDAPIKYMPPTKHKQGDIFFSHAYDMMSDVV 402 Anaeromyxob...
1XRS_A           396 TIMTNQRIHLLGMLTEALHTPFMSDRALSIENAQYIFNNMESISEEIQFKEDGLIQKRAGFVLEKANELLEEIEQ--LGL 473 Acetoanaero...
WP_025357841     401 GALTGQGILLVGMMTEAVVTPFLSDRDLALANVRYVLNAAGNLHEDFRPAPDGFIVKRAHQVLGEAVDLLERICR--DGL 478 Kutzneria a...
Q67TH1           396 SVATGQQIHLVGILTEAIHTPYLHDRFLALENAKYVINYARHFTEEFQVRPGGRIERRASEVLERTLGLLEQIAE--RGL 473 Symbiobacte...
CCH88060         397 GALTGQGILLVGMMTEAVVTPWLSDRDLALRNVRYVLEAAGNLHEDFAPRPGGFIDRRAHTVLTEAVQLLERIADhpQGL 476
SIPI:L083_3927   398 GALTGQGILLVGMMTEAVVTPWLSDRDIALQNVRYVLSGAGNLHEDFVPAPGGFIQQRAHQVLDEAVALLDKIAS--ESL 475
WP_013019173     400 GAMTGQGILLVGMMTEAVVTPWLSDRDIALQNVRYVLNACGGLVEDFHPPADGFIANRARFVLDEAVDLLDKIVD--DGL 477 Stackebrand...
jgi:Kfla_3602    401 GAMTGQGILLVGMMTEAVVTPWISDRDLALQNVRYVLGAAGNLHEDFHPAPDGFIANRARQVLAESVELLDTIVD--DGL 478
CAN93048         394 GITTGQSIELLGMFSEAVHTPLLMDRYLSLKSARYIFTAARHLGDEIQWKPGGIVERRAREVLDKAHELLREVER--ETV 471
mpitm:STAUR_4748 396 AIWTRQGIQLLGMMTEAMHTPLLADRYVALKSAAYIHRAARGIDEEFTVREDGKIAHRAREVFGKALELLEECRN--EGM 473
Q2IHX5           403 GWVTGQGIQLLGMMTEAMHNPFLMDRYVALKGADYVYRAWRSMGAEITFRPGGMVESRARETLGKALALLEEVAR--DGL 480 Anaeromyxob...
1XRS_A           474 FDTLEKGIFGGVKRPKDGGKGLNGVVSKDENYYNPFVEL 512 Acetoanaerobium sticklandii
WP_025357841     479 LTAIAEGTFGLMKRPPDAGKGADGVVEKADGYVNPASEL 517 Kutzneria albida
Q67TH1           474 FQAIADGVFAGIRRPADGGKGLDGVLARGEGYLNPFYDL 512 Symbiobacterium thermophilum
CCH88060         477 IQAIADGTFGITKRSPDGGKGLDGVARLAADAYNPALEL 515
SIPI:L083_3927   476 LSAIADGTFGIMRRPADGGKGLDGVAAHAGDYFNPVTEa 514
WP_013019173     478 LNAIADGTFGIMKRPADAGRGLDGVEKHAEDYYNPATEL 516 Stackebrandtia nassauensis
jgi:Kfla_3602    479 LNAIGDGTFGLMKRPQDAGRGLDGVARRSAAYYNPAIEL 517
CAN93048         472 WDAIGRGAFGDVRRTRTGGKGYSGVVARHPEYLNPILDV 510
mpitm:STAUR_4748 474 VAAIGKGRFGDVKREETGGKGLDGVLEKSPDYFNPFLEL 512
Q2IHX5           481 PASIARARFGDVARAEDGGKGLSGVVTRGPAYFNPFLEI 519 Anaeromyxobacter dehalogenans 2CP-C
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