Conserved Protein Domain Family
Spt46
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pfam17734: Spt46 
Spermatogenesis-associated protein 46
This family is found in chordata. Functional characterization studies showed that the deletion of Spata46 in mice resulted in subfertility with abnormal sperm head shape and a failure of sperm-egg fusion. Spata46 has also been shown to localize to the nuclear membrane by a transmembrane region in the N-terminal.
Links
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Statistics
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PSSM-Id: 375300
Aligned: 8 rows
Threshold Bit Score: 398.489
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2YDE2         1 MENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPD-CILGDA 79  cattle
XP_010615269   1 MENFSLLSISGPRISSSARSTFPDILSSCSTSLPDIAKTVVPKEAANPAQSLPPQYQRSTLRHGVHSRVPFPD-CMPGDT 79 
XP_006103845   1 MESFSLLSISGPRVSSSALSTFPDLMSPRGPSLPDIAKTTFPTEAPSPAQAPLPQHPSSALRQG----VVLSPdCMLGDP 76 
XP_008262384   1 MENFSLLSISGPRISSSALSTFPNITSSRATSLPDIIRTAAPTEASSPAQTLPTQYSSSSFRHGVHNTVLSPD-CSLGDS 79 
XP_003893033   1 MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSITVRQGIQNTVLSPD-CSLGDT 79 
XP_003999602   1 MENFSLLSISGPRISSSALSAFPDIMSSHATSLPDIAKTALLTEASSPAQALSPQYFGSALRHGVQNTVLSPD-CLLGDP 79 
ELK16351       1 MESFSLLSISGPRISSSAPSAFPDIMSSRATSLPDIAKSALPSAAPSPAQARPPALASSVLRHRLRHALLSPD-CVLGDA 79 
XP_003434360   1 MENFSLLSISGPRISSSALSAFPDIMSSRATSLPDIAKSAPPPEASNAAQAPPARYHGSVLRHGVQNTLSSPD-CILGDS 79 

Q2YDE2        80 PNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRP 159 cattle
XP_010615269  80 PNGKQLRRNCIIYRPWFSPYSYFVCLDKESHLEACSLPEVEQDGCGGDSSLLEDVAESVCSSSSSPENTCPLEATRKARQ 159
XP_006103845  77 QNGEQPRRSCTIYRPWFSPYSYFVCVDKESPREAHGFPELPRDEGRGDSCLLEDTADSLCSSSSSPE----NPGPREAKA 152
XP_008262384  80 QNGEQLRRNCTIYRPWFSPYSYFVCTDKESHLEAYSFPEVQRDEGRGDNCLPEDMAESTCSSSSSPENTCPRDTTRKARP 159
XP_003893033  80 QHGEKLRRNCTIYRPWFSPYSYFVCADKESHLEAYDFPEVQQDEGKWDNCLSEDMAESICSSSSSAENTCPREATKKSRR 159
XP_003999602  80 QTRE-PRRGCTVYRPWFSPYSYFVCTDQESHLEAYSFPEVPRDKGRGDGCLPEDPAESICSSSSSQEDACPREAAKKFGH 158
ELK16351      80 QSGEQLRRNCTVYRPWFSPYSYFVCADVESRLEARSFSEALWDEGRGDGGLPEGLAESVCSSS-SPEDTCPREATQKPRH 158
XP_003434360  80 QKGEQLRRNCTIYRPWFSPYSYFVCTDQESHLEAYSFAEVQRDEGRGDSCSPEDLAESICSSSSSPENTCPREVSPKSRH 159

Q2YDE2       160 GPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYK 228 cattle
XP_010615269 160 SLDSIDYITSQDILVASKWYPAQQNGYKCAACCRMYPTLQSLKRHIRWGFKEGFSCRVYYRKLKVLWSR 228
XP_006103845 153 RHGDADHISSQDILRASRGLPAQQTGFKCAACCRMYPTLCSLKSHIKCGFREGFSCRVFYRKLKALWAR 221
XP_008262384 160 GVDSLDYITSQDILMACKWHPAQQNGYKCAACCRMYPTLHSLKSHIKVGFKEGFSCRVYYRKLKTLLGK 228
XP_003893033 160 GL---DSITSQDILMASRWHPAQQNGYKCAACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSK 225
XP_003999602 159 GLASTDGITSQDILKAARWHPAQQSGYKCAACCRMYPTLHSLKSHIKGGFREGFSCKVYYRKLKTLWGK 227
ELK16351     159 GPDAVDSITSQDILMASRWHPAQQSGYKCAACCRMYPSLRSLKSHIRGGFKEGFSCRVYYRRLKALWGK 227
XP_003434360 160 SLVPADHITSQDILTASKWHPAQQSGYKCVACCRMYPTLHSLKSHIKGGFREGFSCKVYYCKLKTLWGK 228
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