Conserved Protein Domain Family
LT_IagB-like
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cd13400: LT_IagB-like 
Escherichia coli invasion protein IagB and similar proteins
Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.
Links
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Statistics
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PSSM-Id: 381603
Aligned: 142 rows
Threshold Bit Score: 74.4876
Created: 6-Dec-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1: catalytic residue [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:residue involved in the cleavage of the beta-1,4-glycosidic bond in lytic transglycosylases
  • Citation:PMID 7548026
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #                                                                 
EZA15151      28 YNIPSSLLKAIAEKESRfnks--------------------------------avnvNNNGSKDYGIMQINDFHSKRLRE 75  Escherichia col...
WP_027180057  65 FDLPMELLHAVASHESHykpwavnisgrsyy-------------patrkraleiikkSGARSYDIGLMQVNSFWIEKFGL 131 Desulfovibrio b...
NP_214084     72 YGVPLNIVLAIIEKESSfnpk--------------------------------aynkNKDGTEDVGLMQINFQHNKRLMR 119 Aquifex aeolicu...
ACS79348      63 FSLHPEILNAIADHESGynpwalniegrsvy-------------pdsreealaiiekYKGKSYDVGLMQVNSYWIRKFDL 129 Desulfovibrio s...
WP_028949844  41 YNVPQGLLIAIAKVESGfrpwvininqngksvkv------inpksltealvyvrylhDNGYNYDVGIGQINVWNIKRLKL 114 Sulfurihydrogen...
WP_015419169  40 YGVNVKLLYAIAKVESDfnpyainvnangrsike------yypknkyqakivlnyllRHGYNFDVGIAQINIMNIKRWGL 113 Hydrogenobaculum
AAL59698      36 VGIDPVMLYAVALAESAshrglnmtspwpyairngsnatyakskteaeqllnqalqeSEKYQLDIGLMQINLHWHGHRVS 115 Vibrio cholerae
NP_220837    100 FNIPSNALYSIALKESGkkhstrkikvvwpwtvnvegkgyyfnskreainfvrieliKGRDSIDVGCMQINLRHHLEAFN 179 Rickettsia prow...
WP_022524272  15 YEVPIQVVAAVRQQESGsrgqav-----------------------------grigpNKNGTYDLGAMQINTWWLDPETN 65  Halomonas sp. A3H3
WP_005027707  29 YRIPKRLVLAIAKTESGldpwcvnvagkdyrp-----------gsrsgalaiirqarARGLSHDIGLMQINSWWLKHLNI 97  Bilophila wadsw...

Feature 1                                                                                
EZA15151      76 MGyte------emlISHPCLSVHYAAKLLNEFMLMy-GRGWEAVGAYNAGTSpkkkkerlkYAEDIYKRYLR 140 Escherichia coli O28ac:...
WP_027180057 132 DVa----------dAIIPDENLRLGAWILRYCFKRy-GNNWKAVGAYHTGSPanlpekaevYARQIYKKYLI 192 Desulfovibrio bastinii
NP_214084    120 EYgvns-----peeLYDPELNLELGVRILYENYKRy-GSWELAVKAYNGIRAdn-----wdYVKNVMERAKK 180 Aquifex aeolicus VF5
ACS79348     130 SPa----------eALEPEENLRLGAWILRYCLDRy-GYNWRAIGAYHTGSPknlpgraraYAVKVMKKYNA 190 Desulfovibrio salexigen...
WP_028949844 115 QPe----------qLLDPCNNIKVSAYILRENINKy-GLTWDAIWRYNGRKD---------YAYKVYNALIS 166 Sulfurihydrogenibium su...
WP_015419169 114 DPy----------aLLDPCYNLDVSAKLLRELVDRy-GLSWQAIWHYNGRPS---------YAYKVYHALIW 165 Hydrogenobaculum
AAL59698     116 SAa----------eLLDPITNLTVGSSILAEAIKSspNDLELGIGRYHSWNEera----rwYGQRVLSIYRN 173 Vibrio cholerae
NP_220837    180 SLd----------qAFDPHNNIRYGAEFLRSKYDQl-GSWHKAIAHYHSANHalg----vkYKQDVIKIASN 236 Rickettsia prowazekii s...
WP_022524272  66 RNhlqqwgiteqelLENECTNIAVGTWILYENITRy-GDWEAALAAYNAGSPespv--gqqYANQVLATLGD 134 Halomonas sp. A3H3
WP_005027707  98 SPe----------aALEPRNNATLGVWILAKEIQRh-GYNWKAVGAYHSPTParq----kmYAQVVSQKYRT 154 Bilophila wadsworthia

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